Reactions and proteins of the mitochondrial FAS pathway

Reactions and proteins of the mitochondrial FAS pathway. A, individual reactions of the FAS II pathway. As discussed in text, it remains to be experimentally demonstrated that generation of acyl-ACP exceeds a chain length of C8in vivo and that longer fatty acids have a role in mitochondrial physiology. B, protein components of the mitochondrial FAS pathway and the corresponding genes in yeast and humans. All proteins of the mitochondrial FAS pathway required to synthesize saturated fatty acids have been identified and at least partially characterized in bakers' yeast. The enzymes responsible for carboxylation of acetyl-CoA and the 3-ketoacyl-ACP reduction reaction in humans have not yet been determined.
Reactions and proteins of the mitochondrial FAS pathway
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Publication

Mitochondrial Fatty Acid Synthesis Type II: More than Just Fatty Acids. (2009) J. Kalervo Hiltunen, et al. J Biol Chem. 2009 Apr 3;284(14):9011-9015. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates ATP ATP ncbigene_synonym ATP8A2 51761
Homo sapiens Primates Acyl ACY1 ncbigene_symbol ACY1 95
Homo sapiens Primates PPT2 PPT2 ncbigene_symbol PPT2 9374
Homo sapiens Primates PPT2 PPT2 ncbigene_synonym PPT2-EGFL8 100532746
Homo sapiens Primates AASDHPPT? AASDHPPT ncbigene_symbol AASDHPPT 60496
Homo sapiens Primates ACP ACP ncbigene_synonym NDUFAB1 4706
Homo sapiens Primates ACP ACP ncbigene_synonym CPAT1 60502
Homo sapiens Primates MCAT MCAT ncbigene_symbol MCAT 27349
Homo sapiens Primates OXSM OXSM ncbigene_symbol OXSM 54995
Homo sapiens Primates RPP14/HSHTD2 RPP14 ncbigene_symbol RPP14 11102
Homo sapiens Primates HTD2 HTD2 ncbigene_symbol HTD2 109703458
Homo sapiens Primates NADPH NADPH ncbigene_synonym DECR1 1666
Homo sapiens Primates MECR MECR ncbigene_symbol MECR 51102
Danio rerio Vertebrates Acyl ACY1 ncbigene_symbol acy1 393970
Danio rerio Vertebrates PPT2 PPT2 ncbigene_synonym ppt2b 100126133
Danio rerio Vertebrates AASDHPPT? AASDHPPT ncbigene_symbol aasdhppt 619247
Danio rerio Vertebrates CoA COA ncbigene_synonym napbb 568195
Danio rerio Vertebrates MCAT MCAT ncbigene_symbol mcat 564111
Danio rerio Vertebrates OXSM OXSM ncbigene_symbol oxsm 564649
Danio rerio Vertebrates RPP14/HSHTD2 RPP14 ncbigene_symbol rpp14 553721
Danio rerio Vertebrates MECR MECR ncbigene_symbol mecr 550550

Chemical mentions

Word Match MeSH Name ChEBI
Phosphopantetheine D-pantetheine 4'-phosphate mesh:C003129 4'-phosphopantetheine chebi:4222
Acyl-ACP L-2-amino-4-chloropent-4-enoic acid mesh:C053078 2-amino-4-chloro-4-pentenoic acid chebi:15885
Malonyl-CoA Malonyl Coenzyme A mesh:D008316 malonyl-CoA chebi:15531

Disease mentions

Word Match MeSH Name DOID