EGFR signaling pathways

EGFR signaling pathways. Two important cell-survival pathways that operate downstream of activated ErbB transmembrane receptor tyrosine kinases (represented by pairs of yellow, and yellow and blue receptors to represent homo- and hetero-dimers, respectively), along with some of the key constituent signaling molecules are shown. The Ras-Raf-MEK-ERK pathway is shown on the left, and the phosphatidylinositol 3-kinase (PI3K)-AKT pathway is shown on the right. Key points along the pathway where targeted inhibition seems to exert a blockade are indicated by red circles, showing the relevant proteins they target. ERK, extracellular signal-regulated kinase; GRB2, growth factor receptor-bound protein 2; mTOR, mammalian target of rapamycin; SOS, son of sevenless. Used with permission from: Nature Reviews 2007 Sharma et al. Pg 177.
EGFR signaling pathways
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Publication

Recent advances of novel targeted therapy in non-small cell lung cancer. (2009) Jed A Katzel, et al. J Hematol Oncol. 2009;2:2-2. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents ErbB ERBB ncbigene_synonym Egfr 13649
Mus musculus Rodents p85 P85 ncbigene_synonym Ecm1 13601
Mus musculus Rodents p85 P85 ncbigene_synonym Ppp1r13b 21981
Mus musculus Rodents AKT AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents GRB2 GRB2 ncbigene_symbol Grb2 14784
Mus musculus Rodents RAS RAS ncbigene_symbol ras 19412
Mus musculus Rodents RAS RAS ncbigene_synonym Hras 15461
Mus musculus Rodents RAS RAS ncbigene_synonym Kras 16653
Mus musculus Rodents RAS RAS ncbigene_synonym Rem1 19700
Mus musculus Rodents GAP GAP ncbigene_synonym Rap1gap 110351
Mus musculus Rodents GAP GAP ncbigene_synonym Rasa1 218397
Mus musculus Rodents p10 P10 ncbigene_synonym S100a10 20194
Mus musculus Rodents RAF RAF ncbigene_synonym Zhx2 387609
Mus musculus Rodents SHIP SHIP ncbigene_synonym Inpp5d 16331
Mus musculus Rodents PTEN PTEN ncbigene_symbol Pten 19211
Mus musculus Rodents TSC2 TSC2 ncbigene_symbol Tsc2 22084
Mus musculus Rodents MEK MEK ncbigene_synonym Mdk 17242
Mus musculus Rodents (MTOR MTOR ncbigene_symbol Mtor 56717
Mus musculus Rodents ERK ERK ncbigene_synonym Ephb2 13844
Mus musculus Rodents ERK ERK ncbigene_synonym Mapk1 26413
Mus musculus Rodents PHLPP PHLPP ncbigene_synonym Phlpp1 98432
Homo sapiens Primates ErbB ERBB ncbigene_synonym EGFR 1956
Homo sapiens Primates ErbB ERBB famplex_relations ERBB2 2064
Homo sapiens Primates ErbB ERBB famplex_relations ERBB3 2065
Homo sapiens Primates ErbB ERBB famplex_relations ERBB4 2066
Homo sapiens Primates p85 P85 ncbigene_synonym PIK3R1 5295
Homo sapiens Primates p85 P85 ncbigene_synonym PIK3R2 5296
Homo sapiens Primates p85 P85 ncbigene_synonym ARHGEF7 8874
Homo sapiens Primates p85 P85 ncbigene_synonym CBFA2T2 9139
Homo sapiens Primates p85 P85 ncbigene_synonym PPP1R13B 23368
Homo sapiens Primates p85 P85 ncbigene_synonym PPP1R12C 54776
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates GRB2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates RAS RAS famplex_relations KRAS 3845
Homo sapiens Primates RAS RAS famplex_relations HRAS 3265
Homo sapiens Primates RAS RAS famplex_relations NRAS 4893
Homo sapiens Primates SOS SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates SOS SOS famplex_relations SOS1 6654
Homo sapiens Primates SOS SOS famplex_relations SOS2 6655
Homo sapiens Primates GAP GAP ncbigene_synonym RASA1 5921
Homo sapiens Primates GAP GAP ncbigene_synonym RGS6 9628
Homo sapiens Primates p10 P10 ncbigene_synonym S100A10 6281
Homo sapiens Primates p10 P10 ncbigene_synonym EXOSC3 51010
Homo sapiens Primates GTP GTP ncbigene_synonym MTG1 92170
Homo sapiens Primates RAF RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates RAF RAF famplex_relations ARAF 369
Homo sapiens Primates RAF RAF famplex_relations BRAF 673
Homo sapiens Primates RAF RAF famplex_relations RAF1 5894
Homo sapiens Primates SHIP SHIP ncbigene_synonym INPP5D 3635
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates TSC2 TSC2 ncbigene_symbol TSC2 7249
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates (MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates PHLPP PHLPP ncbigene_synonym PHLPP1 23239
Drosophila melanogaster Invertebrates p85 P85 ncbigene_synonym Myb 32543
Drosophila melanogaster Invertebrates p85 P85 ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates p85 P85 ncbigene_synonym Taf5 47900
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates GRB2 GRB2 ncbigene_synonym drk 36497
Drosophila melanogaster Invertebrates RAS RAS ncbigene_symbol ras 43873
Drosophila melanogaster Invertebrates RAS RAS ncbigene_synonym Ras64B 38494
Drosophila melanogaster Invertebrates RAS RAS ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates SOS SOS ncbigene_symbol Sos 34790
Drosophila melanogaster Invertebrates GAP GAP ncbigene_synonym Gapdh2 32545
Drosophila melanogaster Invertebrates GAP GAP ncbigene_synonym CdGAPr 35267
Drosophila melanogaster Invertebrates GAP GAP ncbigene_synonym Gapdh1 35728
Drosophila melanogaster Invertebrates GAP GAP ncbigene_synonym RasGAP1 39158
Drosophila melanogaster Invertebrates GAP GAP ncbigene_synonym ArfGAP1 39417
Drosophila melanogaster Invertebrates p10 P10 ncbigene_synonym elB 34844
Drosophila melanogaster Invertebrates RAF RAF ncbigene_symbol Raf 31221
Drosophila melanogaster Invertebrates PTEN PTEN ncbigene_symbol Pten 43991
Drosophila melanogaster Invertebrates TSC2 TSC2 ncbigene_synonym gig 40201
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Dsor1 31872
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Mtk 36708
Drosophila melanogaster Invertebrates (MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates (MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym Erk7 31877
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates PHLPP PHLPP ncbigene_symbol Phlpp 35178

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Cardiomyopathy NA
Lung cancer NA
Noonan syndrome NA