Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD

Group I mGluRs activate eEF2K via calcium-calmodulin (CaM). eEF2K phosphorylates eEF2, which inhibits elongation generally but increases Arc/Arg3.1 translation. Arc/Arg3.1 forms a complex with endophilin2/3 (Endo) and dynamin (Dyn) and induces the internalization of AMPAR (). FMRP inhibits the translation of Arc/Arg3.1 at the basal state. Arc/Arg3.1 induction alone is not sufficient for mGluR-LTD, indicating that mGluR activates another pathway that is required to internalize AMPAR (). In Fmr1 KO mice, the synthesis of Arc/Arg3.1 protein is constitutively derepressed, and de novo synthesis of Arc/Arg3.1 is not required for mGluR-LTD.
Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD
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Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD. (2008) Sungjin Park, et al. Neuron. 2008 Jul 10;59(1):70-83. Figure: F8.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates mGluR MGLUR ncbigene_symbol mGluR 43838
Drosophila melanogaster Invertebrates Arc ARC ncbigene_synonym Arc1 36595
Drosophila melanogaster Invertebrates Arc ARC ncbigene_synonym Dark 36914
Drosophila melanogaster Invertebrates Arc ARC ncbigene_synonym NA 43852
Drosophila melanogaster Invertebrates Endo ENDO ncbigene_synonym EndoA 42265
Drosophila melanogaster Invertebrates Dyn DYN ncbigene_synonym shi 45928
Drosophila melanogaster Invertebrates EEF2 EEF2 ncbigene_symbol eEF2 35422
Drosophila melanogaster Invertebrates EEF2 EEF2 ncbigene_synonym CG4849 43358
Drosophila melanogaster Invertebrates FMRP FMRP ncbigene_synonym Fmr1 37528
Drosophila melanogaster Invertebrates de DE ncbigene_symbol de 248301
Mus musculus Rodents mGluR GRM ncbigene_synonym Tpst2 22022
Mus musculus Rodents EEF2K EEF2K ncbigene_symbol Eef2k 13631
Mus musculus Rodents Arc ARC ncbigene_symbol Arc 11838
Mus musculus Rodents Arc ARC ncbigene_synonym Nol3 78688
Mus musculus Rodents Endo ENDO ncbigene_synonym Eng 13805
Mus musculus Rodents Dyn DYN ncbigene_synonym Pdyn 18610
Mus musculus Rodents Dyn DYN ncbigene_synonym Sptbn4 80297
Mus musculus Rodents EEF2 EEF2 ncbigene_symbol Eef2 13629
Mus musculus Rodents FMRP FMRP ncbigene_synonym Fmr1 14265
Homo sapiens Primates mGluR GRM famplex_relations GRM1 2911
Homo sapiens Primates mGluR GRM famplex_relations GRM2 2912
Homo sapiens Primates mGluR GRM famplex_relations GRM3 2913
Homo sapiens Primates mGluR GRM famplex_relations GRM4 2914
Homo sapiens Primates mGluR GRM famplex_relations GRM5 2915
Homo sapiens Primates mGluR GRM famplex_relations GRM6 2916
Homo sapiens Primates mGluR GRM famplex_relations GRM7 2917
Homo sapiens Primates mGluR GRM famplex_relations GRM8 2918
Homo sapiens Primates EEF2K EEF2K ncbigene_symbol EEF2K 29904
Homo sapiens Primates Arc ARC ncbigene_symbol ARC 23237
Homo sapiens Primates Arc ARC ncbigene_synonym NOL3 8996
Homo sapiens Primates Endo ENDO ncbigene_synonym MANEA 79694
Homo sapiens Primates EEF2 EEF2 ncbigene_symbol EEF2 1938
Homo sapiens Primates FMRP FMRP ncbigene_synonym FMR1 2332
Rattus norvegicus Rodents mGluR MGLUR ncbigene_synonym Grm8 60590
Rattus norvegicus Rodents EEF2K EEF2K ncbigene_symbol Eef2k 25435
Rattus norvegicus Rodents Arc ARC ncbigene_symbol Arc 54323
Rattus norvegicus Rodents Arc ARC ncbigene_synonym Nol3 85383
Rattus norvegicus Rodents EEF2 EEF2 ncbigene_symbol Eef2 29565
Rattus norvegicus Rodents FMRP FMRP ncbigene_synonym Fmr1 24948
Oryctolagus cuniculus Mammals EEF2K EEF2K ncbigene_symbol EEF2K 100347896
Oryctolagus cuniculus Mammals Arc ARC ncbigene_symbol ARC 127486797
Oryctolagus cuniculus Mammals EEF2 EEF2 ncbigene_symbol EEF2 127485698
Equus caballus Mammals EEF2K EEF2K ncbigene_symbol EEF2K 100058387
Equus caballus Mammals Arc ARC ncbigene_symbol ARC 100146865
Equus caballus Mammals EEF2 EEF2 ncbigene_symbol EEF2 100061437

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID