Gene Expression in Skeletal Muscle Biopsies from People with Type 2 Diabetes and Relatives: Differential Regulation of Insulin Signaling Pathways

The insulin signaling pathways were found to be significantly downregulated on the gene expression level using the program GenMAPP/MAPPFinder. Analysis criteria were set as described in the section. Underneath each section of the pathway, genes found to have an increased expression are depicted in red, and genes found to have a decreased expression are depicted in green. Figure adapted from GenMAPP.
Gene Expression in Skeletal Muscle Biopsies from People with Type 2 Diabetes and Relatives: Differential Regulation of Insulin Signaling Pathways
Download JPG
View figure at PMC Read paper at PMC Open at NDEx
PMC
NDEx

Publication

Gene Expression in Skeletal Muscle Biopsies from People with Type 2 Diabetes and Relatives: Differential Regulation of Insulin Signaling Pathways. (2009) Jane Palsgaard, et al. PLoS One. 2009;4(8):e6575. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates SLC2A4 SLC2A4 ncbigene_symbol SLC2A4 6517
Homo sapiens Primates INSR INSR ncbigene_symbol INSR 3643
Homo sapiens Primates INSR INSR famplex_relations IGF1R 3480
Homo sapiens Primates INSR INSR famplex_relations INSRR 3645
Homo sapiens Primates PIK3R1 PIK3R1 ncbigene_symbol PIK3R1 5295
Homo sapiens Primates PIK3CA PIK3CA ncbigene_symbol PIK3CA 5290
Homo sapiens Primates IRS2 IRS2 ncbigene_symbol IRS2 8660
Homo sapiens Primates RAF1 RAF1 ncbigene_symbol RAF1 5894
Homo sapiens Primates RAF1 RAF1 ncbigene_synonym RNASE3 6037
Homo sapiens Primates PIK3CD PIK3CD ncbigene_symbol PIK3CD 5293
Homo sapiens Primates PIK3CD PIK3CD ncbigene_synonym CLSTN1 22883
Homo sapiens Primates Tor TOR ncbigene_synonym RORC 6097
Homo sapiens Primates EIF4E EIF4E ncbigene_symbol EIF4E 1977
Homo sapiens Primates EIF4E EIF4E famplex_relations EIF4E2 9470
Homo sapiens Primates EIF4E EIF4E famplex_relations EIF4E3 317649
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates MAP MAP ncbigene_synonym SGSM3 27352
Homo sapiens Primates RHEB RHEB ncbigene_symbol RHEB 6009
Homo sapiens Primates RHEB RHEB ncbigene_synonym RHEBP1 6008
Homo sapiens Primates PDK/AKTSignaling PDK famplex_relations PDK1 5163
Homo sapiens Primates PDK/AKTSignaling PDK famplex_relations PDK2 5164
Homo sapiens Primates PDK/AKTSignaling PDK famplex_relations PDK3 5165
Homo sapiens Primates PDK/AKTSignaling PDK famplex_relations PDK4 5166
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates MAPK4 MAPK4 ncbigene_symbol MAPK4 5596
Homo sapiens Primates MAPK8 MAPK8 ncbigene_symbol MAPK8 5599
Homo sapiens Primates MAP4K4 MAP4K4 ncbigene_symbol MAP4K4 9448
Homo sapiens Primates PDPK1 PDPK1 ncbigene_symbol PDPK1 5170
Homo sapiens Primates MINK1 MINK1 ncbigene_symbol MINK1 50488
Homo sapiens Primates MAPK12 MAPK12 ncbigene_symbol MAPK12 6300
Homo sapiens Primates SRF SRF ncbigene_symbol SRF 6722
Homo sapiens Primates p90 P90 ncbigene_synonym CANX 821
Homo sapiens Primates p90 P90 ncbigene_synonym TFRC 7037
Homo sapiens Primates p90 P90 ncbigene_synonym CIP2A 57650
Homo sapiens Primates p90 P90 ncbigene_synonym CCDC8 83987
Homo sapiens Primates Rsk RSK ncbigene_synonym RPS6KA1 6195
Homo sapiens Primates Rsk RSK ncbigene_synonym RPS6KA2 6196
Homo sapiens Primates Rsk RSK ncbigene_synonym RPS6KA3 6197
Homo sapiens Primates Rsk RSK famplex_relations RPS6KA4 8986
Homo sapiens Primates Rsk RSK famplex_relations RPS6KA5 9252
Homo sapiens Primates Rsk RSK famplex_relations RPS6KA6 27330
Homo sapiens Primates Rsk RSK famplex_relations RPS6KB1 6198
Homo sapiens Primates Rsk RSK famplex_relations RPS6KB2 6199
Homo sapiens Primates VAMP2 VAMP2 ncbigene_symbol VAMP2 6844
Homo sapiens Primates SORBS1 SORBS1 ncbigene_symbol SORBS1 10580
Homo sapiens Primates EHD1 EHD1 ncbigene_symbol EHD1 10938
Homo sapiens Primates CBLC CBLC ncbigene_symbol CBLC 23624
Homo sapiens Primates CBLC CBLC ncbigene_synonym MMACHC 25974
Homo sapiens Primates SNX26 SNX26 ncbigene_synonym ARHGAP33 115703
Homo sapiens Primates RAPGEF1 RAPGEF1 ncbigene_symbol RAPGEF1 2889
Homo sapiens Primates PTPN11 PTPN11 ncbigene_symbol PTPN11 5781
Homo sapiens Primates socs3 SOCS3 ncbigene_symbol SOCS3 9021
Homo sapiens Primates PRKCA PRKCA ncbigene_symbol PRKCA 5578
Homo sapiens Primates LIPE LIPE ncbigene_symbol LIPE 3991
Homo sapiens Primates PFKL PFKL ncbigene_symbol PFKL 5211
Homo sapiens Primates PRKCQ PRKCQ ncbigene_symbol PRKCQ 5588
Homo sapiens Primates IKBKB IKBKB ncbigene_symbol IKBKB 3551
Homo sapiens Primates GYS1 GYS1 ncbigene_symbol GYS1 2997

Chemical mentions

Word Match MeSH Name ChEBI
Glucose Glucose mesh:D005947 D-glucopyranose chebi:4167

Disease mentions

Word Match MeSH Name DOID
Diabetes mellitus NA