De novo purine biosynthesis pathway

The de novo purine biosynthesis pathway. Enzymes associated with pathology are underlined. The steps encoded by the GART gene are indicated. Abbreviations are: R-5-P, ribose-5-phosphate; PRPP, phosphoribosylpyrophosphate; PRA, phosphoribosylamine; GAR, phosphoribosylglycinamide; FGAR, phosphoribosylformylglycinamide; FGAM, phosphoribosylformylglycineamidine; AIR, phosphoribosylaminoimidazole; CAIR, phosphoribosylaminoimidazole- carboxylate; SAICAR, phosphoribosylsuccinylaminoimidazole; AICAR, phosphoribosylaminoimidazolecarboaxamide; FAICAR, phosphoribosylformylaminoimidazolecarboxamide; IMP, inosine monophosphate; SAMP, adenylosuccinate; XMP, xanthosine monophosphate; AMP, adenosine monophosphate; GMP, guanosine monophosphate. Pathway enzymes are: (1) PRAT, phosphoribosylamidotransferase; (2) GARS, GAR synthetase; (3) GART, GAR transformylase; (4) FGARAT, FGAR amidotransferase; (5) AIRS, AIR synthetase; (6) AIRC, AIR carboxylase; (7) SAICARS, SAICAR synthetase; (8) and (12) ADSL, adenylosuccinate lyase; (9) AICART, AICAR transformylase; (10) IMPS, IMP synthetase; SAMPS, SAMP synthetase; IMPDH, IMP dehydrogenase; GMPS, GMP synthetase. PRPS1, phosphoribosylpyrophosphate synthase 1

Publication

Mutations in the Chinese hamster ovary cell GART gene of de novo purine synthesis. () Aaron J. Knox, et al. Gene. ;429(1-2):23-30. Figure: F1. All organisms Drosophila melanogaster Homo sapiens

Disease mentions