Simplified schematic diagram of transforming growth factor-alpha/epidermal growth factor receptor signaling pathway (TGFA/EGFR)

Simplified schematic diagram of transforming growth factor-alpha/epidermal growth factor receptor signaling pathway (TGF-α/EGFR). TGF-α binding to EGFR results in stimulation of the endogenous receptor tyrosine kinase (RTK). The activated membrane-bound EGFR serves as a docking site for recruitment of proteins such as Src homology 2 domain containing (Shc) and growth factor receptor-bound protein2 (Grb2). The signal then activates one of several intracellular signal transduction pathways including protein kinase A (PKA), mitogen-activated protein kinase (MAPK), Jak/Stat, and C-src pathways, which play important roles in cell proliferation. New therapeutic agents such as erlotinib, cetuximab, and lapatinib aim to block this signaling cascade.

Publication

Liver Stem Cells and Molecular Signaling Pathways in Hepatocellular Carcinoma. (2007) Krit Kitisin, et al. Gastrointest Cancer Res. 2007 Jul-Aug;1(4 Suppl 2):S13-S21. Figure: F6. All organisms Drosophila melanogaster Homo sapiens

Disease mentions