Rev-erbA/PGC-1A pathway regulating heme homeostasis

The Rev-erbα/PGC-1α pathway regulating heme homeostasis. Heme promotes Rev-erbα repression of PGC-1α, thereby reducing ALAS1 gene expression and heme biosynthesis. Conversely, low heme levels reduce Rev-erbα repression, enhancing PGC-1α stimulation of heme synthesis via transcriptional activation of the rate-limiting enzyme ALAS1.
Rev-erbA/PGC-1A pathway regulating heme homeostasis
Download JPG
View figure at PMC Read paper at PMC Open at NDEx
PMC
NDEx

Publication

Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbα. (2009) Nan Wu, et al. Genes Dev. 2009 Sep 15;23(18):2201-2209. Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates ALAS1 ALAS1 ncbigene_symbol ALAS1 211
Homo sapiens Primates NRF1 NRF1 ncbigene_symbol NRF1 4899
Homo sapiens Primates NRF1 NRF1 ncbigene_synonym NFE2L1 4779
Homo sapiens Primates NCOR NCOR ncbigene_synonym NCOR1 9611
Homo sapiens Primates NCOR NCOR famplex_relations NCOR2 9612
Homo sapiens Primates RORA RORA ncbigene_symbol RORA 6095
Homo sapiens Primates clock: CLOCK ncbigene_symbol CLOCK 9575
Homo sapiens Primates Bmal1 BMAL1 ncbigene_symbol BMAL1 406
Homo sapiens Primates PGC-1 PGC1 ncbigene_synonym PPARGC1A 10891
Homo sapiens Primates PEPCK,G6Pase PEPCK ncbigene_synonym PCK2 5106
Homo sapiens Primates PEPCK,G6Pase G6PASE ncbigene_synonym G6PC1 2538
Homo sapiens Primates PEPCK,G6Pase G6PASE famplex_relations G6PC2 57818
Homo sapiens Primates PEPCK,G6Pase G6PASE famplex_relations G6PC3 92579
Homo sapiens Primates Rev-erba REVERBA ncbigene_synonym NR1D1 9572
Homo sapiens Primates CREB CREB ncbigene_synonym CREB1 1385
Homo sapiens Primates CREB CREB famplex_relations CREB3 10488
Homo sapiens Primates CREB CREB famplex_relations CREB5 9586
Homo sapiens Primates CREB CREB famplex_relations CREB3L1 90993
Homo sapiens Primates CREB CREB famplex_relations CREB3L2 64764
Homo sapiens Primates CREB CREB famplex_relations CREB3L3 84699
Homo sapiens Primates CREB CREB famplex_relations CREB3L4 148327
Homo sapiens Primates CREB CREB famplex_relations CREM 1390
Homo sapiens Primates CREB CREB famplex_relations ATF1 466
Homo sapiens Primates CREB CREB famplex_relations ATF2 1386
Mus musculus Rodents ALAS1 ALAS1 ncbigene_symbol Alas1 11655
Mus musculus Rodents NRF1 NRF1 ncbigene_symbol Nrf1 18181
Mus musculus Rodents NRF1 NRF1 ncbigene_synonym Nfe2l1 18023
Mus musculus Rodents NCOR NCOR ncbigene_synonym Ncor1 20185
Mus musculus Rodents NCOR NCOR ncbigene_synonym Ncor2 20602
Mus musculus Rodents RORA RORA ncbigene_symbol Rora 19883
Mus musculus Rodents clock: CLOCK ncbigene_symbol Clock 12753
Mus musculus Rodents Bmal1 BMAL1 ncbigene_symbol Bmal1 11865
Mus musculus Rodents PGC-1 PGC-1 ncbigene_synonym Ppargc1a 19017
Mus musculus Rodents PEPCK,G6Pase PEPCK ncbigene_synonym Pck1 18534
Mus musculus Rodents PEPCK,G6Pase G6PASE ncbigene_synonym G6pc1 14377
Mus musculus Rodents CREB CREB ncbigene_synonym Creb1 12912

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID