Kinetic Scheme for the 5-HT1AR and 5-HT2AR mediated MAP kinase activation pathway

Kinetic Scheme for the 5-HT1AR and 5-HT2AR mediated MAP kinase activation pathway. See for the corresponding reaction rates and constants. Note that the area in light gray represents the activation of PLC by 5-HT1AR activity, which is cell-type specific and not clearly demonstrated in HEK 293 cells.
Kinetic Scheme for the 5-HT1AR and 5-HT2AR mediated MAP kinase activation pathway
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Publication

Towards a Quantitative Representation of the Cell Signaling Mechanisms of Hallucinogens: Measurement and Mathematical Modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 Activation. () Chiung-wen Chang, et al. Neuropharmacology. ;56(Suppl 1):213-225. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents PLCb PLCB ncbigene_synonym Plcb1 18795
Mus musculus Rodents PIR PIR ncbigene_symbol Pir 69656
Mus musculus Rodents PIR PIR ncbigene_synonym Pira1 18722
Mus musculus Rodents PRC PRC ncbigene_synonym Pprc1 226169
Mus musculus Rodents CAS CAS ncbigene_synonym Bcar1 12927
Mus musculus Rodents CAS CAS ncbigene_synonym Cse1l 110750
Mus musculus Rodents pen PEN ncbigene_synonym Pcsk1n 30052
Mus musculus Rodents pen PEN ncbigene_synonym Tspan33 232670
Mus musculus Rodents Te TE ncbigene_symbol te 21675
Mus musculus Rodents hrs HRS ncbigene_synonym Hgs 15239
Mus musculus Rodents PPN, PPN ncbigene_synonym Porcn 53627
Mus musculus Rodents DAs DAS ncbigene_symbol Das 107419
Mus musculus Rodents AA AA ncbigene_synonym H2-Aa 14960
Mus musculus Rodents APC APC ncbigene_symbol Apc 11789
Mus musculus Rodents PAC PAC ncbigene_synonym Pacc1 66950
Mus musculus Rodents PLAT PLAT ncbigene_symbol Plat 18791
Mus musculus Rodents Cat CAT ncbigene_symbol Cat 12359
Mus musculus Rodents Cat CAT ncbigene_synonym cac 12285
Mus musculus Rodents Cat CAT ncbigene_synonym Mip 17339
Mus musculus Rodents Cat CAT ncbigene_synonym Trpv6 64177
Mus musculus Rodents Cat CAT ncbigene_synonym Glyat 107146
Mus musculus Rodents RAI RAI ncbigene_synonym Shc3 20418
Mus musculus Rodents PN PN ncbigene_symbol pn 18936
Mus musculus Rodents MPN MPN ncbigene_synonym Prss27 213171
Mus musculus Rodents MEK MEK ncbigene_synonym Mdk 17242
Mus musculus Rodents PKE PKE ncbigene_synonym Dmd 13405
Mus musculus Rodents PKE PKE ncbigene_synonym Stk32c 57740
Mus musculus Rodents AC AC ncbigene_symbol ac 11358
Mus musculus Rodents ERK ERK ncbigene_synonym Ephb2 13844
Mus musculus Rodents ERK ERK ncbigene_synonym Mapk1 26413
Mus musculus Rodents pERK PERK ncbigene_synonym Eif2ak3 13666
Mus musculus Rodents pERK PERK ncbigene_synonym Lamp1 16783
Mus musculus Rodents MP MP ncbigene_symbol Mp 104327
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates PLCb PLCB famplex_relations PLCB1 23236
Homo sapiens Primates PLCb PLCB famplex_relations PLCB2 5330
Homo sapiens Primates PLCb PLCB famplex_relations PLCB3 5331
Homo sapiens Primates PLCb PLCB famplex_relations PLCB4 5332
Homo sapiens Primates +a.T.C- ATC ncbigene_synonym ATM 472
Homo sapiens Primates PIR PIR ncbigene_symbol PIR 8544
Homo sapiens Primates PRC PRC ncbigene_synonym PPRC1 23082
Homo sapiens Primates CAS CAS ncbigene_synonym CSE1L 1434
Homo sapiens Primates CAS CAS ncbigene_synonym CTNND1 1500
Homo sapiens Primates CAS CAS ncbigene_synonym BCAR1 9564
Homo sapiens Primates CAS CAS ncbigene_synonym TMX2-CTNND1 100528016
Homo sapiens Primates PKC PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKC PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKC PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKC PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKC PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKC PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKC PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKC PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKC PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKC PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKC PKC famplex_relations PRKD3 23683
Homo sapiens Primates pen PEN ncbigene_synonym PUM3 9933
Homo sapiens Primates pen PEN ncbigene_synonym PCSK1N 27344
Homo sapiens Primates pen PEN ncbigene_synonym TSPAN33 340348
Homo sapiens Primates hrs HRS ncbigene_synonym ATN1 1822
Homo sapiens Primates hrs HRS ncbigene_synonym HARS1 3035
Homo sapiens Primates hrs HRS ncbigene_synonym SRSF5 6430
Homo sapiens Primates hrs HRS ncbigene_synonym HGS 9146
Homo sapiens Primates PPN, PPN ncbigene_synonym PORCN 64840
Homo sapiens Primates PPN, PPN ncbigene_synonym PAPLN 89932
Homo sapiens Primates APC APC ncbigene_symbol APC 324
Homo sapiens Primates APC APC ncbigene_synonym PROC 5624
Homo sapiens Primates PAC PAC ncbigene_synonym PACC1 55248
Homo sapiens Primates PLAT PLAT ncbigene_symbol PLAT 5327
Homo sapiens Primates Cat CAT ncbigene_symbol CAT 847
Homo sapiens Primates Cat CAT ncbigene_synonym CRAT 1384
Homo sapiens Primates Cat CAT ncbigene_synonym GLYAT 10249
Homo sapiens Primates RAI RAI ncbigene_synonym GDF1 2657
Homo sapiens Primates RAI RAI ncbigene_synonym RNH1 6050
Homo sapiens Primates RAI RAI ncbigene_synonym PPP1R13L 10848
Homo sapiens Primates RAI RAI ncbigene_synonym SHC3 53358
Homo sapiens Primates Sos SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates Sos SOS famplex_relations SOS1 6654
Homo sapiens Primates Sos SOS famplex_relations SOS2 6655
Homo sapiens Primates MPN MPN ncbigene_synonym PRSS27 83886
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates PKE PKE ncbigene_synonym STK32C 282974
Homo sapiens Primates AC ADCY famplex_relations ADCY1 107
Homo sapiens Primates AC ADCY famplex_relations ADCY2 108
Homo sapiens Primates AC ADCY famplex_relations ADCY3 109
Homo sapiens Primates AC ADCY famplex_relations ADCY4 196883
Homo sapiens Primates AC ADCY famplex_relations ADCY5 111
Homo sapiens Primates AC ADCY famplex_relations ADCY6 112
Homo sapiens Primates AC ADCY famplex_relations ADCY7 113
Homo sapiens Primates AC ADCY famplex_relations ADCY8 114
Homo sapiens Primates AC ADCY famplex_relations ADCY9 115
Homo sapiens Primates AC ADCY famplex_relations ADCY10 55811
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates pERK PERK ncbigene_synonym EIF2AK3 9451
Rattus norvegicus Rodents PIR PIR ncbigene_symbol Pir 363465
Rattus norvegicus Rodents CAS CAS ncbigene_synonym Bcar1 25414
Rattus norvegicus Rodents PKC PKC ncbigene_synonym Prkcg 24681
Rattus norvegicus Rodents hrs HRS ncbigene_synonym Srsf5 29667
Rattus norvegicus Rodents hrs HRS ncbigene_synonym Hgs 56084
Rattus norvegicus Rodents APC APC ncbigene_symbol Apc 24205
Rattus norvegicus Rodents PAC PAC ncbigene_synonym Pacc1 305070
Rattus norvegicus Rodents PLAT PLAT ncbigene_symbol Plat 25692
Rattus norvegicus Rodents Cat CAT ncbigene_symbol Cat 24248
Rattus norvegicus Rodents MPN MPN ncbigene_synonym Prss27 287108
Rattus norvegicus Rodents ERK ERK ncbigene_synonym Ephb1 24338
Bos taurus Mammals PIR PIR ncbigene_symbol PIR 790878
Bos taurus Mammals hrs HRS ncbigene_synonym HGS 511582
Bos taurus Mammals APC APC ncbigene_symbol APC 533233
Bos taurus Mammals PAC PAC ncbigene_synonym PACC1 616392
Bos taurus Mammals PLAT PLAT ncbigene_symbol PLAT 281407
Bos taurus Mammals Cat CAT ncbigene_symbol CAT 531682
Oryctolagus cuniculus Mammals PIR PIR ncbigene_symbol PIR 100350592
Oryctolagus cuniculus Mammals APC APC ncbigene_symbol APC 100353976
Oryctolagus cuniculus Mammals PLAT PLAT ncbigene_symbol PLAT 100009556
Oryctolagus cuniculus Mammals Cat CAT ncbigene_symbol CAT 100340891
Oryctolagus cuniculus Mammals Rs_C RSC ncbigene_synonym RAD23A 100009238
Xenopus laevis Vertebrates MAPK MAPK ncbigene_synonym mapk1.L 397785
Xenopus laevis Vertebrates MAPK MAPK ncbigene_synonym mapk1.S 398985
Xenopus laevis Vertebrates PIR PIR ncbigene_synonym adcyap1r1.S 373615
Xenopus laevis Vertebrates PIR PIR ncbigene_synonym pir.L 379306
Xenopus laevis Vertebrates PIR PIR ncbigene_synonym adcyap1r1.L 108718462
Xenopus laevis Vertebrates PRC PRC ncbigene_synonym pprc1.L 108696159
Xenopus laevis Vertebrates pen PEN ncbigene_synonym kpna2.S 380125
Xenopus laevis Vertebrates hrs HRS ncbigene_synonym srsf5.S 432350
Xenopus laevis Vertebrates hrs HRS ncbigene_synonym atn1.L 108696045
Xenopus laevis Vertebrates hrs HRS ncbigene_synonym atn1.S 108697336
Xenopus laevis Vertebrates hrs HRS ncbigene_synonym srsf5.L 108699194
Xenopus laevis Vertebrates APC APC ncbigene_synonym apc.L 399455
Xenopus laevis Vertebrates PAC PAC ncbigene_synonym pacc1.L 779252
Xenopus laevis Vertebrates PLAT PLAT ncbigene_synonym plat.L 399010
Xenopus laevis Vertebrates Cat CAT ncbigene_synonym cat.2.L 380236
Xenopus laevis Vertebrates Cat CAT ncbigene_synonym cat.1.L 495840
Xenopus laevis Vertebrates MPN MPN ncbigene_synonym tpsg1.S 443716
Xenopus laevis Vertebrates MPN MPN ncbigene_synonym xepsin.S 779376
Xenopus laevis Vertebrates RGAP RGAP ncbigene_synonym arhgap21.L 398972
Drosophila melanogaster Invertebrates deg DEG ncbigene_symbol deg 43880
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym MKP-4 32963
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym p38b 34780
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates PLCb PLCB ncbigene_synonym norpA 31376
Drosophila melanogaster Invertebrates +a.T.C- ATC ncbigene_synonym Srpk79D 40461
Drosophila melanogaster Invertebrates GGE GGE ncbigene_synonym Ggamma30A 45234
Drosophila melanogaster Invertebrates PLO PLO ncbigene_symbol plo 45916
Drosophila melanogaster Invertebrates PIR PIR ncbigene_synonym mRNA-cap 32379
Drosophila melanogaster Invertebrates PRC PRC ncbigene_symbol prc 43930
Drosophila melanogaster Invertebrates CAS CAS ncbigene_symbol cas 44018
Drosophila melanogaster Invertebrates CAS CAS ncbigene_synonym caz 32587
Drosophila melanogaster Invertebrates CAS CAS ncbigene_synonym Cse1 35016
Drosophila melanogaster Invertebrates CAS CAS ncbigene_synonym cass 35053
Drosophila melanogaster Invertebrates CAS CAS ncbigene_synonym cash 47266
Drosophila melanogaster Invertebrates PE PE ncbigene_symbol pe 252319
Drosophila melanogaster Invertebrates Ca CA ncbigene_symbol ca 43518
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym inaC 36897
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym Pkc98E 43428
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym aPKC 47594
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym Pkc53E 48311
Drosophila melanogaster Invertebrates pen PEN ncbigene_symbol Pen 34338
Drosophila melanogaster Invertebrates pen PEN ncbigene_synonym peng 33112
Drosophila melanogaster Invertebrates pen PEN ncbigene_synonym peo 47272
Drosophila melanogaster Invertebrates Te TE ncbigene_symbol te 252809
Drosophila melanogaster Invertebrates hrs HRS ncbigene_symbol Hrs 33458
Drosophila melanogaster Invertebrates hrs HRS ncbigene_synonym HisRS 32841
Drosophila melanogaster Invertebrates PPN, PPN ncbigene_symbol Ppn 43872
Drosophila melanogaster Invertebrates PPN, PPN ncbigene_synonym PpN58A 37493
Drosophila melanogaster Invertebrates DAs DAS ncbigene_synonym nAChRalpha6 34304
Drosophila melanogaster Invertebrates DAs DAS ncbigene_synonym Ube3a 39266
Drosophila melanogaster Invertebrates AA AA ncbigene_symbol aa 44792
Drosophila melanogaster Invertebrates Ses SES ncbigene_synonym Sps1 36587
Drosophila melanogaster Invertebrates APC APC ncbigene_symbol Apc 44642
Drosophila melanogaster Invertebrates APC APC ncbigene_synonym Apc2 42871
Drosophila melanogaster Invertebrates APC APC ncbigene_synonym Axn 43565
Drosophila melanogaster Invertebrates APC APC ncbigene_synonym Fs(3)Apc 49116
Drosophila melanogaster Invertebrates Cat CAT ncbigene_symbol Cat 40048
Drosophila melanogaster Invertebrates Cat CAT ncbigene_synonym Ca-alpha1T 31550
Drosophila melanogaster Invertebrates Cat CAT ncbigene_synonym ChAT 42249
Drosophila melanogaster Invertebrates Cat CAT ncbigene_synonym sv 43825
Drosophila melanogaster Invertebrates RAI RAI ncbigene_symbol rai 252476
Drosophila melanogaster Invertebrates PAE PAE ncbigene_synonym Sp7 40918
Drosophila melanogaster Invertebrates Sos SOS ncbigene_symbol Sos 34790
Drosophila melanogaster Invertebrates PN PN ncbigene_symbol pn 31194
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Dsor1 31872
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Mtk 36708
Drosophila melanogaster Invertebrates RC RC ncbigene_symbol rc 5656968
Drosophila melanogaster Invertebrates AC AC ncbigene_symbol ac 30981
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym Erk7 31877
Drosophila melanogaster Invertebrates pERK PERK ncbigene_synonym PEK 40653
Drosophila melanogaster Invertebrates Rs_C RSC ncbigene_symbol rsc 5656974
Drosophila melanogaster Invertebrates MP MP ncbigene_symbol Mp 38769

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID