The ER–mitochondria apoptotic signalling pathway operating in cells devoid of mitochondrial BAK and BAX, and of ER-located BAX

Schematic representation of the ER–mitochondria apoptotic signalling pathway operating in cells devoid of mitochondrial BAK and BAX, and of ER-located BAX. The high concentration of Ca2+ favours the IRE1α–TRAF2–JNK pathway, and enables mitochondrial susceptibility to cell death in these cells. See text for details.
The ER–mitochondria apoptotic signalling pathway operating in cells devoid of mitochondrial BAK and BAX, and of ER-located BAX
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Publication

When separation means death: killing through the mitochondria, but starting from the endoplasmic reticulum. (2009) Violeta Lamarca, et al. EMBO J. 2009 Jun 17;28(12):1681-1683. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates TRAF2 TRAF2 ncbigene_symbol TRAF2 7186
Homo sapiens Primates TRAF2 TRAF2 ncbigene_synonym TANK 10010
Homo sapiens Primates JNK JNK ncbigene_synonym MAPK8 5599
Homo sapiens Primates JNK JNK famplex_relations MAPK9 5601
Homo sapiens Primates JNK JNK famplex_relations MAPK10 5602
Homo sapiens Primates BCL-2 BCL-2 ncbigene_synonym BCL2 596
Homo sapiens Primates BAX/BAK BAK ncbigene_synonym BAK1 578
Homo sapiens Primates BAX/BAK BAX ncbigene_symbol BAX 581
Homo sapiens Primates BAD BAD ncbigene_symbol BAD 572
Homo sapiens Primates IP3R IP3R ncbigene_synonym ITPR1 3708
Homo sapiens Primates IP3R IP3R ncbigene_synonym ITPR3 3710
Homo sapiens Primates PUMA PUMA ncbigene_synonym BBC3 27113
Homo sapiens Primates BIM BIM ncbigene_synonym BCL2L11 10018
Homo sapiens Primates Caspase CASPASE famplex_relations CASP1 834
Homo sapiens Primates Caspase CASPASE famplex_relations CASP2 835
Homo sapiens Primates Caspase CASPASE famplex_relations CASP4 837
Homo sapiens Primates Caspase CASPASE famplex_relations CASP5 838
Homo sapiens Primates Caspase CASPASE famplex_relations CASP6 839
Homo sapiens Primates Caspase CASPASE famplex_relations CASP8 841
Homo sapiens Primates Caspase CASPASE famplex_relations CASP9 842
Homo sapiens Primates Caspase CASPASE famplex_relations CASP10 843
Homo sapiens Primates Caspase CASPASE famplex_relations CASP12 100506742
Homo sapiens Primates Caspase CASPASE famplex_relations CASP14 23581
Homo sapiens Primates Caspase CASPASE famplex_relations CASP3 836
Homo sapiens Primates Caspase CASPASE famplex_relations CASP7 840

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID