Glycerol phosphate pathway for de novo triacylglycerol (TAG) and glycerophospholipid synthesis

Glycerol phosphate pathway for de novo triacylglycerol (TAG) and glycerophospholipid synthesis. GPAT, glycerol-3-phosphate acyltransferase; LPA, lysophosphatidic acid; AGPAT, 1-acylglycerol-3-phosphate acyltransferase; PI, phosphatidylinositol; PG, phosphatidylglycerol; CL, cardiolipin; PA, phosphatidic acid; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PS, phosphatidylserine; DAG, diacylglycerol; DGAT, diacylglycerol acyltransferase.
Glycerol phosphate pathway for de novo triacylglycerol (TAG) and glycerophospholipid synthesis
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Publication

Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis. (2009) Kazuharu Takeuchi, et al. Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1195-E1209. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents GPAT1 GPAT1 ncbigene_synonym Gpam 14732
Mus musculus Rodents GPAT3 GPAT3 ncbigene_symbol Gpat3 231510
Mus musculus Rodents GPAT2 GPAT2 ncbigene_symbol Gpat2 215456
Mus musculus Rodents GPAT4 GPAT4 ncbigene_symbol Gpat4 102247
Mus musculus Rodents AGPAT1 AGPAT1 ncbigene_symbol Agpat1 55979
Mus musculus Rodents AGPAT2 AGPAT2 ncbigene_symbol Agpat2 67512
Mus musculus Rodents AGPAT3-5 AGPAT4 ncbigene_symbol Agpat4 68262
Mus musculus Rodents AGPAT3-5 AGPAT5 ncbigene_symbol Agpat5 52123
Mus musculus Rodents AGPAT3-5 AGPAT3 ncbigene_symbol Agpat3 28169
Mus musculus Rodents Lipin1 LIPIN1 ncbigene_synonym Lpin1 14245
Mus musculus Rodents PS PS ncbigene_symbol Ps 109641
Mus musculus Rodents PC, PC ncbigene_symbol pc 18517
Mus musculus Rodents DGAT1 DGAT1 ncbigene_symbol Dgat1 13350
Mus musculus Rodents DGAT2 DGAT2 ncbigene_symbol Dgat2 67800
Mus musculus Rodents TAG TAG ncbigene_symbol Tag 107423
Homo sapiens Primates GPAT1 GPAT1 ncbigene_synonym GPAM 57678
Homo sapiens Primates GPAT3 GPAT3 ncbigene_symbol GPAT3 84803
Homo sapiens Primates GPAT2 GPAT2 ncbigene_symbol GPAT2 150763
Homo sapiens Primates GPAT4 GPAT4 ncbigene_symbol GPAT4 137964
Homo sapiens Primates LPA LPA ncbigene_symbol LPA 4018
Homo sapiens Primates AGPAT1 AGPAT1 ncbigene_symbol AGPAT1 10554
Homo sapiens Primates AGPAT2 AGPAT2 ncbigene_symbol AGPAT2 10555
Homo sapiens Primates AGPAT3-5 AGPAT4 ncbigene_symbol AGPAT4 56895
Homo sapiens Primates AGPAT3-5 AGPAT5 ncbigene_symbol AGPAT5 55326
Homo sapiens Primates AGPAT3-5 AGPAT3 ncbigene_symbol AGPAT3 56894
Homo sapiens Primates PC, PC ncbigene_symbol PC 5091
Homo sapiens Primates PC,PE,PS PCPE ncbigene_synonym PCOLCE 5118
Homo sapiens Primates DGAT1 DGAT1 ncbigene_symbol DGAT1 8694
Homo sapiens Primates DGAT2 DGAT2 ncbigene_symbol DGAT2 84649
Homo sapiens Primates TAG TAG ncbigene_synonym TMED7 51014
Homo sapiens Primates TAG TAG ncbigene_synonym LINC01194 404663
Drosophila melanogaster Invertebrates GPAT1 GPAT1 ncbigene_synonym mino 43350
Drosophila melanogaster Invertebrates GPAT4 GPAT4 ncbigene_symbol Gpat4 37852
Drosophila melanogaster Invertebrates AGPAT1 AGPAT1 ncbigene_symbol Agpat1 32230
Drosophila melanogaster Invertebrates AGPAT1 AGPAT1 ncbigene_synonym Agpat2 34176
Drosophila melanogaster Invertebrates AGPAT3-5 AGPAT4 ncbigene_symbol Agpat4 39819
Drosophila melanogaster Invertebrates AGPAT3-5 AGPAT3 ncbigene_symbol Agpat3 39820
Drosophila melanogaster Invertebrates PA PA ncbigene_symbol Pa 251550
Drosophila melanogaster Invertebrates PI, PI ncbigene_symbol pi 5656965
Drosophila melanogaster Invertebrates PG, PG ncbigene_symbol pg 252323
Drosophila melanogaster Invertebrates CL CL ncbigene_symbol cl 43938
Drosophila melanogaster Invertebrates PS PS ncbigene_symbol ps 44258
Drosophila melanogaster Invertebrates PC, PC ncbigene_symbol Pc 40358
Drosophila melanogaster Invertebrates PE, PE ncbigene_symbol pe 252319
Drosophila melanogaster Invertebrates DGAT1 DGAT1 ncbigene_synonym mdy 44887
Drosophila melanogaster Invertebrates DGAT2 DGAT2 ncbigene_symbol Dgat2 35719

Chemical mentions

Word Match MeSH Name ChEBI
Glycerol-3-phosphate NA mesh:C029620
Acyl-CoA NA mesh:D000214

Disease mentions

Word Match MeSH Name DOID