Diagrammatic representation of the signalling pathways activated in the unfolded protein response following ER stress

Diagrammatic representation of the signalling pathways activated in the unfolded protein response following ER stress. The sensor molecules, PKR-like endoplasmic reticulum kinase (PERK), inositol-requiring 1 (Ire1) and activating transcription factor 6 (ATF6), are transmembrane proteins normally held inactive by the binding of GRP78/BiP, but are released when the GRP78 preferentially binds to misfolded proteins accumulating in the ER lumen. The UPR aims to restore homeostasis within the ER, but there are also links to the inflammatory response through the Ire1 pathway and TNF receptor-associated factor 2 (TRAF2).
Diagrammatic representation of the signalling pathways activated in the unfolded protein response following ER stress
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Publication

Placental Endoplasmic Reticulum Stress and Oxidative Stress in the Pathophysiology of Unexplained Intrauterine Growth Restriction and Early Onset Preeclampsia. (2009) G.J. Burton, et al. Placenta. 2009 Mar;30(Suppl):43-48. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Caenorhabditis elegans Invertebrates ATF6 ATF6 ncbigene_symbol atf-6 181405
Caenorhabditis elegans Invertebrates Ire1 IRE1 ncbigene_symbol ire-1 174305
Caenorhabditis elegans Invertebrates p-elF2a EIF2A ncbigene_symbol eif-2alpha 171769
Caenorhabditis elegans Invertebrates p-elF2a EIF2A ncbigene_symbol eif-2A 174606
Caenorhabditis elegans Invertebrates XBP-1 XBP-1 ncbigene_symbol xbp-1 175541
Homo sapiens Primates GRP78 GRP78 ncbigene_synonym HSPA5 3309
Homo sapiens Primates GRP78/BIP BIP ncbigene_synonym GDF10 2662
Homo sapiens Primates TF TF ncbigene_symbol TF 7018
Homo sapiens Primates PERK PERK ncbigene_synonym EIF2AK3 9451
Homo sapiens Primates ATF6 ATF6 ncbigene_symbol ATF6 22926
Homo sapiens Primates Ire1 IRE1 ncbigene_synonym ERN1 2081
Homo sapiens Primates TRAF2 TRAF2 ncbigene_symbol TRAF2 7186
Homo sapiens Primates TRAF2 TRAF2 ncbigene_synonym TANK 10010
Homo sapiens Primates p-elF2a EIF2A ncbigene_symbol EIF2A 83939
Homo sapiens Primates p-elF2a EIF2A ncbigene_synonym EIF2S1 1965
Homo sapiens Primates XBP-1 XBP-1 ncbigene_synonym XBP1 7494
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates CHOP CHOP ncbigene_synonym DDIT3 1649

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID