Antigrowth signaling pathway and cluster around SMAD proteins

Antigrowth signaling pathway and cluster around SMAD proteins. (a) Antigrowth signaling pathway. Nodes and edges represent human proteins and protein-protein interactions, respectively. Edges with direction represent a regulatory relation. → means an activating relation and, ⊣ means an inhibitory relation. (b) Cluster around smads. Red edges represent differentially changed relations. Blue edges represent unchanged relations. Red nodes represent tumor suppressor genes, and green nodes represent oncogenes.
Antigrowth signaling pathway and cluster around SMAD proteins
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Publication

Integrating Multiple Microarray Data for Cancer Pathway Analysis Using Bootstrapping K-S Test. (2009) Bing Han, et al. J Biomed Biotechnol. 2009;2009:707580. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates Tgfbeta TGFBETA ncbigene_synonym TGFB1 7040
Homo sapiens Primates TgfbetaRI TGFBR1 ncbigene_symbol TGFBR1 7046
Homo sapiens Primates TgfbetaR2 TGFBR2 ncbigene_symbol TGFBR2 7048
Homo sapiens Primates pl6 PL6 ncbigene_synonym TMEM115 11070
Homo sapiens Primates pl6 P16 ncbigene_synonym CDKN2A 1029
Homo sapiens Primates pl6 P16 ncbigene_synonym H3P10 115482713
Homo sapiens Primates pl6 PI6 ncbigene_synonym SERPINB6 5269
Homo sapiens Primates MDM2 MDM2 ncbigene_symbol MDM2 4193
Homo sapiens Primates Smad3 SMAD3 ncbigene_symbol SMAD3 4088
Homo sapiens Primates Smad2 SMAD2 ncbigene_symbol SMAD2 4087
Homo sapiens Primates Smad4 SMAD4 ncbigene_symbol SMAD4 4089
Homo sapiens Primates p21 P21 ncbigene_synonym CDKN1A 1026
Homo sapiens Primates p21 P21 ncbigene_synonym TCEAL1 9338
Homo sapiens Primates p21 P21 ncbigene_synonym NSG1 27065
Homo sapiens Primates p21 P21 ncbigene_synonym H3P16 644914
Homo sapiens Primates p15 P15 ncbigene_synonym CDKN2B 1030
Homo sapiens Primates p15 P15 ncbigene_synonym MRPL28 10573
Homo sapiens Primates p15 P15 ncbigene_synonym SUB1 10923
Homo sapiens Primates p15 P15 ncbigene_synonym NXT1 29107
Homo sapiens Primates p15 P15 ncbigene_synonym H3P9 115482684
Homo sapiens Primates CyclinD CYCLIND famplex_relations CCND1 595
Homo sapiens Primates CyclinD CYCLIND famplex_relations CCND2 894
Homo sapiens Primates CyclinD CYCLIND famplex_relations CCND3 896
Homo sapiens Primates CyclinE CYCLINE famplex_relations CCNE1 898
Homo sapiens Primates CyclinE CYCLINE famplex_relations CCNE2 9134
Homo sapiens Primates CDK2 CDK2 ncbigene_symbol CDK2 1017
Homo sapiens Primates CDK6 CDK6 ncbigene_symbol CDK6 1021
Homo sapiens Primates CDK4 CDK4 ncbigene_symbol CDK4 1019
Homo sapiens Primates E2F E2F famplex_relations E2F1 1869
Homo sapiens Primates E2F E2F famplex_relations E2F2 1870
Homo sapiens Primates E2F E2F famplex_relations E2F3 1871
Homo sapiens Primates E2F E2F famplex_relations E2F4 1874
Homo sapiens Primates E2F E2F famplex_relations E2F5 1875
Homo sapiens Primates E2F E2F famplex_relations E2F6 1876
Homo sapiens Primates E2F E2F famplex_relations E2F7 144455
Homo sapiens Primates E2F E2F famplex_relations E2F8 79733
Homo sapiens Primates CDC2 CDC2 ncbigene_synonym CDK1 983
Homo sapiens Primates CDC2 CDC2 ncbigene_synonym POLD1 5424
Homo sapiens Primates MYC MYC ncbigene_symbol MYC 4609
Homo sapiens Primates SMAD9 SMAD9 ncbigene_symbol SMAD9 4093
Homo sapiens Primates RHOD RHOD ncbigene_symbol RHOD 29984
Homo sapiens Primates HNF4A HNF4A ncbigene_symbol HNF4A 3172
Homo sapiens Primates HNF4A HNF4A ncbigene_synonym HNF1A 6927
Homo sapiens Primates PAPOLA PAPOLA ncbigene_symbol PAPOLA 10914
Homo sapiens Primates MAGI2 MAGI2 ncbigene_symbol MAGI2 9863
Homo sapiens Primates SF3B2 SF3B2 ncbigene_symbol SF3B2 10992
Homo sapiens Primates FBLN1 FBLN1 ncbigene_symbol FBLN1 2192
Homo sapiens Primates PSMD11 PSMD11 ncbigene_symbol PSMD11 5717
Homo sapiens Primates SNRP70 SNRP70 ncbigene_synonym SNRNP70 6625
Homo sapiens Primates GPNMB GPNMB ncbigene_symbol GPNMB 10457

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID