Sialic acid synthesis pathway
Sialic acid synthesis pathway. The biosynthesis of sialic acid (Neu5Ac) occurs in the cytosol, where glucose undergoes several modifications to become UDP-GlcNAc. The UDP-GlcNAC 2-epimerase activity of GNE/MNK then epimerises UDP-GlcNAc into ManNAc, after which its ManNAc kinase activity further converts this to ManNAc-6-P, which is then converted in several steps to the downstream product CMP-sialic acid. CMP-sialic acid is utilized by the Golgi complex to sialylate glycoconjugates. CMP-sialic acid can feedback-inhibit the UDP-GlcNAc 2-epimerase enzymatic activity in its allosteric site. For more details, see text.
Publication
Hereditary Inclusion Body Myopathy: A Decade of Progress. () Marjan Huizing, et al. Biochim Biophys Acta. ;1792(9):881-887. Figure: F2.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | ATP | ATP | ncbigene_synonym | ATPsynbeta | 43829 |
| Drosophila melanogaster | Invertebrates | ATP | ATP | ncbigene_synonym | Atpalpha | 48971 |
| Drosophila melanogaster | Invertebrates | PEP | PEP | ncbigene_symbol | Pep | 45961 |
| Drosophila melanogaster | Invertebrates | PEP | PEP | ncbigene_synonym | bgcn | 47873 |
| Drosophila melanogaster | Invertebrates | CMP | CMP | ncbigene_symbol | cmp | 248126 |
| Drosophila melanogaster | Invertebrates | CTP | CTP | ncbigene_symbol | ctp | 31405 |
| Homo sapiens | Primates | ATP | ATP | ncbigene_synonym | ATP8A2 | 51761 |
| Homo sapiens | Primates | PEP | PEP | ncbigene_synonym | PAEP | 5047 |
| Homo sapiens | Primates | PEP | PEP | ncbigene_synonym | PREP | 5550 |
| Homo sapiens | Primates | PEP | PEP | ncbigene_synonym | PTPN22 | 26191 |
| Homo sapiens | Primates | CMP | CMP | ncbigene_synonym | MATN1 | 4146 |
| Homo sapiens | Primates | CTP | CTP | ncbigene_synonym | SLC25A1 | 6576 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| ManNAc-6-P | NA | mesh:C430285 | ||
| CMP | Cytidine Monophosphate | mesh:D003568 | cytidine 5'-monophosphate | chebi:17361 |
| CMP-sialic acid | Cytidine Monophosphate N-Acetylneuraminic Acid | mesh:D003569 | CMP-N-acetyl-beta-neuraminic acid | chebi:16556 |
| Glucose | Glucose | mesh:D005947 | D-glucopyranose | chebi:4167 |
| sialic acid | sialic acid | mesh:D012794 | Sialic Acids | chebi:26667 |
| UDP | Uridine Diphosphate | mesh:D014530 | UDP | chebi:17659 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
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