Hypoxia-invoked response of the glycolysis gene network

Hypoxia-invoked response of the glycolysis gene network. Expression of glycolysis-enhancing enzymes (masked with pale pink) was up-regulated while that of glycolysis-suppressing enzymes (masked with pale blue) was down-regulated. Human genes assigned to the glycolysis pathway map of the KEGG database were selected, and TSS-tag numbers of the corresponding genes were evaluated. Red bars and blue bars represent TSS-tag ppm in normoxia and hypoxia respectively. Fold induction for each of the genes is shown in Supplementary Table 11. Genes included in the list of the ‘hypoxia-induced’ 120 genes are highlighted by green boxes. Note that, since we used the stricter criteria for selecting hypoxia-induced genes (>10 p.p.m., >5-fold induction), many of the genes belonging to this pathway are not directly included in the list, though they showed inductions at least to some extent.

Publication

Massive transcriptional start site analysis of human genes in hypoxia cells. (2009) Katsuya Tsuchihara, et al. Nucleic Acids Res. 2009 Apr;37(7):2249-2263. Figure: F6. Homo sapiens

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