EGFR Signaling Pathway

The EGFR Signaling Pathway. (a) Upon EGF-ligand binding to the EGFR there is subsequent dimerization (homo- or hetero-) and tyrosine kinase residue auto-/transphosphorylation of dimer partners, which in turn initiates the actual downstream signaling pathways. (b) Ras signaling cascade in tabulated form. (c) PI3K signaling cascade in tabulated form.
EGFR Signaling Pathway
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Publication

Anti-EGFR Therapy: Mechanism and Advances in Clinical Efficacy in Breast Cancer. (2009) John F. Flynn, et al. J Oncol. 2009;2009:526963. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates (TK) TK ncbigene_symbol Tk 41456
Drosophila melanogaster Invertebrates and AND ncbigene_synonym CkIIbeta 32132
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Andorra 32798
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Anp 43595
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Acam 44913
Drosophila melanogaster Invertebrates Ras RAS ncbigene_symbol ras 43873
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras64B 38494
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates →GRB2 GRB2 ncbigene_synonym drk 36497
Drosophila melanogaster Invertebrates SOS SOS ncbigene_symbol Sos 34790
Drosophila melanogaster Invertebrates Raf RAF ncbigene_symbol Raf 31221
Drosophila melanogaster Invertebrates →MEK MEK ncbigene_synonym Dsor1 31872
Drosophila melanogaster Invertebrates →MEK MEK ncbigene_synonym Mtk 36708
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym MKP-4 32963
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym p38b 34780
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates Transcriptionfactorsinclude:c-Jun,JNK,p38,c-mycand JNK ncbigene_synonym bsk 44801
Drosophila melanogaster Invertebrates Transcriptionfactorsinclude:c-Jun,JNK,p38,c-mycand P38 ncbigene_synonym lic 32257
Drosophila melanogaster Invertebrates Transcriptionfactorsinclude:c-Jun,JNK,p38,c-mycand P38 ncbigene_synonym Nurf-38 37922
Drosophila melanogaster Invertebrates Transcriptionfactorsinclude:c-Jun,JNK,p38,c-mycand P38 ncbigene_synonym Ebp 38009
Drosophila melanogaster Invertebrates Transcriptionfactorsinclude:c-Jun,JNK,p38,c-mycand P38 ncbigene_synonym AIMP2 39690
Drosophila melanogaster Invertebrates Transcriptionfactorsinclude:c-Jun,JNK,p38,c-mycand P38 ncbigene_synonym p38a 42866
Drosophila melanogaster Invertebrates Transcriptionfactorsinclude:c-Jun,JNK,p38,c-mycand P38 ncbigene_synonym Hrb87F 48535
Drosophila melanogaster Invertebrates Transcriptionfactorsinclude:c-Jun,JNK,p38,c-mycand P38 ncbigene_synonym p38c 2768679
Drosophila melanogaster Invertebrates c-Jun, C-JUN ncbigene_synonym Jra 36057
Drosophila melanogaster Invertebrates c-myc C-MYC ncbigene_synonym Myc 31310
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym inaC 36897
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym Pkc98E 43428
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym aPKC 47594
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym Pkc53E 48311
Drosophila melanogaster Invertebrates EGFR EGFR ncbigene_symbol Egfr 37455
Drosophila melanogaster Invertebrates cycle; CYCLE ncbigene_synonym CycE 34924
Drosophila melanogaster Invertebrates cycle; CYCLE ncbigene_synonym cyc 40162
Drosophila melanogaster Invertebrates IKK IKK ncbigene_synonym IKKepsilon 35329
Drosophila melanogaster Invertebrates IKK IKK ncbigene_synonym key 37967
Drosophila melanogaster Invertebrates IKK IKK ncbigene_synonym IKKbeta 44432
Drosophila melanogaster Invertebrates NFKB NFKB ncbigene_synonym Dif 35045
Drosophila melanogaster Invertebrates NFKB NFKB ncbigene_synonym dl 35047
Drosophila melanogaster Invertebrates NFKB NFKB ncbigene_synonym Rel 41087
Drosophila melanogaster Invertebrates CDK4 CDK4 ncbigene_symbol Cdk4 36854
Drosophila melanogaster Invertebrates an AN ncbigene_symbol an 247752
Drosophila melanogaster Invertebrates act ACT ncbigene_symbol act 5656844
Drosophila melanogaster Invertebrates act ACT ncbigene_synonym Act5C 31521
Drosophila melanogaster Invertebrates act ACT ncbigene_synonym NA 32640
Drosophila melanogaster Invertebrates act ACT ncbigene_synonym Act42A 35526
Drosophila melanogaster Invertebrates act ACT ncbigene_synonym Actbeta 43826
Drosophila melanogaster Invertebrates is IS ncbigene_symbol Is 44518
Drosophila melanogaster Invertebrates RB RB ncbigene_symbol rb 31381
Drosophila melanogaster Invertebrates E2F+ E2F ncbigene_synonym ebi 33212
Drosophila melanogaster Invertebrates E2F+ E2F ncbigene_synonym E2f2 35381
Drosophila melanogaster Invertebrates E2F+ E2F ncbigene_synonym E2f1 42550
Drosophila melanogaster Invertebrates ST ST ncbigene_symbol st 39836
Homo sapiens Primates HER-2 HER-2 ncbigene_synonym ERBB2 2064
Homo sapiens Primates (TK) TK famplex_relations TK1 7083
Homo sapiens Primates (TK) TK famplex_relations TK2 7084
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates →GRB2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates ErbB1 ERBB1 ncbigene_synonym EGFR 1956
