Synergistic combinations of signaling pathway inhibitors: Mechanisms for improved cancer therapy

Kinase inhibitors that modulate the cell cycle have frequently been combined with toxic drugs and/or radiation which cause DNA damage. This will lead to inappropriate cell cycle progression with damage DNA and result in tumor cell death. Inhibition of PARP1 ADP ribosylation activity suppresses the ability of DNA damage to activate ATM/ATR as well as increase DNA repair processes.
Synergistic combinations of signaling pathway inhibitors: Mechanisms for improved cancer therapy
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Synergistic combinations of signaling pathway inhibitors: Mechanisms for improved cancer therapy. () Paul Dent, et al. Drug Resist Updat. ;12(3):65-73. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates CDK CDK famplex_relations CDKL1 8814
Homo sapiens Primates CDK CDK famplex_relations CDKL2 8999
Homo sapiens Primates CDK CDK famplex_relations CDKL3 51265
Homo sapiens Primates CDK CDK famplex_relations CDKL4 344387
Homo sapiens Primates CDK CDK famplex_relations CDKL5 6792
Homo sapiens Primates CDK CDK famplex_relations CDK3 1018
Homo sapiens Primates CDK CDK famplex_relations CDK4 1019
Homo sapiens Primates CDK CDK famplex_relations CDK5 1020
Homo sapiens Primates CDK CDK famplex_relations CDK6 1021
Homo sapiens Primates CDK CDK famplex_relations CDK7 1022
Homo sapiens Primates CDK CDK famplex_relations CDK8 1024
Homo sapiens Primates CDK CDK famplex_relations CDK9 1025
Homo sapiens Primates CDK CDK famplex_relations CDK10 8558
Homo sapiens Primates CDK CDK famplex_relations CDK11A 728642
Homo sapiens Primates CDK CDK famplex_relations CDK11B 984
Homo sapiens Primates CDK CDK famplex_relations CDK12 51755
Homo sapiens Primates CDK CDK famplex_relations CDK13 8621
Homo sapiens Primates CDK CDK famplex_relations CDK14 5218
Homo sapiens Primates CDK CDK famplex_relations CDK15 65061
Homo sapiens Primates CDK CDK famplex_relations CDK16 5127
Homo sapiens Primates CDK CDK famplex_relations CDK17 5128
Homo sapiens Primates CDK CDK famplex_relations CDK18 5129
Homo sapiens Primates CDK CDK famplex_relations CDK19 23097
Homo sapiens Primates CDK CDK famplex_relations CDK20 23552
Homo sapiens Primates CDK CDK famplex_relations CDK1 983
Homo sapiens Primates CDK CDK famplex_relations CDK2 1017
Homo sapiens Primates p-TEFB) PTEFB famplex_relations CCNK 8812
Homo sapiens Primates p-TEFB) PTEFB famplex_relations CCNT1 904
Homo sapiens Primates p-TEFB) PTEFB famplex_relations CCNT2 905
Homo sapiens Primates p-TEFB) PTEFB famplex_relations HEXIM1 10614
Homo sapiens Primates p-TEFB) PTEFB famplex_relations HEXIM2 124790
Homo sapiens Primates PARP1 PARP1 ncbigene_symbol PARP1 142
Homo sapiens Primates ATR ATR ncbigene_symbol ATR 545
Homo sapiens Primates ATR ATR ncbigene_synonym ANTXR1 84168
Homo sapiens Primates ATR ATR ncbigene_synonym MMAB 326625
Homo sapiens Primates ATR ATR ncbigene_synonym SERPINA2 390502
Homo sapiens Primates ATM/ATR ATM ncbigene_symbol ATM 472
Homo sapiens Primates Cdc25C CDC25C ncbigene_symbol CDC25C 995
Homo sapiens Primates Chk1 CHK1 ncbigene_synonym CHEK1 1111
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Mus musculus Rodents PARP1 PARP1 ncbigene_symbol Parp1 11545
Mus musculus Rodents ATR ATR ncbigene_symbol Atr 245000
Mus musculus Rodents ATR ATR ncbigene_synonym Mmab 77697
Mus musculus Rodents ATM/ATR ATM ncbigene_symbol Atm 11920
Mus musculus Rodents ATM/ATR ATM ncbigene_synonym Tpm1 22003
Mus musculus Rodents Cdc25C CDC25C ncbigene_symbol Cdc25c 12532
Mus musculus Rodents Chk1 CHK1 ncbigene_synonym Chek1 12649
Mus musculus Rodents PI3K PI3K ncbigene_synonym Pik3r1 18708
Danio rerio Vertebrates p-TEFB) TEFB ncbigene_symbol tefb 553686
Danio rerio Vertebrates p-TEFB) TEFB ncbigene_synonym tefa 30674
Danio rerio Vertebrates PARP1 PARP1 ncbigene_symbol parp1 560788
Danio rerio Vertebrates ATR ATR ncbigene_symbol atr 567770
Danio rerio Vertebrates ATM/ATR ATM ncbigene_symbol atm 403064
Danio rerio Vertebrates kinase KINASE ncbigene_synonym pak2a 266749
Danio rerio Vertebrates kinase KINASE ncbigene_synonym itpka 368717

Chemical mentions

Word Match MeSH Name ChEBI
Flavopiridol alvocidib mesh:C077990 alvocidib chebi:47344
MK0457 NA mesh:C484810
KU55933 NA mesh:C495818
AZD2281 olaparib mesh:C531550 olaparib chebi:83766
AZD7762 NA mesh:C532363

Disease mentions

Word Match MeSH Name DOID