Mechanism of action of sorafenib
Mechanism of action of sorafenib. Sorafenib exerts a dual anticancer effect on the tumor and tumor vasculature by inhibiting Raf kinases including Raf-1 as well as the receptor tyrosine kinases vascular endothelial growth factor receptor 2 (VEGFR2), VEGFR3, platelet-derived growth factor receptor (PDGFR), etc. Reproduced with permission from . Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway. Semin Oncol, 33:392–406. Copyright © 2006 Elsevier.Abbreviation: Sf, sorafenib.
Publication
Sorafenib for the treatment of unresectable hepatocellular carcinoma. (2008) Junji Furuse. Biologics. 2008 Dec;2(4):779-788. Figure: F2.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | PDGF-B | PDGFB | ncbigene_symbol | PDGFB | 5155 |
| Homo sapiens | Primates | VEGF | VEGF | ncbigene_synonym | VEGFA | 7422 |
| Homo sapiens | Primates | VEGF | VEGF | famplex_relations | VEGFB | 7423 |
| Homo sapiens | Primates | VEGF | VEGF | famplex_relations | VEGFC | 7424 |
| Homo sapiens | Primates | VEGF | VEGF | famplex_relations | VEGFD | 2277 |
| Homo sapiens | Primates | VEGF | VEGF | famplex_relations | PGF | 5228 |
| Homo sapiens | Primates | TGFa | TGFA | ncbigene_symbol | TGFA | 7039 |
| Homo sapiens | Primates | PDGFR-B | PDGFRB | ncbigene_symbol | PDGFRB | 5159 |
| Homo sapiens | Primates | VEGFR-2 | VEGFR2 | ncbigene_synonym | KDR | 3791 |
| Homo sapiens | Primates | EGFR | EGFR | ncbigene_symbol | EGFR | 1956 |
| Homo sapiens | Primates | Sf | SF | ncbigene_symbol | SF | 6420 |
| Homo sapiens | Primates | Ras | RAS | famplex_relations | KRAS | 3845 |
| Homo sapiens | Primates | Ras | RAS | famplex_relations | HRAS | 3265 |
| Homo sapiens | Primates | Ras | RAS | famplex_relations | NRAS | 4893 |
| Homo sapiens | Primates | Raf-1 | RAF-1 | ncbigene_synonym | RAF1 | 5894 |
| Homo sapiens | Primates | VHL | VHL | ncbigene_symbol | VHL | 7428 |
| Homo sapiens | Primates | MEK | MEK | ncbigene_synonym | MAP2K7 | 5609 |
| Homo sapiens | Primates | MEK | MEK | famplex_relations | MAP2K1 | 5604 |
| Homo sapiens | Primates | MEK | MEK | famplex_relations | MAP2K2 | 5605 |
| Homo sapiens | Primates | HIF- | HIF | famplex_relations | HIF1A | 3091 |
| Homo sapiens | Primates | HIF- | HIF | famplex_relations | EPAS1 | 2034 |
| Homo sapiens | Primates | HIF- | HIF | famplex_relations | HIF3A | 64344 |
| Homo sapiens | Primates | HIF- | HIF | famplex_relations | ARNT | 405 |
| Homo sapiens | Primates | HIF- | HIF | famplex_relations | ARNT2 | 9915 |
| Homo sapiens | Primates | HIF- | HIF | famplex_relations | BMAL1 | 406 |
| Homo sapiens | Primates | IF2 | IF2 | ncbigene_synonym | EIF5B | 9669 |
| Homo sapiens | Primates | ERK | ERK | ncbigene_synonym | EPHB2 | 2048 |
| Homo sapiens | Primates | ERK | ERK | ncbigene_synonym | MAPK1 | 5594 |
| Homo sapiens | Primates | ERK | ERK | famplex_relations | MAPK3 | 5595 |
| Homo sapiens | Primates | PDGF | PDGF | famplex_relations | PDGFA | 5154 |
| Homo sapiens | Primates | PDGF | PDGF | famplex_relations | PDGFC | 56034 |
| Homo sapiens | Primates | PDGF | PDGF | famplex_relations | PDGFD | 80310 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| Cancer | NA |