The TSC-mTOR signaling

A model of the TSC-mTOR signaling. Phosphorylation-dependent signaling cascades of the TSC-mTOR pathway are depicted. The kinases and their target phosphorylation are denoted with the same color.
The TSC-mTOR signaling
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Publication

Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment. (2009) Ken Inoki, et al. Hum Mol Genet. 2009 Apr 15;18(R1):R94-R100. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates PTEN PTEN ncbigene_symbol Pten 43991
Drosophila melanogaster Invertebrates PDK1 PDK1 ncbigene_symbol Pdk1 38017
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym Erk7 31877
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates LKB1 LKB1 ncbigene_symbol Lkb1 41673
Drosophila melanogaster Invertebrates AMPK AMPK ncbigene_synonym SNF4Agamma 42515
Drosophila melanogaster Invertebrates AMPK AMPK ncbigene_synonym AMPKalpha 43904
Drosophila melanogaster Invertebrates TSC2 TSC2 ncbigene_synonym gig 40201
Drosophila melanogaster Invertebrates TSC1 TSC1 ncbigene_symbol Tsc1 42862
Drosophila melanogaster Invertebrates IKK IKK ncbigene_synonym IKKepsilon 35329
Drosophila melanogaster Invertebrates IKK IKK ncbigene_synonym key 37967
Drosophila melanogaster Invertebrates IKK IKK ncbigene_synonym IKKbeta 44432
Drosophila melanogaster Invertebrates GSK3 GSK3 ncbigene_synonym sgg 31248
Drosophila melanogaster Invertebrates Rheb RHEB ncbigene_symbol Rheb 117332
Drosophila melanogaster Invertebrates PRAS40 PRAS40 ncbigene_symbol PRAS40 26067067
Drosophila melanogaster Invertebrates MTORC1 MTORC1 ncbigene_synonym Crtc 39970
Drosophila melanogaster Invertebrates RagA RAGA ncbigene_synonym RagA-B 41071
Drosophila melanogaster Invertebrates RagC/D RAGC ncbigene_synonym RagC-D 35793
Drosophila melanogaster Invertebrates 4EBP1 4EBP1 ncbigene_synonym Thor 33569
Drosophila melanogaster Invertebrates S6K S6K ncbigene_symbol S6k 38654
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations ANGPT1 284
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations ANGPT2 285
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations ANGPT4 51378
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations AREG 374
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations BDNF 627
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations CSF1 1435
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EFNA1 1942
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EFNA2 1943
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EFNA3 1944
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EFNA4 1945
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EFNA5 1946
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EGF 1950
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EREG 2069
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF1 2246
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF10 2255
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF16 8823
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF17 8822
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF18 8817
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF19 9965
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF2 2247
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF20 26281
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF21 26291
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF22 27006
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF23 8074
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF3 2248
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF4 2249
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF5 2250
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF6 2251
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF7 2252
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF8 2253
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF9 2254
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FLT3LG 2323
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations HGF 3082
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations IGF1 3479
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations IGF2 3481
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations INS 3630
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations KITLG 4254
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations NGF 4803
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations NTF3 4908
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations NTF4 4909
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations PDGFA 5154
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations PDGFB 5155
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations PDGFC 56034
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations PDGFD 80310
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations PGF 5228
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations TGFA 7039
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations VEGFA 7422
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations VEGFB 7423
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations VEGFC 7424
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations VEGFD 2277
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates MTORC2 MTORC2 famplex_relations MAPKAP1 79109
Homo sapiens Primates MTORC2 MTORC2 famplex_relations MTOR 2475
Homo sapiens Primates MTORC2 MTORC2 famplex_relations RICTOR 253260
Homo sapiens Primates MTORC2 MTORC2 famplex_relations MLST8 64223
Homo sapiens Primates PDK1 PDK1 ncbigene_symbol PDK1 5163
Homo sapiens Primates PDK1 PDK1 ncbigene_synonym PDPK1 5170
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates SGK1 SGK1 ncbigene_symbol SGK1 6446
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates LKB1 LKB1 ncbigene_synonym STK11 6794
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA1 5562
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA2 5563
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAB1 5564
Homo sapiens Primates AMPK AMPK famplex_relations PRKAB2 5565
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG1 5571
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG2 51422
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG3 53632
Homo sapiens Primates TSC2 TSC2 ncbigene_symbol TSC2 7249
Homo sapiens Primates TSC1 TSC1 ncbigene_symbol TSC1 7248
Homo sapiens Primates TSC1 TSC1 ncbigene_synonym CCL26 10344
Homo sapiens Primates IKK IKK famplex_relations CHUK 1147
Homo sapiens Primates IKK IKK famplex_relations IKBKB 3551
Homo sapiens Primates IKK IKK famplex_relations IKBKG 8517
Homo sapiens Primates IKK IKK famplex_relations IKBKE 9641
Homo sapiens Primates IKK IKK famplex_relations TBK1 29110
Homo sapiens Primates GSK3 GSK3 famplex_relations GSK3A 2931
Homo sapiens Primates GSK3 GSK3 famplex_relations GSK3B 2932
Homo sapiens Primates GTP GTP ncbigene_synonym MTG1 92170
Homo sapiens Primates Rheb RHEB ncbigene_symbol RHEB 6009
Homo sapiens Primates Rheb RHEB ncbigene_synonym RHEBP1 6008
Homo sapiens Primates PRAS40 PRAS40 ncbigene_synonym AKT1S1 84335
Homo sapiens Primates MTORC1 MTORC1 famplex_relations RPTOR 57521
Homo sapiens Primates RagA RAGA ncbigene_synonym RRAGA 10670
Homo sapiens Primates RagA/B RAGB ncbigene_synonym RRAGB 10325
Homo sapiens Primates RagC/D RAGD ncbigene_synonym RRAGD 58528
Homo sapiens Primates RagC/D RAGC ncbigene_synonym RRAGC 64121
Homo sapiens Primates 4EBP1 4EBP1 ncbigene_synonym EIF4EBP1 1978
Homo sapiens Primates S6K S6K ncbigene_synonym RPS6KB1 6198

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID