The HMGCR pathway

The HMGCR pathway. HMGCR is the rate-limiting enzyme that converts HMG-CoA into mevalonate. Mevalonate serves as a precursor for the synthesis of both cholesterol and isoprenoids. Enzymes inhibited in this study are indicated in red.
The HMGCR pathway
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Publication

Inhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse. (2008) Jiaxi Ding, et al. BMC Dev Biol. 2008;8:120-120. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Bos taurus Mammals HMG-COA HMGCOA ncbigene_synonym HMGCS2 503684
Bos taurus Mammals HMGCR HMGCR ncbigene_symbol HMGCR 407159
Bos taurus Mammals SC5D SC5D ncbigene_symbol SC5D 525154
Bos taurus Mammals DHCR7 DHCR7 ncbigene_symbol DHCR7 514745
Mus musculus Rodents HMGCR HMGCR ncbigene_symbol Hmgcr 15357
Mus musculus Rodents SC5D SC5D ncbigene_symbol Sc5d 235293
Mus musculus Rodents DHCR7 DHCR7 ncbigene_symbol Dhcr7 13360
Capra hircus Mammals HMGCR HMGCR ncbigene_symbol HMGCR 102169762
Capra hircus Mammals SC5D SC5D ncbigene_symbol SC5D 102180515
Capra hircus Mammals DHCR7 DHCR7 ncbigene_symbol DHCR7 102171848
Homo sapiens Primates HMGCR HMGCR ncbigene_symbol HMGCR 3156
Homo sapiens Primates SC5D SC5D ncbigene_symbol SC5D 6309
Homo sapiens Primates DHCR7 DHCR7 ncbigene_symbol DHCR7 1717

Chemical mentions

Word Match MeSH Name ChEBI
Lathosterol 5alpha-cholest-7-en-3beta-ol mesh:C001521 lathosterol chebi:17168
7-dehydrocholesterol NA mesh:C016705
Bile Acids NA mesh:D001647
Cholesterol Cholesterol mesh:D002784 cholesterol chebi:16113
Mevalonate NA mesh:D008798
Squalene Squalene mesh:D013185 squalene chebi:15440
Steroids Steroids mesh:D013256 steroid chebi:35341
Isoprenoid terpene mesh:D013729 Terpenes chebi:35186
Ubiquinone Ubiquinone mesh:D014451 ubiquinones chebi:16389

Disease mentions

Word Match MeSH Name DOID