NFKB signal transduction

NF-κB signal transduction. Extracellular stimulation of microbial ligands such as lipolysaccharide trigger the canonical NF-κB pathway that leads to septic shock. Shortly after stimulation, a series of ubiquitination events occur that activate TAK1 and IKK complexes. This ultimately promotes IκBα phosphorylation and its subsequent proteolysis, thereby allowing the translocation of NF-κB into the nucleus where it promotes the transcription of its target genes. IKK = IκB kinase; JNK = c-Jun N-terminal kinase; MKK6 = Mitogen-activated protein kinase kinase 6; MyD88 = Myeloid differentiation primary response gene (88); NF = nuclear factor; TRAF = TNF-receptor-associated factor.

Publication

Targeting the ubiquitin proteasome pathway for the treatment of septic shock in patients. (2009) Jan Brun, et al. Crit Care. 2009;13(4):311-311. Figure: F2. All organisms Homo sapiens Mus musculus Drosophila melanogaster Danio rerio

Disease mentions