Estradiol-17B, prostaglandin E2 (PGE2) and the prostaglandin E2 receptor are involved in PGE2 positive feedback loop in the porcine endometrium

Potential mechanism involved in increasing luteoprotective PGE2 level and the PGE2:PGF2α ratio during the maternal recognition of pregnancy in the pig - involvement of estradiol-17β, PGE2 and endometrial PGE2 receptors (PTGER2) in PGE2 positive feedback loop in the porcine endometrium.The primary conceptus signal, E2 and another conceptus factor - PGE2 regulate the protein expression of endometrial PG synthesis pathway enzymes to favor production of luteoprotective PGE2. E2 up-regulates PTGS2 and PGE synthase protein expression and down-regulates endometrial PGFS and CBR1 protein concentrations increasing PGE2 secretion and the PGE2:PGF2α ratio. PGE2 acts through endometrial PTGER2 receptor, activates cAMP signaling pathway and elevates the mRNA and protein expression of enzymes involved in PGE2synthesis (PTGS2 and mPGES-1) and its own secretion in the endometrium.

Publication

Estradiol-17β, prostaglandin E2 (PGE2) and the prostaglandin E2 receptor are involved in PGE2 positive feedback loop in the porcine endometrium. (2009) Agnieszka Waclawik, et al. Endocrinology. 2009 Aug;150(8):3823-3832. Figure: F6. All organisms Homo sapiens Rattus norvegicus Mus musculus Sus scrofa Bos taurus Ovis aries Oryctolagus cuniculus

Disease mentions