Homo sapiens Primates SOS SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates SOS SOS famplex_relations SOS1 6654
Homo sapiens Primates SOS SOS famplex_relations SOS2 6655
Homo sapiens Primates Raf RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates Raf RAF famplex_relations ARAF 369
Homo sapiens Primates Raf RAF famplex_relations BRAF 673
Homo sapiens Primates Raf RAF famplex_relations RAF1 5894
Homo sapiens Primates →MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates →MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates →MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates Transcriptionfactorsinclude:c-Jun,JNK,p38,c-mycand P38 ncbigene_synonym CRK 1398
Homo sapiens Primates Transcriptionfactorsinclude:c-Jun,JNK,p38,c-mycand P38 ncbigene_synonym AIMP2 7965
Homo sapiens Primates Transcriptionfactorsinclude:c-Jun,JNK,p38,c-mycand P38 ncbigene_synonym GRAP2 9402
Homo sapiens Primates Transcriptionfactorsinclude:c-Jun,JNK,p38,c-mycand P38 ncbigene_synonym AHSA1 10598
Homo sapiens Primates Transcriptionfactorsinclude:c-Jun,JNK,p38,c-mycand P38 ncbigene_synonym POLDIP2 26073
Homo sapiens Primates c-Jun, C-JUN ncbigene_synonym JUN 3725
Homo sapiens Primates c-myc C-MYC ncbigene_synonym MYC 4609
Homo sapiens Primates PKC PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKC PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKC PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKC PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKC PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKC PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKC PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKC PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKC PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKC PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKC PKC famplex_relations PRKD3 23683
Homo sapiens Primates IKK IKK famplex_relations CHUK 1147
Homo sapiens Primates IKK IKK famplex_relations IKBKB 3551
Homo sapiens Primates IKK IKK famplex_relations IKBKG 8517
Homo sapiens Primates IKK IKK famplex_relations IKBKE 9641
Homo sapiens Primates IKK IKK famplex_relations TBK1 29110
Homo sapiens Primates NFKB NFKB ncbigene_synonym NFKB1 4790
Homo sapiens Primates NFKB NFKB famplex_relations RELA 5970
Homo sapiens Primates NFKB NFKB famplex_relations RELB 5971
Homo sapiens Primates NFKB NFKB famplex_relations REL 5966
Homo sapiens Primates NFKB NFKB famplex_relations NFKB2 4791
Homo sapiens Primates CyclinD1 CCND1 ncbigene_symbol CCND1 595
Homo sapiens Primates CDK4 CDK4 ncbigene_symbol CDK4 1019
Homo sapiens Primates an AN ncbigene_symbol AN 100187761
Homo sapiens Primates CDK4/6 CDK6 ncbigene_symbol CDK6 1021
Homo sapiens Primates Gj, GJ famplex_relations GJA1 2697
Homo sapiens Primates Gj, GJ famplex_relations GJA10 84694
Homo sapiens Primates Gj, GJ famplex_relations GJA3 2700
Homo sapiens Primates Gj, GJ famplex_relations GJA4 2701
Homo sapiens Primates Gj, GJ famplex_relations GJA5 2702
Homo sapiens Primates Gj, GJ famplex_relations GJA8 2703
Homo sapiens Primates Gj, GJ famplex_relations GJA9 81025
Homo sapiens Primates Gj, GJ famplex_relations GJB1 2705
Homo sapiens Primates Gj, GJ famplex_relations GJB2 2706
Homo sapiens Primates Gj, GJ famplex_relations GJB3 2707
Homo sapiens Primates Gj, GJ famplex_relations GJB4 127534
Homo sapiens Primates Gj, GJ famplex_relations GJB5 2709
Homo sapiens Primates Gj, GJ famplex_relations GJB6 10804
Homo sapiens Primates Gj, GJ famplex_relations GJB7 375519
Homo sapiens Primates Gj, GJ famplex_relations GJC1 10052
Homo sapiens Primates Gj, GJ famplex_relations GJC2 57165
Homo sapiens Primates Gj, GJ famplex_relations GJC3 349149
Homo sapiens Primates Gj, GJ famplex_relations GJD2 57369
Homo sapiens Primates Gj, GJ famplex_relations GJD3 125111
Homo sapiens Primates Gj, GJ famplex_relations GJD4 219770
Homo sapiens Primates Gj, GJ famplex_relations GJE1 100126572
Homo sapiens Primates act ACT ncbigene_synonym SERPINA3 12
Homo sapiens Primates act ACT ncbigene_synonym ACTG1 71
Homo sapiens Primates act ACT ncbigene_synonym ACTG2 72
Homo sapiens Primates act ACT ncbigene_synonym FHL5 9457
Homo sapiens Primates act ACT ncbigene_synonym ACOT7 11332
Homo sapiens Primates act ACT ncbigene_synonym ACTBL2 345651
Homo sapiens Primates act ACT ncbigene_synonym POTEKP 440915
Homo sapiens Primates act ACT ncbigene_synonym POTEM 641455
Homo sapiens Primates E2F+ E2F famplex_relations E2F1 1869
Homo sapiens Primates E2F+ E2F famplex_relations E2F2 1870
Homo sapiens Primates E2F+ E2F famplex_relations E2F3 1871
Homo sapiens Primates E2F+ E2F famplex_relations E2F4 1874
Homo sapiens Primates E2F+ E2F famplex_relations E2F5 1875
Homo sapiens Primates E2F+ E2F famplex_relations E2F6 1876
Homo sapiens Primates E2F+ E2F famplex_relations E2F7 144455
Homo sapiens Primates E2F+ E2F famplex_relations E2F8 79733

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Cardiomyopathy NA
Lung cancer NA
Noonan syndrome NA