Monoclonal antibodies in the treatment of pancreatic cancer

Death receptor 5 is a member of the TNF-receptor superfamily. When the TRAIL (or TRA-8) binds to receptor, the receptor forms a homotrimer, which subsequently induces the death-inducing signaling complex formation. DISC includes FADD, caspase 8 and cIAP or FLIP. Apoptosis is induced by the activation of caspase 8/caspase 3 as well as activation of the intrinsic mitochondrial pathway.FADD: Fas-associated death domain protein; TRAIL: TNF-related apoptosis-inducing ligand.
Monoclonal antibodies in the treatment of pancreatic cancer
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Publication

Monoclonal antibodies in the treatment of pancreatic cancer. () Zhi-Qiang Huang, et al. Immunotherapy. ;1(2):223-239. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates TRAIL TRAIL ncbigene_synonym TNFSF10 8743
Homo sapiens Primates FADD FADD ncbigene_symbol FADD 8772
Homo sapiens Primates Caspase CASPASE famplex_relations CASP1 834
Homo sapiens Primates Caspase CASPASE famplex_relations CASP2 835
Homo sapiens Primates Caspase CASPASE famplex_relations CASP4 837
Homo sapiens Primates Caspase CASPASE famplex_relations CASP5 838
Homo sapiens Primates Caspase CASPASE famplex_relations CASP6 839
Homo sapiens Primates Caspase CASPASE famplex_relations CASP8 841
Homo sapiens Primates Caspase CASPASE famplex_relations CASP9 842
Homo sapiens Primates Caspase CASPASE famplex_relations CASP10 843
Homo sapiens Primates Caspase CASPASE famplex_relations CASP12 100506742
Homo sapiens Primates Caspase CASPASE famplex_relations CASP14 23581
Homo sapiens Primates Caspase CASPASE famplex_relations CASP3 836
Homo sapiens Primates Caspase CASPASE famplex_relations CASP7 840
Homo sapiens Primates Bid BID ncbigene_symbol BID 637
Homo sapiens Primates Bax,Bak BAK ncbigene_synonym BAK1 578
Homo sapiens Primates Bax,Bak BAX ncbigene_symbol BAX 581

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID