TGFB signaling pathway

TGFβsignaling pathway in male Schistosoma mansoni showing signaling from the female to the male that contributes to parasite pairing (based on experimental data). The cartoon depicts surface-exposed tegument of the gynecophoric canal. SmTGFβtype II receptor (RII) binds a parasite or a host TGFβ ligand (SmInAct, hTGFβ1). The ligand/RII complex triggers the interaction with a type I receptor (RIA; SmTβRI), phosphorylates and activates it. The activated type I receptor relays the signal down to a R-Smad (RIA to SmSmad2), where the SmSmad2 is activated via phosphorylation. The activated SmSmad2 interacts with the co-Smad (SmSmad4) in the subtegument. The SmSmad complex translocates to the nucleus of the sub-tegumental cell, binds nuclear partners and the assembled transcription complex binds to the Smad binding element in the promoter of the target gene (SmGCP) and regulates target gene transcription. The SmGCP transcript is translated and the protein transported to the surface of the gynecophoric canal where it facilitates worm pairing. See text and [, , ] for further details.(modified from []).

Publication

Signal Transduction Regulates Schistosome Reproductive Biology. () Philip T. LoVerde, et al. Curr Opin Microbiol. ;12(4):422-428. Figure: F2. All organisms Homo sapiens Drosophila melanogaster

Disease mentions