Schematic view of the Vav family-regulated signaling pathways of DT40 B-cells

A schematic view of the Vav family-regulated signaling pathways of DT40 B-cells. The main signal transduction molecules with positive roles in downstream signaling are indicated in black (the ones analyzed in this work) and blue (the ones not analyzed in our experiments). Putative negative regulators of B-cell signaling that could be operating in this pathway are shown in red. The main second messengers are indicated in green. Black thick arrows highlight the prevalence of a signaling pathway over the rest of the signaling connections presented in the figure. Gray arrows indicate pathways that have not been demonstrated yet in DT40 cells. See main text for further information.
Schematic view of the Vav family-regulated signaling pathways of DT40 B-cells
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Publication

Mechanistic Analysis of the Amplification and Diversification Events Induced by Vav Proteins in B-lymphocytes. (2008) María J. Caloca, et al. J Biol Chem. 2008 Dec 26;283(52):36454-36464. Figure: F9.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates BCR BCR ncbigene_symbol BCR 613
Homo sapiens Primates BCR BCR ncbigene_synonym RN7SL263P 106480993
Homo sapiens Primates Src SRC ncbigene_symbol SRC 6714
Homo sapiens Primates Src SRC famplex_relations FGR 2268
Homo sapiens Primates Src SRC famplex_relations FYN 2534
Homo sapiens Primates Src SRC famplex_relations YES1 7525
Homo sapiens Primates Syk SYK ncbigene_symbol SYK 6850
Homo sapiens Primates p110a P110A ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3-Ks PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3-Ks PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3-Ks PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3-Ks PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3-Ks PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3-Ks PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3-Ks PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3-Ks PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3-Ks PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates Vav3 VAV3 ncbigene_symbol VAV3 10451
Homo sapiens Primates Vav3/Blnk BLNK ncbigene_symbol BLNK 29760
Homo sapiens Primates Rac1 RAC1 ncbigene_symbol RAC1 5879
Homo sapiens Primates Rac1 RAC1 ncbigene_synonym RNASE1 6035
Homo sapiens Primates RhoA RHOA ncbigene_symbol RHOA 387
Homo sapiens Primates SHIP SHIP ncbigene_synonym INPP5D 3635
Homo sapiens Primates Btk BTK ncbigene_symbol BTK 695
Homo sapiens Primates PLD1 PLD1 ncbigene_symbol PLD1 5337
Homo sapiens Primates PLD1 PLD1 ncbigene_synonym PRKCSH 5589
Homo sapiens Primates PAP PAP ncbigene_synonym REG3A 5068
Homo sapiens Primates PAP PAP ncbigene_synonym ASAP2 8853
Homo sapiens Primates PAP PAP ncbigene_synonym MRPS30 10884
Homo sapiens Primates PAP PAP ncbigene_synonym PAPOLA 10914
Homo sapiens Primates PAP PAP ncbigene_synonym PDAP1 11333
Homo sapiens Primates PAP PAP ncbigene_synonym TUSC2 11334
Homo sapiens Primates PAP PAP ncbigene_synonym ASAP1 50807
Homo sapiens Primates DAGK DAGK ncbigene_synonym DGKA 1606
Homo sapiens Primates DAGK DAGK ncbigene_synonym DGKQ 1609
Homo sapiens Primates RasGRP3 RASGRP3 ncbigene_symbol RASGRP3 25780
Homo sapiens Primates CAPRI CAPRI ncbigene_synonym RASA4 10156
Homo sapiens Primates Grb2/ GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates Sos SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates Sos SOS famplex_relations SOS1 6654
Homo sapiens Primates Sos SOS famplex_relations SOS2 6655
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates PKCA PKCA ncbigene_synonym PRKCA 5578
Homo sapiens Primates Raf RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates Raf RAF famplex_relations ARAF 369
Homo sapiens Primates Raf RAF famplex_relations BRAF 673
Homo sapiens Primates Raf RAF famplex_relations RAF1 5894
Homo sapiens Primates PKCE PKCE ncbigene_synonym PRKCE 5581
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates PKB PKB ncbigene_synonym AKT1 207
Homo sapiens Primates PKB PKB ncbigene_synonym PTK2B 2185
Homo sapiens Primates Erk ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates Erk ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates Erk ERK famplex_relations MAPK3 5595
Homo sapiens Primates PKD PKD ncbigene_synonym PRKD1 5587
Gallus gallus Vertebrates BCR BCR ncbigene_symbol BCR 416952
Gallus gallus Vertebrates Src SRC ncbigene_symbol SRC 396442
Gallus gallus Vertebrates Syk SYK ncbigene_symbol SYK 427272
Gallus gallus Vertebrates Vav3 VAV3 ncbigene_symbol VAV3 373939
Gallus gallus Vertebrates Vav3/Blnk BLNK ncbigene_synonym SH2D6 395733
Gallus gallus Vertebrates Rac1 RAC1 ncbigene_symbol RAC1 395871
Gallus gallus Vertebrates RhoA RHOA ncbigene_symbol RHOA 395442
Gallus gallus Vertebrates Btk BTK ncbigene_symbol BTK 374075
Gallus gallus Vertebrates PLD1 PLD1 ncbigene_symbol PLD1 424986
Gallus gallus Vertebrates RasGRP3 RASGRP3 ncbigene_symbol RASGRP3 421460
Gallus gallus Vertebrates Grb2/ GRB2 ncbigene_symbol GRB2 386572
Drosophila melanogaster Invertebrates BCR BCR ncbigene_synonym RhoGAP1A 5740235
Drosophila melanogaster Invertebrates Src SRC ncbigene_synonym Src42A 35524
Drosophila melanogaster Invertebrates Src SRC ncbigene_synonym Csk 41398
Drosophila melanogaster Invertebrates Src SRC ncbigene_synonym Src64B 48973
Drosophila melanogaster Invertebrates Syk SYK ncbigene_synonym Shark 44353
Drosophila melanogaster Invertebrates PI3-Ks PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3-Ks PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3-Ks PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3-Ks PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates Rac1 RAC1 ncbigene_symbol Rac1 38146
Drosophila melanogaster Invertebrates Rac1 RAC1 ncbigene_synonym Rac2 38831
Drosophila melanogaster Invertebrates RhoA RHOA ncbigene_synonym Rho1 36775
Drosophila melanogaster Invertebrates Btk BTK ncbigene_symbol Btk 34132
Drosophila melanogaster Invertebrates PLD1 PLD1 ncbigene_synonym Pld 35554
Drosophila melanogaster Invertebrates PA PA ncbigene_symbol Pa 251550
Drosophila melanogaster Invertebrates PAP PAP ncbigene_synonym wisp 32152
Drosophila melanogaster Invertebrates PAP PAP ncbigene_synonym PAPLA1 34109
Drosophila melanogaster Invertebrates PAP PAP ncbigene_synonym Pli 42821
Drosophila melanogaster Invertebrates PAP PAP ncbigene_synonym Pdf 43193
Drosophila melanogaster Invertebrates PAP PAP ncbigene_synonym skd 43906
Drosophila melanogaster Invertebrates PAP PAP ncbigene_synonym hrg 49636
Drosophila melanogaster Invertebrates DAGK DAGK ncbigene_synonym Dgk 35738
Drosophila melanogaster Invertebrates Grb2/ GRB2 ncbigene_synonym drk 36497
Drosophila melanogaster Invertebrates Sos SOS ncbigene_symbol Sos 34790
Drosophila melanogaster Invertebrates Ras RAS ncbigene_symbol ras 43873
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras64B 38494
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates Raf RAF ncbigene_symbol Raf 31221
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Dsor1 31872
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Mtk 36708
Drosophila melanogaster Invertebrates PKB PKB ncbigene_synonym Akt 41957
Drosophila melanogaster Invertebrates Erk ERK ncbigene_synonym Erk7 31877
Drosophila melanogaster Invertebrates Erk ERK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates PKD PKD ncbigene_symbol PKD 42203
Danio rerio Vertebrates BCR BCR ncbigene_symbol bcr 568320
Danio rerio Vertebrates Src SRC ncbigene_symbol src 325084
Danio rerio Vertebrates Syk SYK ncbigene_symbol syk 405769
Danio rerio Vertebrates p110a P110A ncbigene_synonym ddx3xb 30116
Danio rerio Vertebrates Vav3 VAV3 ncbigene_symbol vav3 100333179
Danio rerio Vertebrates Vav3/Blnk BLNK ncbigene_symbol blnk 405764
Danio rerio Vertebrates Rac1 RAC1 ncbigene_synonym rac1a 327204
Danio rerio Vertebrates RhoA RHOA ncbigene_synonym rhoaa 406411
Danio rerio Vertebrates RhoA RHOA ncbigene_synonym rhoab 100006041
Danio rerio Vertebrates Btk BTK ncbigene_symbol btk 568653
Danio rerio Vertebrates PLD1 PLD1 ncbigene_synonym pld1a 556641
Danio rerio Vertebrates RasGRP3 RASGRP3 ncbigene_symbol rasgrp3 563441
Danio rerio Vertebrates Grb2/ GRB2 ncbigene_synonym grb2b 406308
Danio rerio Vertebrates Ras RAS ncbigene_synonym rab1ab 368883

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Cardiomyopathy NA
Noonan syndrome NA