Model for the role of FANCM in the DNA damage response

Model for the role of FANCM in the DNA damage response. (A) Model for the role of FANCM in the FA pathway and crosslink repair in the DNA damage response. () The helicase or nuclease domain can target the FA core complex to a replication block at a DNA crosslink. () The core complex can stimulate FANCD2 monoubiquitination, perhaps by being in close proximity to its substrates FANCD2 and FANCI. () An ATP driven conformational change may enable the FANCM complex to recruit additional DNA repair proteins that carry out crosslink repair. (B) A cartoon of the FANCM protein divided into the three domains systematically dissected in this article. Each of the domains confers distinct functions to FANCM in the DNA damage response. (C) FANCM helicase suppresses crossovers by dissolving D-loops, by acting early to suppress D loop formation FANCM may prevent the formation of Holliday junction, which are then resolved by crossover.

Publication

The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair. (2009) Ivan V. Rosado, et al. Nucleic Acids Res. 2009 Jul;37(13):4360-4370. Figure: F6. All organisms Drosophila melanogaster Homo sapiens

Disease mentions