Immune activation induced by Beta-glucans

Immune activation induced by β-glucans. β-glucans can act on a variety of membrane receptors found on the immune cells. It may act singly or in combine with other ligands. Various signaling pathway are activated and their respective simplified downstream signaling molecules are shown. The reactors cells include monocytes, macrophages, dendritic cells, natural killer cells and neutrophils. Their corresponding surface receptors are listed. The immunomodulatory functions induced by β-glucans involve both innate and adaptive immune response. β-glucans also enhance opsonic and non-opsonic phagocytosis and trigger a cascade of cytokines release, such as tumor necrosis factor(TNF)-α and various types of interleukins (ILs).
Immune activation induced by Beta-glucans
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Publication

The effects of β-glucan on human immune and cancer cells. (2009) Godfrey Chi-Fung Chan, et al. J Hematol Oncol. 2009;2:25-25. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates Dectin-1 DECTIN1 ncbigene_synonym CLEC7A 64581
Homo sapiens Primates CR3 CR3 ncbigene_synonym CRIPTO3 6998
Homo sapiens Primates TLR2/6 TLR2 ncbigene_symbol TLR2 7097
Homo sapiens Primates TLR2/6 TLR6 ncbigene_symbol TLR6 10333
Homo sapiens Primates TLR4 TLR4 ncbigene_symbol TLR4 7099
Homo sapiens Primates MIP2 MIP2 ncbigene_synonym CXCL2 2920
Homo sapiens Primates MIP2 MIP2 ncbigene_synonym WDR26 80232
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates syk SYK ncbigene_symbol SYK 6850
Homo sapiens Primates MyD88 MYD88 ncbigene_symbol MYD88 4615
Homo sapiens Primates TRAF-6 TRAF6 ncbigene_symbol TRAF6 7189
Homo sapiens Primates PKC PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKC PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKC PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKC PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKC PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKC PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKC PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKC PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKC PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKC PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKC PKC famplex_relations PRKD3 23683
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates card9 CARD9 ncbigene_symbol CARD9 64170
Homo sapiens Primates NFAT NFAT famplex_relations NFATC1 4772
Homo sapiens Primates NFAT NFAT famplex_relations NFATC2 4773
Homo sapiens Primates NFAT NFAT famplex_relations NFATC3 4775
Homo sapiens Primates NFAT NFAT famplex_relations NFATC4 4776
Homo sapiens Primates NFAT NFAT famplex_relations NFAT5 10725
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates TLR TLR famplex_relations TLR1 7096
Homo sapiens Primates TLR TLR famplex_relations TLR3 7098
Homo sapiens Primates TLR TLR famplex_relations TLR5 7100
Homo sapiens Primates TLR TLR famplex_relations TLR7 51284
Homo sapiens Primates TLR TLR famplex_relations TLR8 51311
Homo sapiens Primates TLR TLR famplex_relations TLR9 54106
Homo sapiens Primates TLR TLR famplex_relations TLR10 81793
Homo sapiens Primates (TNFa,IL-2, IL-2 ncbigene_synonym IL2 3558
Homo sapiens Primates (TNFa, TNFA ncbigene_synonym TNF 7124
Homo sapiens Primates IL-10, IL-10 ncbigene_synonym IL10 3586
Homo sapiens Primates IL-12) IL12 famplex_relations IL12A 3592
Homo sapiens Primates IL-12) IL12 famplex_relations IL12B 3593
Homo sapiens Primates killer KILLER ncbigene_synonym TNFRSF10B 8795
Homo sapiens Primates cll CL1 ncbigene_synonym DCLK1 9201
Homo sapiens Primates cll CL1 ncbigene_synonym ADGRL1 22859
Homo sapiens Primates cll CLI ncbigene_synonym CLU 1191
Homo sapiens Primates cll C11 ncbigene_synonym AKR1C4 1109
Homo sapiens Primates cll C11 ncbigene_synonym GZMB 3002
Homo sapiens Primates cll C11 ncbigene_synonym POLR3K 51728
Homo sapiens Primates Bcll BCL1 ncbigene_synonym CCND1 595
Drosophila melanogaster Invertebrates CR3 CR3 ncbigene_symbol cr-3 248172
Drosophila melanogaster Invertebrates TLR2/6 TLR2 ncbigene_symbol tlr-2 44349
Drosophila melanogaster Invertebrates TLR4 TLR4 ncbigene_synonym Toll-4 34235
Drosophila melanogaster Invertebrates MIP2 MIP2 ncbigene_synonym Mip 39933
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates syk SYK ncbigene_synonym Shark 44353
Drosophila melanogaster Invertebrates MyD88 MYD88 ncbigene_symbol Myd88 35956
Drosophila melanogaster Invertebrates TRAF-6 TRAF6 ncbigene_symbol Traf6 31746
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym inaC 36897
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym Pkc98E 43428
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym aPKC 47594
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym Pkc53E 48311
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym MKP-4 32963
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym p38b 34780
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates NFAT NFAT ncbigene_symbol NFAT 32321
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym Dif 35045
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym dl 35047
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym Rel 41087
Drosophila melanogaster Invertebrates TLR TLR ncbigene_synonym 18w 37277
Drosophila melanogaster Invertebrates TLR TLR ncbigene_synonym tok 42944
Drosophila melanogaster Invertebrates (TNFa,IL-2, TNFA ncbigene_synonym egr 36054
Drosophila melanogaster Invertebrates cll CLL ncbigene_synonym C15 42544
Drosophila melanogaster Invertebrates cll CLI ncbigene_symbol Cli 5657022
Drosophila melanogaster Invertebrates cll CLI ncbigene_synonym eya 33916
Danio rerio Vertebrates TLR2/6 TLR2 ncbigene_symbol tlr2 403125
Danio rerio Vertebrates MIP2 MIP2 ncbigene_synonym mipb 553420
Danio rerio Vertebrates syk SYK ncbigene_symbol syk 405769
Danio rerio Vertebrates MyD88 MYD88 ncbigene_symbol myd88 403145
Danio rerio Vertebrates TRAF-6 TRAF6 ncbigene_symbol traf6 554561
Danio rerio Vertebrates card9 CARD9 ncbigene_symbol card9 796425
Danio rerio Vertebrates (TNFa,IL-2, TNFA ncbigene_symbol tnfa 405785
Danio rerio Vertebrates (TNFa,IL-2, TNFA ncbigene_synonym tnfb 554167
Danio rerio Vertebrates IL-10, IL10 ncbigene_symbol il10 553957

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA