Schematic showing the pathway for synthesis and mode of action of prostacyclin (PGI2)

Schematic showing the pathway for synthesis and mode of action of prostacyclin (PGI2). Various agents used in this study are also shown in the figure. COX, cyclo-oxygenase; AA, arachidonic acid; PGH2, prostaglandin H2; PGIS, prostacyclin synthase; IP, prostacyclin receptor; PDE3, phosphodiesterase 3.
Schematic showing the pathway for synthesis and mode of action of prostacyclin (PGI2)
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Publication

Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn. () Satyan Lakshminrusimha, et al. Pediatr Crit Care Med. ;10(1):106-112. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates COX COX ncbigene_synonym COX8A 1351
Homo sapiens Primates COX COX ncbigene_synonym CPOX 1371
Homo sapiens Primates COX COX ncbigene_synonym COX5A 9377
Homo sapiens Primates COX COX famplex_relations COX5B 1329
Homo sapiens Primates COX COX famplex_relations COX6C 1345
Homo sapiens Primates COX COX famplex_relations COX7C 1350
Homo sapiens Primates COX COX famplex_relations NA NaN
Homo sapiens Primates COX COX famplex_relations COX4I1 1327
Homo sapiens Primates COX COX famplex_relations COX4I2 84701
Homo sapiens Primates COX COX famplex_relations COX6A1 1337
Homo sapiens Primates COX COX famplex_relations COX6A2 1339
Homo sapiens Primates COX COX famplex_relations COX6B1 1340
Homo sapiens Primates COX COX famplex_relations COX6B2 125965
Homo sapiens Primates COX COX famplex_relations COX7A1 1346
Homo sapiens Primates COX COX famplex_relations COX7A2 1347
Homo sapiens Primates COX COX famplex_relations COX7B 1349
Homo sapiens Primates COX COX famplex_relations COX7B2 170712
Homo sapiens Primates COX COX famplex_relations COX8C 341947
Homo sapiens Primates PGIS PGIS ncbigene_synonym PTGIS 5740
Homo sapiens Primates ATP ATP ncbigene_synonym ATP8A2 51761
Homo sapiens Primates PDE3 PDE3 famplex_relations PDE3A 5139
Homo sapiens Primates PDE3 PDE3 famplex_relations PDE3B 5140
Homo sapiens Primates COX COX ncbigene_synonym COX8A 1351
Homo sapiens Primates COX COX ncbigene_synonym CPOX 1371
Homo sapiens Primates COX COX ncbigene_synonym COX5A 9377
Homo sapiens Primates COX COX famplex_relations COX5B 1329
Homo sapiens Primates COX COX famplex_relations COX6C 1345
Homo sapiens Primates COX COX famplex_relations COX7C 1350
Homo sapiens Primates COX COX famplex_relations NA NaN
Homo sapiens Primates COX COX famplex_relations COX4I1 1327
Homo sapiens Primates COX COX famplex_relations COX4I2 84701
Homo sapiens Primates COX COX famplex_relations COX6A1 1337
Homo sapiens Primates COX COX famplex_relations COX6A2 1339
Homo sapiens Primates COX COX famplex_relations COX6B1 1340
Homo sapiens Primates COX COX famplex_relations COX6B2 125965
Homo sapiens Primates COX COX famplex_relations COX7A1 1346
Homo sapiens Primates COX COX famplex_relations COX7A2 1347
Homo sapiens Primates COX COX famplex_relations COX7B 1349
Homo sapiens Primates COX COX famplex_relations COX7B2 170712
Homo sapiens Primates COX COX famplex_relations COX8C 341947
Homo sapiens Primates PGIS PGIS ncbigene_synonym PTGIS 5740
Homo sapiens Primates ATP ATP ncbigene_synonym ATP8A2 51761
Homo sapiens Primates PDE3 PDE3 famplex_relations PDE3A 5139
Homo sapiens Primates PDE3 PDE3 famplex_relations PDE3B 5140

Chemical mentions

Word Match MeSH Name ChEBI
Forskolin Colforsin mesh:D005576 forskolin chebi:42471
Indomethacin Indomethacin mesh:D007213 indometacin chebi:49662
Milrinone Milrinone mesh:D020105 milrinone chebi:50693

Disease mentions

Word Match MeSH Name DOID