Selective pathway utilization of analogs is ensured by the nonpermissivity of enzymes at critical junctures

Selective pathway utilization of analogs is ensured by the nonpermissivity of enzymes at critical junctures. The interconnectedness of glycosylation pathways linking hexosamines (and fucose) used in metabolic glycoengineering is diagrammed indicating enzymes that are restrictive to analog utilization (the complete names of the enzymes are provided in Table S1 in the Supplementary Data available online). The restrictive nature of key enzymes results in the partitioning of GalNAc, GlcNAc, ManNAc, and fucose analogs into selectively targeted classes of mature glycans (inset, indicated with the starred symbols).
Selective pathway utilization of analogs is ensured by the nonpermissivity of enzymes at critical junctures
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Publication

Metabolic glycoengineering: Sialic acid and beyond. (2009) Jian Du, et al. Glycobiology. 2009 Dec;19(12):1382-1401. Figure: F6.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Danio rerio Vertebrates GALK2 GALK2 ncbigene_symbol galk2 792268
Danio rerio Vertebrates RENBP RENBP ncbigene_symbol renbp 791728
Danio rerio Vertebrates UAP1 UAP1 ncbigene_symbol uap1 322513
Danio rerio Vertebrates GNE GNE ncbigene_symbol gne 393857
Danio rerio Vertebrates GALE GALE ncbigene_symbol gale 678540
Danio rerio Vertebrates OGT OGT ncbigene_synonym ogt.1 337685
Danio rerio Vertebrates DPAGT1 DPAGT1 ncbigene_symbol dpagt1 566539
Danio rerio Vertebrates FUK FUK ncbigene_symbol fuk 100150934
Danio rerio Vertebrates FPGT FPGT ncbigene_symbol fpgt 553792
Homo sapiens Primates OGlcNAC OGLCNAC ncbigene_synonym OGT 8473
Homo sapiens Primates GALK2 GALK2 ncbigene_symbol GALK2 2585
Homo sapiens Primates RENBP RENBP ncbigene_symbol RENBP 5973
Homo sapiens Primates UAP1 UAP1 ncbigene_symbol UAP1 6675
Homo sapiens Primates GNE GNE ncbigene_symbol GNE 10020
Homo sapiens Primates GALE GALE ncbigene_symbol GALE 2582
Homo sapiens Primates OGT OGT famplex_relations EOGT 285203
Homo sapiens Primates OGT OGT famplex_relations POMGNT1 55624
Homo sapiens Primates OGT OGT famplex_relations POMGNT2 84892
Homo sapiens Primates GALNT GALNT famplex_relations GALNTL5 168391
Homo sapiens Primates GALNT GALNT famplex_relations GALNTL6 442117
Homo sapiens Primates GALNT GALNT famplex_relations GALNT1 2589
Homo sapiens Primates GALNT GALNT famplex_relations GALNT2 2590
Homo sapiens Primates GALNT GALNT famplex_relations GALNT3 2591
Homo sapiens Primates GALNT GALNT famplex_relations GALNT4 8693
Homo sapiens Primates GALNT GALNT famplex_relations GALNT5 11227
Homo sapiens Primates GALNT GALNT famplex_relations GALNT6 11226
Homo sapiens Primates GALNT GALNT famplex_relations GALNT7 51809
Homo sapiens Primates GALNT GALNT famplex_relations GALNT8 26290
Homo sapiens Primates GALNT GALNT famplex_relations GALNT9 50614
Homo sapiens Primates GALNT GALNT famplex_relations GALNT10 55568
Homo sapiens Primates GALNT GALNT famplex_relations GALNT11 63917
Homo sapiens Primates GALNT GALNT famplex_relations GALNT12 79695
Homo sapiens Primates GALNT GALNT famplex_relations GALNT13 114805
Homo sapiens Primates GALNT GALNT famplex_relations GALNT14 79623
Homo sapiens Primates GALNT GALNT famplex_relations GALNT15 117248
Homo sapiens Primates GALNT GALNT famplex_relations GALNT16 57452
Homo sapiens Primates GALNT GALNT famplex_relations GALNT18 374378
Homo sapiens Primates GALNT GALNT famplex_relations GALNT17 64409
Homo sapiens Primates DPAGT1 DPAGT1 ncbigene_symbol DPAGT1 1798
Homo sapiens Primates FUK FUK ncbigene_synonym FCSK 197258
Homo sapiens Primates FPGT FPGT ncbigene_symbol FPGT 8790

Chemical mentions

Word Match MeSH Name ChEBI
CMP-Neu5Ac NA mesh:C561601
O Galactose Galactose mesh:D005690 galactose chebi:28260
O Mannose Mannose mesh:D008358 D-mannopyranose chebi:4208
Sialic acid sialic acid mesh:D012794 Sialic Acids chebi:26667
UDP Uridine Diphosphate mesh:D014530 UDP chebi:17659

Disease mentions

Word Match MeSH Name DOID