ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE

Potential sites of action of small molecular weight inhibitors are indicated. In some cases inhibitors will suppress growth, apoptotic and cell cycle regulatory pathways. This diagram serves to illustrate the concept that targeting Raf/MEK/ERK and PI3K/Akt can have dramatic effects on many growth regulatory molecules. Proteins inactivated by S/T phosphorylation induced by the PI3K/Akt pathway are shown in black circles with white P in a black circle.
ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE
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ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE. () James A. McCubrey, et al. Biochim Biophys Acta. ;1773(8):1263-1284. Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates and AND ncbigene_synonym CkIIbeta 32132
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Andorra 32798
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Anp 43595
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Acam 44913
Drosophila melanogaster Invertebrates TargetingRafMEKandPISKPDK/Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates PDK PDK ncbigene_symbol Pdk 35970
Drosophila melanogaster Invertebrates PDK PDK ncbigene_synonym Pdk1 38017
Drosophila melanogaster Invertebrates PTEN PTEN ncbigene_symbol Pten 43991
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates Raf RAF ncbigene_symbol Raf 31221
Drosophila melanogaster Invertebrates p85 P85 ncbigene_synonym Myb 32543
Drosophila melanogaster Invertebrates p85 P85 ncbigene_synonym Taf5 47900
Drosophila melanogaster Invertebrates Sho SHO ncbigene_symbol sho 252636
Drosophila melanogaster Invertebrates Grb2 GRB2 ncbigene_synonym drk 36497
Drosophila melanogaster Invertebrates (Src SRC ncbigene_synonym Src42A 35524
Drosophila melanogaster Invertebrates (Src SRC ncbigene_synonym Csk 41398
Drosophila melanogaster Invertebrates (Src SRC ncbigene_synonym Src64B 48973
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Dsor1 31872
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Mtk 36708
Drosophila melanogaster Invertebrates SoS SOS ncbigene_symbol Sos 34790
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym Erk7 31877
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates GSK-3 GSK-3 ncbigene_synonym sgg 31248
Drosophila melanogaster Invertebrates p21 P21 ncbigene_synonym dap 36001
Drosophila melanogaster Invertebrates IKK IKK ncbigene_synonym IKKepsilon 35329
Drosophila melanogaster Invertebrates IKK IKK ncbigene_synonym key 37967
Drosophila melanogaster Invertebrates IKK IKK ncbigene_synonym IKKbeta 44432
Drosophila melanogaster Invertebrates FOXO FOXO ncbigene_symbol foxo 41709
Drosophila melanogaster Invertebrates Bad BAD ncbigene_synonym cass 35053
Drosophila melanogaster Invertebrates Cycle CYCLE ncbigene_synonym CycE 34924
Drosophila melanogaster Invertebrates Cycle CYCLE ncbigene_synonym cyc 40162
Homo sapiens Primates TargetingRafMEKandPISKPDK/Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates TargetingRafMEKandPISKPDK/Akt AKT famplex_relations AKT2 208
Homo sapiens Primates TargetingRafMEKandPISKPDK/Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates PDK PDK famplex_relations PDK1 5163
Homo sapiens Primates PDK PDK famplex_relations PDK2 5164
Homo sapiens Primates PDK PDK famplex_relations PDK3 5165
Homo sapiens Primates PDK PDK famplex_relations PDK4 5166
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates Raf RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates Raf RAF famplex_relations ARAF 369
Homo sapiens Primates Raf RAF famplex_relations BRAF 673
Homo sapiens Primates Raf RAF famplex_relations RAF1 5894
Homo sapiens Primates PDK1 PDK1 ncbigene_synonym PDPK1 5170
Homo sapiens Primates p85 P85 ncbigene_synonym ARHGEF7 8874
Homo sapiens Primates p85 P85 ncbigene_synonym CBFA2T2 9139
Homo sapiens Primates p85 P85 ncbigene_synonym PPP1R13B 23368
Homo sapiens Primates p85 P85 ncbigene_synonym PPP1R12C 54776
Homo sapiens Primates Sho SHO ncbigene_synonym SPRN 503542
Homo sapiens Primates Grb2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates (Src SRC ncbigene_symbol SRC 6714
Homo sapiens Primates (Src SRC famplex_relations FGR 2268
Homo sapiens Primates (Src SRC famplex_relations FYN 2534
Homo sapiens Primates (Src SRC famplex_relations YES1 7525
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates SoS SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates SoS SOS famplex_relations SOS1 6654
Homo sapiens Primates SoS SOS famplex_relations SOS2 6655
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates GSK-3 GSK3 famplex_relations GSK3A 2931
Homo sapiens Primates GSK-3 GSK3 famplex_relations GSK3B 2932
Homo sapiens Primates p21 P21 ncbigene_synonym CDKN1A 1026
Homo sapiens Primates p21 P21 ncbigene_synonym TCEAL1 9338
Homo sapiens Primates p21 P21 ncbigene_synonym NSG1 27065
Homo sapiens Primates p21 P21 ncbigene_synonym H3P16 644914
Homo sapiens Primates IKK IKK famplex_relations CHUK 1147
Homo sapiens Primates IKK IKK famplex_relations IKBKB 3551
Homo sapiens Primates IKK IKK famplex_relations IKBKG 8517
Homo sapiens Primates IKK IKK famplex_relations IKBKE 9641
Homo sapiens Primates IKK IKK famplex_relations TBK1 29110
Homo sapiens Primates FOXO FOXO famplex_relations FOXO1 2308
Homo sapiens Primates FOXO FOXO famplex_relations FOXO3 2309
Homo sapiens Primates FOXO FOXO famplex_relations FOXO4 4303
Homo sapiens Primates FOXO FOXO famplex_relations FOXO6 100132074
Homo sapiens Primates Mcl-1 MCL-1 ncbigene_synonym MCL1 4170
Homo sapiens Primates Bim BIM ncbigene_synonym BCL2L11 10018
Homo sapiens Primates Bad BAD ncbigene_symbol BAD 572

Chemical mentions

Word Match MeSH Name ChEBI
Geldanamycin NA mesh:C001277

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Noonan syndrome NA