Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus

Biological network of selected genes that were only induced more than twofold (P < 0.01) in the r1918-infected mouse lung compared with uninfected controls. This diagram shows the direct (solid lines) and indirect (dashed lines) interactions reported for these cell-death-related (blue shading) and immune-response-related (yellow shading) genes; grey denotes genes with multiple and/or undefined biological functions. Biological network analysis was performed by using Ingenuity Pathway Analysis and showed statistical significance with Fisher’s exact test to calculate a P-value determining the probability that each biological function and/or disease assigned to that data set was due to chance alone (see Methods for details).
Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus
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Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. () John C. Kash, et al. Nature. ;443(7111):578-581. Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates CALR CALR ncbigene_symbol CALR 811
Homo sapiens Primates ATF3 ATF3 ncbigene_symbol ATF3 467
Homo sapiens Primates CTSL2 CTSL2 ncbigene_synonym CTSV 1515
Homo sapiens Primates PLAT PLAT ncbigene_symbol PLAT 5327
Homo sapiens Primates SPI1 SPI1 ncbigene_symbol SPI1 6688
Homo sapiens Primates FBN1 FBN1 ncbigene_symbol FBN1 2200
Homo sapiens Primates FOS FOS ncbigene_symbol FOS 2353
Homo sapiens Primates FOS FOS famplex_relations FOSB 2354
Homo sapiens Primates FOS FOS famplex_relations FOSL1 8061
Homo sapiens Primates FOS FOS famplex_relations FOSL2 2355
Homo sapiens Primates SLC20A2 SLC20A2 ncbigene_symbol SLC20A2 6575
Homo sapiens Primates PLAUR PLAUR ncbigene_symbol PLAUR 5329
Homo sapiens Primates RYBP RYBP ncbigene_symbol RYBP 23429
Homo sapiens Primates ČSF3 CSF3 ncbigene_symbol CSF3 1440
Homo sapiens Primates ZBTB7 ZBTB7 ncbigene_synonym ZBTB7A 51341
Homo sapiens Primates LGALS3 LGALS3 ncbigene_symbol LGALS3 3958
Homo sapiens Primates RBL1 RBL1 ncbigene_symbol RBL1 5933
Homo sapiens Primates TIMP3 TIMP3 ncbigene_symbol TIMP3 7078
Homo sapiens Primates CASP8 CASP8 ncbigene_symbol CASP8 841
Homo sapiens Primates DATF1 DATF1 ncbigene_synonym DIDO1 11083
Homo sapiens Primates PRRX1 PRRX1 ncbigene_symbol PRRX1 5396
Homo sapiens Primates TMEM23 TMEM23 ncbigene_synonym SGMS1 259230
Homo sapiens Primates FAS FAS ncbigene_symbol FAS 355
Homo sapiens Primates FAS FAS ncbigene_synonym FASN 2194
Homo sapiens Primates CASP9 CASP9 ncbigene_symbol CASP9 842
Homo sapiens Primates BMPR1B BMPR1B ncbigene_symbol BMPR1B 658
Homo sapiens Primates CD47 CD47 ncbigene_symbol CD47 961
Homo sapiens Primates L11 L11 ncbigene_synonym RPL11 6135
Homo sapiens Primates L11 L11 ncbigene_synonym IGKV1-6 28943
Homo sapiens Primates L11 L11 ncbigene_synonym JPT2 90861
Mus musculus Rodents CALR CALR ncbigene_symbol Calr 12317
Mus musculus Rodents ATF3 ATF3 ncbigene_symbol Atf3 11910
Mus musculus Rodents PLAT PLAT ncbigene_symbol Plat 18791
Mus musculus Rodents SPI1 SPI1 ncbigene_symbol Spi1 20375
Mus musculus Rodents SPI1 SPI1 ncbigene_synonym Serpina3d-ps 435318
Mus musculus Rodents FBN1 FBN1 ncbigene_symbol Fbn1 14118
Mus musculus Rodents FOS FOS ncbigene_symbol Fos 14281
Mus musculus Rodents SLC20A2 SLC20A2 ncbigene_symbol Slc20a2 20516
Mus musculus Rodents PLAUR PLAUR ncbigene_symbol Plaur 18793
Mus musculus Rodents RYBP RYBP ncbigene_symbol Rybp 56353
Mus musculus Rodents ČSF3 CSF3 ncbigene_symbol Csf3 12985
Mus musculus Rodents ZBTB7 ZBTB7 ncbigene_synonym Zbtb7a 16969
Mus musculus Rodents LGALS3 LGALS3 ncbigene_symbol Lgals3 16854
Mus musculus Rodents RBL1 RBL1 ncbigene_symbol Rbl1 19650
Mus musculus Rodents TIMP3 TIMP3 ncbigene_symbol Timp3 21859
Mus musculus Rodents CASP8 CASP8 ncbigene_symbol Casp8 12370
Mus musculus Rodents DATF1 DATF1 ncbigene_synonym Dido1 23856
Mus musculus Rodents PRRX1 PRRX1 ncbigene_symbol Prrx1 18933
Mus musculus Rodents TMEM23 TMEM23 ncbigene_synonym Sgms1 208449
Mus musculus Rodents FAS FAS ncbigene_symbol Fas 14102
Mus musculus Rodents FAS FAS ncbigene_synonym Fasn 14104
Mus musculus Rodents CASP9 CASP9 ncbigene_symbol Casp9 12371
Mus musculus Rodents BMPR1B BMPR1B ncbigene_symbol Bmpr1b 12167
Mus musculus Rodents CD47 CD47 ncbigene_symbol Cd47 16423
Mus musculus Rodents L11 L11 ncbigene_synonym Skull16 114724
Danio rerio Vertebrates CALR CALR ncbigene_symbol calr 325317
Danio rerio Vertebrates CALR CALR ncbigene_synonym calr3a 30248
Danio rerio Vertebrates ATF3 ATF3 ncbigene_symbol atf3 393939
Danio rerio Vertebrates PLAT PLAT ncbigene_symbol plat 100320028
Danio rerio Vertebrates SPI1 SPI1 ncbigene_synonym spi1b 30117
Danio rerio Vertebrates FBN1 FBN1 ncbigene_symbol fbn1 100330961
Danio rerio Vertebrates FOS FOS ncbigene_synonym fosab 394198
Danio rerio Vertebrates SLC20A2 SLC20A2 ncbigene_symbol slc20a2 558346
Danio rerio Vertebrates RYBP RYBP ncbigene_synonym rybpa 368248
Danio rerio Vertebrates ČSF3 CSF3 ncbigene_synonym csf3b 100190920
Danio rerio Vertebrates ČSF3 CSF3 ncbigene_synonym csf3a 100270759
Danio rerio Vertebrates LGALS3 LGALS3 ncbigene_synonym lgals3a 557373
Danio rerio Vertebrates RBL1 RBL1 ncbigene_symbol rbl1 795522
Danio rerio Vertebrates CASP8 CASP8 ncbigene_symbol casp8 58022
Danio rerio Vertebrates PRRX1 PRRX1 ncbigene_synonym prrx1a 406431
Danio rerio Vertebrates FAS FAS ncbigene_symbol fas 768248
Danio rerio Vertebrates CASP9 CASP9 ncbigene_symbol casp9 492763
Danio rerio Vertebrates BMPR1B BMPR1B ncbigene_synonym bmpr1ba 30742

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID