Production of Superoxide Anions by Keratinocytes Initiates P. acnes-Induced Inflammation of the Skin

Surface components of P. acnes are recognized by both CD36 and TLR-2. CD36 triggers the production of O2•− through the NADPH oxidase pathway (NOX) and combines with NO to form peroxinitrites which, in turn, activate p38 and ERK MAPKs, thus contributing to IL-8 production. In parallel, IL-8 production is activated through the TLR-2 signalling pathway.
Production of Superoxide Anions by Keratinocytes Initiates P. acnes-Induced Inflammation of the Skin
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Production of Superoxide Anions by Keratinocytes Initiates P. acnes-Induced Inflammation of the Skin. (2009) Philippe A. Grange, et al. PLoS Pathog. 2009 Jul;5(7):e1000527. Figure: F11.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents IL-8 IL8 ncbigene_synonym Cxcl15 20309
Mus musculus Rodents Ab AB ncbigene_synonym App 11820
Mus musculus Rodents Ab AB ncbigene_synonym H2-Ab1 14961
Mus musculus Rodents CD36 CD36 ncbigene_symbol Cd36 12491
Mus musculus Rodents CD36 CD36 ncbigene_synonym Scarb1 20778
Mus musculus Rodents Nox1 NOX1 ncbigene_symbol Nox1 237038
Mus musculus Rodents JNK JNK ncbigene_synonym Mapk8 26419
Mus musculus Rodents p38,ERK,JNK ERK ncbigene_synonym Ephb2 13844
Mus musculus Rodents p38,ERK,JNK ERK ncbigene_synonym Mapk1 26413
Mus musculus Rodents p38,ERK,JNK P38 ncbigene_synonym Crk 12928
Mus musculus Rodents p38,ERK,JNK P38 ncbigene_synonym Grap2 17444
Mus musculus Rodents p38,ERK,JNK P38 ncbigene_synonym Syp 20977
Mus musculus Rodents p38,ERK,JNK P38 ncbigene_synonym Mapk14 26416
Mus musculus Rodents p38,ERK,JNK P38 ncbigene_synonym Ahsa1 217737
Mus musculus Rodents IKB IKB ncbigene_synonym Nfkbib 18036
Mus musculus Rodents NF-kB NF-KB ncbigene_synonym Nfkb1 18033
Mus musculus Rodents DDC DDC ncbigene_symbol Ddc 13195
Homo sapiens Primates IL-8 IL8 ncbigene_synonym CXCL8 3576
Homo sapiens Primates Ab AB ncbigene_synonym APP 351
Homo sapiens Primates Ab AB ncbigene_synonym SUCLA2 8803
Homo sapiens Primates CD36 CD36 ncbigene_symbol CD36 948
Homo sapiens Primates Nox1 NOX1 ncbigene_symbol NOX1 27035
Homo sapiens Primates JNK JNK ncbigene_synonym MAPK8 5599
Homo sapiens Primates JNK JNK famplex_relations MAPK9 5601
Homo sapiens Primates JNK JNK famplex_relations MAPK10 5602
Homo sapiens Primates p38,ERK,JNK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates p38,ERK,JNK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates p38,ERK,JNK ERK famplex_relations MAPK3 5595
Homo sapiens Primates p38,ERK,JNK P38 ncbigene_synonym CRK 1398
Homo sapiens Primates p38,ERK,JNK P38 ncbigene_synonym MAPK14 1432
Homo sapiens Primates p38,ERK,JNK P38 ncbigene_synonym AIMP2 7965
Homo sapiens Primates p38,ERK,JNK P38 ncbigene_synonym GRAP2 9402
Homo sapiens Primates p38,ERK,JNK P38 ncbigene_synonym AHSA1 10598
Homo sapiens Primates p38,ERK,JNK P38 ncbigene_synonym POLDIP2 26073
Homo sapiens Primates p38,ERK,JNK P38 famplex_relations MAPK11 5600
Homo sapiens Primates p38,ERK,JNK P38 famplex_relations MAPK12 6300
Homo sapiens Primates p38,ERK,JNK P38 famplex_relations MAPK13 5603
Homo sapiens Primates NF-kB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates DDC DDC ncbigene_symbol DDC 1644
Bos taurus Mammals IL-8 IL-8 ncbigene_synonym CXCL8 280828
Bos taurus Mammals CD36 CD36 ncbigene_symbol CD36 281052
Bos taurus Mammals Nox1 NOX1 ncbigene_symbol NOX1 521681
Bos taurus Mammals p38,ERK,JNK P38 ncbigene_synonym MAPK14 534492
Bos taurus Mammals DDC DDC ncbigene_symbol DDC 280762
Capra hircus Mammals IL-8 IL8 ncbigene_synonym CXCL8 102178438
Capra hircus Mammals CD36 CD36 ncbigene_symbol CD36 100860958
Capra hircus Mammals Nox1 NOX1 ncbigene_symbol NOX1 102178048
Capra hircus Mammals DDC DDC ncbigene_symbol DDC 102169726
Drosophila melanogaster Invertebrates Ab AB ncbigene_symbol ab 34560
Drosophila melanogaster Invertebrates Ab AB ncbigene_synonym Appl 31002
Drosophila melanogaster Invertebrates CD36 CD36 ncbigene_synonym crq 33219
Drosophila melanogaster Invertebrates Nox NOX ncbigene_symbol Nox 5740310
Drosophila melanogaster Invertebrates JNK JNK ncbigene_synonym bsk 44801
Drosophila melanogaster Invertebrates p38,ERK,JNK ERK ncbigene_synonym Erk7 31877
Drosophila melanogaster Invertebrates p38,ERK,JNK ERK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates p38,ERK,JNK P38 ncbigene_synonym lic 32257
Drosophila melanogaster Invertebrates p38,ERK,JNK P38 ncbigene_synonym p38b 34780
Drosophila melanogaster Invertebrates p38,ERK,JNK P38 ncbigene_synonym Nurf-38 37922
Drosophila melanogaster Invertebrates p38,ERK,JNK P38 ncbigene_synonym Ebp 38009
Drosophila melanogaster Invertebrates p38,ERK,JNK P38 ncbigene_synonym AIMP2 39690
Drosophila melanogaster Invertebrates p38,ERK,JNK P38 ncbigene_synonym p38a 42866
Drosophila melanogaster Invertebrates p38,ERK,JNK P38 ncbigene_synonym Hrb87F 48535
Drosophila melanogaster Invertebrates p38,ERK,JNK P38 ncbigene_synonym p38c 2768679
Drosophila melanogaster Invertebrates NF-kB NF-KB ncbigene_synonym Dif 35045
Drosophila melanogaster Invertebrates NF-kB NF-KB ncbigene_synonym dl 35047
Drosophila melanogaster Invertebrates NF-kB NF-KB ncbigene_synonym Rel 41087
Drosophila melanogaster Invertebrates DDC DDC ncbigene_symbol Ddc 35190
Danio rerio Vertebrates IL-8 IL8 ncbigene_synonym cxcl8a 100002946
Danio rerio Vertebrates CD36 CD36 ncbigene_symbol cd36 436636
Danio rerio Vertebrates Nox1 NOX1 ncbigene_symbol nox1 555604
Danio rerio Vertebrates JNK JNK ncbigene_synonym mapk8b 65236
Danio rerio Vertebrates p38,ERK,JNK P38 ncbigene_synonym mapk14a 65237
Danio rerio Vertebrates DDC DDC ncbigene_symbol ddc 406651

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID