Nodal signaling pathway

The Nodal signaling pathway. After processing of the Nodal precursor by convertases, Nodal ligands signal through activin receptors and EGF-CFC coreceptors. Cerberus and Lefty act as extracellular inhibitors. MicroRNAs belonging to the miR-430 family target Nodal (zebrafish squint) and Lefty mRNAs for degradation and repression. Mir-15/16 represses the type II activin receptor. Rap2 is involved in the recycling of activin receptors whereas Dapper 2 targets activin receptor complexes for degradation in the lysosome. Pathway activation is mediated by phosphorylation of Smad2 and its association with Smad4 and transcription factors such as FoxH1, Mixer, and p53. Phospho-Smad2 is dephosphorylated by PPM1A and exported from the nucleus by RanBP3. Smad4 activity and stability is regulated by the ubiquitinase Ectodermin and the deubiquitinase FAM/Usp9x. See text for details.
Nodal signaling pathway
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Publication

Nodal Morphogens. (2009) Alexander F. Schier. Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a003459. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates Nodal NODAL ncbigene_symbol NODAL 4838
Homo sapiens Primates MIR-15/16 MIR16 ncbigene_synonym GDE1 51573
Homo sapiens Primates Activin ACTIVIN famplex_relations INHBA 3624
Homo sapiens Primates Activin ACTIVIN famplex_relations INHBB 3625
Homo sapiens Primates Dapper DAPPER ncbigene_synonym DACT1 51339
Homo sapiens Primates Dapper2 DAPPER2 ncbigene_synonym DACT2 168002
Homo sapiens Primates Rap2 RAP2 ncbigene_synonym RAP2A 5911
Homo sapiens Primates Smad2 SMAD2 ncbigene_symbol SMAD2 4087
Homo sapiens Primates Smad4 SMAD4 ncbigene_symbol SMAD4 4089
Homo sapiens Primates PPM1A PPM1A ncbigene_symbol PPM1A 5494
Homo sapiens Primates FAM FAM ncbigene_synonym USP9X 8239
Homo sapiens Primates RanBP3 RANBP3 ncbigene_symbol RANBP3 8498
Homo sapiens Primates FoxH1 FOXH1 ncbigene_symbol FOXH1 8928
Homo sapiens Primates p53 P53 ncbigene_synonym TP53 7157
Homo sapiens Primates p53 P53 famplex_relations TP63 8626
Homo sapiens Primates p53 P53 famplex_relations TP73 7161
Danio rerio Vertebrates Dapper2 DAPPER2 ncbigene_synonym dact2 337795
Danio rerio Vertebrates Smad2 SMAD2 ncbigene_symbol smad2 30639
Danio rerio Vertebrates Smad4 SMAD4 ncbigene_synonym smad4a 559111
Danio rerio Vertebrates Smad4 SMAD4 ncbigene_synonym smad4b 794669
Danio rerio Vertebrates PPM1A PPM1A ncbigene_synonym ppm1bb 100003481
Danio rerio Vertebrates RanBP3 RANBP3 ncbigene_synonym ranbp3a 394115
Danio rerio Vertebrates FoxH1 FOXH1 ncbigene_symbol foxh1 57930
Danio rerio Vertebrates p53 P53 ncbigene_synonym tp53 30590

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID