Canonical and noncanonical NFKB signaling pathways

The canonical and noncanonical NF-κB signaling pathways. The canonical pathway is critical for the activation of innate immunity and inflammation (left). It is activated by TNFα, IL-1, and lipopolysaccharide. Activation of this pathway depends on the IKKα/IKKβ/IKKγ complex, which phosphorylates IκB proteins to trigger their degradation through β-TrCP ubiquitin proteasome. The noncanonical pathway is crucial for the activation of adaptive immunity (right). It is activated by lipopolysaccharide, B cell – activating factor of the TNF family, and latent membrane protein 1. Activation of this pathway depends on IKKα homodimers which phosphorylate p100 to induce p100/RELB heterodimers processing intop52/RELB heterodimers.

Publication

Advances in Targeting IKK and IKK-Related Kinases for Cancer Therapy. () Dung-Fang Lee, et al. Clin Cancer Res. ;14(18):5656-5662. Figure: F1. All organisms Homo sapiens Mus musculus Danio rerio

Disease mentions