Schematics of the proposed participation of Pi4ka and PI3Ks in the FGF signaling cascade in the developing fin bud mesenchyme

Schematics of the proposed participation of Pi4ka and PI3Ks in the FGF signaling cascade in the developing fin bud mesenchyme. Pi4ka contributes to the generation of the PtdIns(4,5)P2 pool that is converted by the PI3Ks to PtdIns(3,4,5)P3 in the plasma membrane. Production of this latter lipid activates the Akt signaling cascade that regulates a host of downstream genes important for proliferation or protection of the cells from apoptosis. One of the most important genes regulated by this pathway is the MAPK phosphatase, MKP3 that is a key intermediate in driving pectoral fin development (). This phosphatase keeps a right balance between MAPK and the Akt pathways. The right panel shows the FGF signaling cascade in which the Fgf24-positive cell migration appears to be the first step showing impairment after Pi4ka depletion.

Publication

Crucial role of phosphatidylinositol 4-kinase IIIα in development of zebrafish pectoral fin is linked to phosphoinositide 3-kinase and FGF signaling. (2009) Hui Ma, et al. J Cell Sci. 2009 Dec 1;122(23):4303-4310. Figure: F6. All organisms Homo sapiens Danio rerio Drosophila melanogaster

Disease mentions