Scheme indicating expression of Tcf4 proteins and effects of Wnt–Beta-catenin signaling to inhibit the transition from premyelinating to mature oligodendrocyte

Scheme indicating expression of Tcf4 proteins and effects of Wnt–β-catenin signaling to inhibit the transition from premyelinating to mature oligodendrocyte. Our genetic evidence is consistent with APC (CC1, a known marker of mature oligodendrocytes) acting to promote differentiation. HYCCIN, a Wnt-repressed target () with essential roles in human myelination (), is expressed in rodent oligodendrocytes and down-regulated in Olig2cre/DA-Cat mice (Supplemental Fig. 8). Temporal expression of Tcf4 and markers of oligodendrocyte lineage tested in this study is shown. (Pre OL) Premyelinating oligodendrocyte; (OL) oligodendrocyte.
Scheme indicating expression of Tcf4 proteins and effects of Wnt–Beta-catenin signaling to inhibit the transition from premyelinating to mature oligodendrocyte
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Publication

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. (2009) Stephen P.J. Fancy, et al. Genes Dev. 2009 Jul 1;23(13):1571-1585. Figure: F8.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates APC APC ncbigene_symbol APC 324
Homo sapiens Primates APC APC ncbigene_synonym PROC 5624
Homo sapiens Primates Tcf4 TCF4 ncbigene_symbol TCF4 6925
Homo sapiens Primates Tcf4 TCF4 ncbigene_synonym TCF7L2 6934
Homo sapiens Primates Wnt WNT famplex_relations WNT1 7471
Homo sapiens Primates Wnt WNT famplex_relations WNT2 7472
Homo sapiens Primates Wnt WNT famplex_relations WNT2B 7482
Homo sapiens Primates Wnt WNT famplex_relations WNT3 7473
Homo sapiens Primates Wnt WNT famplex_relations WNT3A 89780
Homo sapiens Primates Wnt WNT famplex_relations WNT4 54361
Homo sapiens Primates Wnt WNT famplex_relations WNT6 7475
Homo sapiens Primates Wnt WNT famplex_relations WNT7A 7476
Homo sapiens Primates Wnt WNT famplex_relations WNT7B 7477
Homo sapiens Primates Wnt WNT famplex_relations WNT8A 7478
Homo sapiens Primates Wnt WNT famplex_relations WNT8B 7479
Homo sapiens Primates Wnt WNT famplex_relations WNT9A 7483
Homo sapiens Primates Wnt WNT famplex_relations WNT9B 7484
Homo sapiens Primates Wnt WNT famplex_relations WNT10A 80326
Homo sapiens Primates Wnt WNT famplex_relations WNT10B 7480
Homo sapiens Primates Wnt WNT famplex_relations WNT11 7481
Homo sapiens Primates Wnt WNT famplex_relations WNT16 51384
Homo sapiens Primates Wnt WNT famplex_relations WNT5A 7474
Homo sapiens Primates Wnt WNT famplex_relations WNT5B 81029
Homo sapiens Primates PDGFRA PDGFRA ncbigene_symbol PDGFRA 5156
Homo sapiens Primates Olig2 OLIG2 ncbigene_symbol OLIG2 10215
Homo sapiens Primates Nkx2.2 NKX2.2 ncbigene_synonym NKX2-2 4821
Homo sapiens Primates Olig1 OLIG1 ncbigene_symbol OLIG1 116448
Homo sapiens Primates (CC1) CC1 ncbigene_synonym CCL14 6358
Homo sapiens Primates (CC1) CC1 ncbigene_synonym RB1CC1 9821
Homo sapiens Primates PLP PLP ncbigene_synonym PLP1 5354
Homo sapiens Primates PLP PLP ncbigene_synonym PTHLH 5744
Homo sapiens Primates PLP PLP ncbigene_synonym PRDX5 25824
Homo sapiens Primates PLP PLP ncbigene_synonym PDXP 57026
Danio rerio Vertebrates APC APC ncbigene_symbol apc 386762
Danio rerio Vertebrates Tcf4 TCF4 ncbigene_symbol tcf4 100526651
Danio rerio Vertebrates Tcf4 TCF4 ncbigene_synonym tcf7l2 30510
Danio rerio Vertebrates PDGFRA PDGFRA ncbigene_symbol pdgfra 386856
Danio rerio Vertebrates Olig2 OLIG2 ncbigene_symbol olig2 325288
Danio rerio Vertebrates Nkx2.2 NKX2.2 ncbigene_synonym nkx2.2a 30697
Danio rerio Vertebrates Olig1 OLIG1 ncbigene_symbol olig1 100001484

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA