Thymidine biosynthetic pathway

Thymidine biosynthetic pathway. The steps engineered in this study are indicated by the bold arrows and lines. Components of the catabolism are as follows: pyrA, carbamoylphosphate synthase; pyrBI, aspartate-carbamoyl transferase; pyrC, dihydroorotase; pyrD, dihydroorotate oxidase; pyrE, orotate phosphoribosyltransferase; pyrF, OMP decarboxylase; pyrG, CTP synthetase; pyrH, UMP kinase; TMPase, TMP phosphohydrolase; nrd, nucleotide diphosphate reductase; tdΔI, T4 thymidylate synthase (intron deleted); thyA, thymidylate synthase; dcd, dCTP deaminase; udk, uridine kinase; deoA, thymidine phosphorylase; tdk, thymidine kinase; udp, uridine phosphorylase; dut, deoxyribonucleotide triphosphatase; ndk, nucleotide diphosphate kinase; tmk, TMP kinase; ung, uracil-DNA N-glycosylase; upp, uracil phosphoribosyl-transferase; cdd, cytidine deaminase; codA, cytosine deaminase.
Thymidine biosynthetic pathway
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Publication

Fermentative Production of Thymidine by a Metabolically Engineered Escherichia coli Strain . (2009) Hyeon Cheol Lee, et al. Appl Environ Microbiol. 2009 Apr;75(8):2423-2432. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Escherichia coli str. K-12 substr. MG1655 Bacteria pyrb PYRB ncbigene_symbol pyrB 948767
Escherichia coli str. K-12 substr. MG1655 Bacteria PyrA PYRA ncbigene_synonym carB 944775
Escherichia coli str. K-12 substr. MG1655 Bacteria PyrA PYRA ncbigene_synonym carA 949025
Escherichia coli str. K-12 substr. MG1655 Bacteria pyrc PYRC ncbigene_symbol pyrC 945787
Escherichia coli str. K-12 substr. MG1655 Bacteria pyrE PYRE ncbigene_symbol pyrE 948157
Escherichia coli str. K-12 substr. MG1655 Bacteria pyrE PYRE ncbigene_synonym pyrL 948768
Escherichia coli str. K-12 substr. MG1655 Bacteria |pyrF PYRF ncbigene_symbol pyrF 947121
Escherichia coli str. K-12 substr. MG1655 Bacteria UDP UDP ncbigene_symbol udp 948987
Escherichia coli str. K-12 substr. MG1655 Bacteria tmk TMK ncbigene_symbol tmk 945663
Escherichia coli str. K-12 substr. MG1655 Bacteria dut DUT ncbigene_symbol dut 948607
Escherichia coli str. K-12 substr. MG1655 Bacteria ndk NDK ncbigene_symbol ndk 945611
Escherichia coli str. K-12 substr. MG1655 Bacteria pyrH PYRH ncbigene_symbol pyrH 944989
Escherichia coli str. K-12 substr. MG1655 Bacteria thyA THYA ncbigene_symbol thyA 949035
Escherichia coli str. K-12 substr. MG1655 Bacteria (ung) UNG ncbigene_symbol ung 947067
Escherichia coli str. K-12 substr. MG1655 Bacteria tdk TDK ncbigene_symbol tdk 945834
Escherichia coli str. K-12 substr. MG1655 Bacteria pyrG PYRG ncbigene_symbol pyrG 946116
Escherichia coli str. K-12 substr. MG1655 Bacteria udk UDK ncbigene_symbol udk 946597
Escherichia coli str. K-12 substr. MG1655 Bacteria upp UPP ncbigene_symbol upp 946979
Escherichia coli str. K-12 substr. MG1655 Bacteria deoA DEOA ncbigene_symbol deoA 948901
Escherichia coli str. K-12 substr. MG1655 Bacteria cdd CDD ncbigene_symbol cdd 946663
Escherichia coli str. K-12 substr. MG1655 Bacteria codA CODA ncbigene_symbol codA 944996

Chemical mentions

Word Match MeSH Name ChEBI
ATMP NA mesh:C034220
ACDP ODP NA mesh:C067723
Asp NA mesh:D001224
Cytidine Cytidine mesh:D003562 cytidine chebi:17562
CMP Cytidine Monophosphate mesh:D003568 cytidine 5'-monophosphate chebi:17361
Cytosine Cytosine mesh:D003596 cytosine chebi:16040
phosphate NA mesh:D010710
Thymidine Deoxyuridine Thymidine mesh:D013936 thymidine chebi:17748
Thymine Thymine mesh:D013941 thymine chebi:17821
Uracil Uracil mesh:D014498 uracil chebi:17568
Uridine Uridine mesh:D014529 uridine chebi:16704
UDP Uridine Diphosphate mesh:D014530 UDP chebi:17659
UMP Uridine Monophosphate mesh:D014542 uridine 5'-monophosphate chebi:16695
UTP Uridine Triphosphate mesh:D014544 UTP chebi:15713

Disease mentions

Word Match MeSH Name DOID