The PI3k/Akt signaling pathway depicting the possible sites of action by the PI3k inhibitors LY294002 and wortmannin and the Akt inhibitors Akt-VIII, Akt-V, and Akt-IV

Schematic of the PI3k/Akt signaling pathway depicting the possible sites of action by the PI3k inhibitors LY294002 and wortmannin and the Akt inhibitors Akt-VIII, Akt-V, and Akt-IV. PIP2, phosphatidylinositol 4,5-biphosphate; PIP3, phosphatidylinositol 3,4,5-triphosphate.
The PI3k/Akt signaling pathway depicting the possible sites of action by the PI3k inhibitors LY294002 and wortmannin and the Akt inhibitors Akt-VIII, Akt-V, and Akt-IV
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Publication

Akt Inhibitor Akt-IV Blocks Virus Replication through an Akt-Independent Mechanism . (2009) Ewan F. Dunn, et al. J Virol. 2009 Nov;83(22):11665-11672. Figure: F6.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates PDK1 PDK1 ncbigene_symbol PDK1 5163
Homo sapiens Primates PDK1 PDK1 ncbigene_synonym PDPK1 5170
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates PI3k PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3k PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3k PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3k PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3k PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3k PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3k PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3k PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3k PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3k PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates -C2 C2 ncbigene_symbol C2 717
Drosophila melanogaster Invertebrates PDK1 PDK1 ncbigene_symbol Pdk1 38017
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates PI3k PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3k PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3k PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3k PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396
Arabidopsis thaliana Plants and Fungi PIP3 PIP3 ncbigene_symbol PIP3 829662
Arabidopsis thaliana Plants and Fungi PIP2 PIP2 ncbigene_synonym PIP2A 824510
Arabidopsis thaliana Plants and Fungi PDK1 PDK1 ncbigene_symbol PDK1 830330
Arabidopsis thaliana Plants and Fungi PI3k PI3K ncbigene_synonym VPS34 842344
Arabidopsis thaliana Plants and Fungi -C2 C2 ncbigene_symbol C2 821323

Chemical mentions

Word Match MeSH Name ChEBI
LY294002 NA mesh:C085911

Disease mentions

Word Match MeSH Name DOID