Simplified scheme of the VEGF/VEGFR pathway

A simplified scheme of the VEGF/VEGFR pathway. The development of blood vessels is regulated by production of several growth factors, such as TGF-α and VEGF, that are secreted by cancer cells to stimulate normal endothelial cell growth through paracrine mechanisms. VEGF binds to two different receptors: VGFR-1 (flt-1) and VEGFR-2 (flk/KDR). VEFG is a potent and specific mitogen for endothelial cells, activates angiogenesis and enhances vascular permeability.Abbreviations: VEGF, vascular endothelial growth factor; TGF-α, transforming growth factor-α; VEGFR-1, vascular endothelial growth factor receptor-1; VEGFR-2, vascular endothelial growth factor receptor-2.
Simplified scheme of the VEGF/VEGFR pathway
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Publication

First line targeted therapies in breast cancer: focus on bevacizumab. (2007) Amalia Milano, et al. Biologics. 2007 Mar;1(1):3-10. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates VEGF VEGF ncbigene_synonym VEGFA 7422
Homo sapiens Primates VEGF VEGF famplex_relations VEGFB 7423
Homo sapiens Primates VEGF VEGF famplex_relations VEGFC 7424
Homo sapiens Primates VEGF VEGF famplex_relations VEGFD 2277
Homo sapiens Primates VEGF VEGF famplex_relations PGF 5228
Homo sapiens Primates VEGFR-2(KIk/KDR) KDR ncbigene_symbol KDR 3791
Homo sapiens Primates VEGFR-1 VEGFR-1 ncbigene_synonym FLT1 2321
Homo sapiens Primates (flt-1) FIT1 ncbigene_synonym IL1RL1 9173
Homo sapiens Primates (flt-1) FIT1 ncbigene_synonym FITM1 161247
Homo sapiens Primates EGFR EGFR ncbigene_symbol EGFR 1956
Homo sapiens Primates Raf RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates Raf RAF famplex_relations ARAF 369
Homo sapiens Primates Raf RAF famplex_relations BRAF 673
Homo sapiens Primates Raf RAF famplex_relations RAF1 5894
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates Erk ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates Erk ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates Erk ERK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates Akt/PKB PKB ncbigene_synonym AKT1 207
Homo sapiens Primates Akt/PKB PKB ncbigene_synonym PTK2B 2185
Homo sapiens Primates Akt/PKB AKT famplex_relations AKT2 208
Homo sapiens Primates Akt/PKB AKT famplex_relations AKT3 10000
Drosophila melanogaster Invertebrates VEGF VEGF ncbigene_synonym Pvf1 32876
Drosophila melanogaster Invertebrates VEGF VEGF ncbigene_synonym Pvf2 33994
Drosophila melanogaster Invertebrates VEGF VEGF ncbigene_synonym Pvf3 33995
Drosophila melanogaster Invertebrates VEGF VEGF ncbigene_synonym Pvr 34127
Drosophila melanogaster Invertebrates (flt-1) FIT1 ncbigene_symbol Fit1 38488
Drosophila melanogaster Invertebrates EGFR EGFR ncbigene_symbol Egfr 37455
Drosophila melanogaster Invertebrates Raf RAF ncbigene_symbol Raf 31221
Drosophila melanogaster Invertebrates P38MAPK P38MAPK ncbigene_synonym p38b 34780
Drosophila melanogaster Invertebrates P38MAPK P38MAPK ncbigene_synonym p38a 42866
Drosophila melanogaster Invertebrates P38MAPK P38MAPK ncbigene_synonym p38c 2768679
Drosophila melanogaster Invertebrates Ras RAS ncbigene_symbol ras 43873
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras64B 38494
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Dsor1 31872
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Mtk 36708
Drosophila melanogaster Invertebrates Erk ERK ncbigene_synonym Erk7 31877
Drosophila melanogaster Invertebrates Erk ERK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym MKP-4 32963
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates Akt/PKB AKT/PKB ncbigene_synonym Akt 41957

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Cardiomyopathy NA
Lung cancer NA
Noonan syndrome NA