Hierarchical layout of the B-cell receptor pathway downloaded from the HPRD pathway database

Hierarchical layout of the B-cell receptor pathway downloaded from the HPRD pathway database []. The optimal layout was achieved at 5 hierarchical levels. Two predicted anti-hierarchical links are shown in red.
Hierarchical layout of the B-cell receptor pathway downloaded from the HPRD pathway database
Download JPG
View figure at PMC Read paper at PMC Open at NDEx
PMC
NDEx

Publication

Detection of the dominant direction of information flow and feedback links in densely interconnected regulatory networks. (2008) Iaroslav Ispolatov, et al. BMC Bioinformatics. 2008;9:424-424. Figure: F6.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates CASP9 CASP9 ncbigene_symbol CASP9 842
Homo sapiens Primates CASP7 CASP7 ncbigene_symbol CASP7 840
Homo sapiens Primates FYN FYN ncbigene_symbol FYN 2534
Homo sapiens Primates PRKD1 PRKD1 ncbigene_symbol PRKD1 5587
Homo sapiens Primates BTK,RASGRP3PILBBIKKBKBBCARLPTK2BCARD11 BTK ncbigene_symbol BTK 695
Homo sapiens Primates IK IK ncbigene_symbol IK 3550
Homo sapiens Primates PTK2B PTK2B ncbigene_symbol PTK2B 2185
Homo sapiens Primates CARD11 CARD11 ncbigene_symbol CARD11 84433
Homo sapiens Primates TEC TEC ncbigene_symbol TEC 7006
Homo sapiens Primates TEC TEC ncbigene_symbol TEC 100124696
Homo sapiens Primates SYK SYK ncbigene_symbol SYK 6850
Homo sapiens Primates CD22 CD22 ncbigene_symbol CD22 933
Homo sapiens Primates HCLS1 HCLS1 ncbigene_symbol HCLS1 3059
Homo sapiens Primates CBL CBL ncbigene_symbol CBL 867
Homo sapiens Primates CD79B CD79B ncbigene_symbol CD79B 974
Homo sapiens Primates MAPK3 MAPK3 ncbigene_symbol MAPK3 5595
Homo sapiens Primates PTPN18 PTPN18 ncbigene_symbol PTPN18 26469
Homo sapiens Primates RPS6KA1 RPS6KA1 ncbigene_symbol RPS6KA1 6195
Homo sapiens Primates PLCG2 PLCG2 ncbigene_symbol PLCG2 5336
Homo sapiens Primates CP2 CP2 ncbigene_synonym CP 1356
Homo sapiens Primates BLNK BLNK ncbigene_symbol BLNK 29760
Homo sapiens Primates PIK3AP1 PIK3AP1 ncbigene_symbol PIK3AP1 118788
Homo sapiens Primates SHC1 SHC1 ncbigene_symbol SHC1 6464
Homo sapiens Primates CREB1 CREB1 ncbigene_symbol CREB1 1385
Homo sapiens Primates CDK4 CDK4 ncbigene_symbol CDK4 1019
Homo sapiens Primates CDK2 CDK2 ncbigene_symbol CDK2 1017
Homo sapiens Primates CDK6 CDK6 ncbigene_symbol CDK6 1021
Homo sapiens Primates MAPK8 MAPK8 ncbigene_symbol MAPK8 5599
Homo sapiens Primates MAPK14 MAPK14 ncbigene_symbol MAPK14 1432
Homo sapiens Primates PIK3R2 PIK3R2 ncbigene_symbol PIK3R2 5296
Homo sapiens Primates RB1 RB1 ncbigene_symbol RB1 5925
Homo sapiens Primates RB1 RB1 ncbigene_synonym RBM45 129831
Homo sapiens Primates PPP3CA PPP3CA ncbigene_symbol PPP3CA 5530
Homo sapiens Primates PPP3R1 PPP3R1 ncbigene_symbol PPP3R1 5534
Homo sapiens Primates AKT1 AKT1 ncbigene_symbol AKT1 207
Homo sapiens Primates MAPK1 MAPK1 ncbigene_symbol MAPK1 5594
Homo sapiens Primates RPS6KB1 RPS6KB1 ncbigene_symbol RPS6KB1 6198
Homo sapiens Primates NFATC1 NFATC1 ncbigene_symbol NFATC1 4772
Homo sapiens Primates NFATC3 NFATC3 ncbigene_symbol NFATC3 4775
Homo sapiens Primates NFATC2 NFATC2 ncbigene_symbol NFATC2 4773
Homo sapiens Primates ELK1 ELK1 ncbigene_symbol ELK1 2002
Homo sapiens Primates ELK1 ELK1 ncbigene_synonym KCNH4 23415
Homo sapiens Primates ELK1 ELK1 ncbigene_synonym KCNH8 131096
Homo sapiens Primates GSK3B GSK3B ncbigene_symbol GSK3B 2932
Homo sapiens Primates RPS6 RPS6 ncbigene_symbol RPS6 6194
Homo sapiens Primates BCL6 BCL6 ncbigene_symbol BCL6 604
Homo sapiens Primates BRAF BRAF ncbigene_symbol BRAF 673
Homo sapiens Primates GSK3A GSK3A ncbigene_symbol GSK3A 2931
Danio rerio Vertebrates CASP9 CASP9 ncbigene_symbol casp9 492763
Danio rerio Vertebrates CASP7 CASP7 ncbigene_symbol casp7 553634
Danio rerio Vertebrates FYN FYN ncbigene_synonym fyna 373872
Danio rerio Vertebrates PRKD1 PRKD1 ncbigene_symbol prkd1 557123
Danio rerio Vertebrates BTK,RASGRP3PILBBIKKBKBBCARLPTK2BCARD11 BTK ncbigene_symbol btk 568653
Danio rerio Vertebrates IK IK ncbigene_symbol ik 322241
Danio rerio Vertebrates PTK2B PTK2B ncbigene_synonym ptk2bb 245950
Danio rerio Vertebrates PTK2B PTK2B ncbigene_synonym ptk2aa 386705
Danio rerio Vertebrates CARD11 CARD11 ncbigene_symbol card11 557072
Danio rerio Vertebrates TEC TEC ncbigene_symbol tec 571588
Danio rerio Vertebrates TEC TEC ncbigene_synonym itk 798906
Danio rerio Vertebrates SYK SYK ncbigene_symbol syk 405769
Danio rerio Vertebrates CD22 CD22 ncbigene_symbol cd22 554810
Danio rerio Vertebrates HCLS1 HCLS1 ncbigene_symbol hcls1 563056
Danio rerio Vertebrates CBL CBL ncbigene_symbol cbl 492364
Danio rerio Vertebrates CBL CBL ncbigene_synonym cblb 556277
Danio rerio Vertebrates CD79B CD79B ncbigene_symbol cd79b 100329481
Danio rerio Vertebrates MAPK3 MAPK3 ncbigene_symbol mapk3 399480
Danio rerio Vertebrates PTPN18 PTPN18 ncbigene_symbol ptpn18 541324
Danio rerio Vertebrates RPS6KA1 RPS6KA1 ncbigene_symbol rps6ka1 777728
Danio rerio Vertebrates PLCG2 PLCG2 ncbigene_symbol plcg2 561747
Danio rerio Vertebrates BLNK BLNK ncbigene_symbol blnk 405764
Danio rerio Vertebrates PIK3AP1 PIK3AP1 ncbigene_symbol pik3ap1 100002256
Danio rerio Vertebrates SHC1 SHC1 ncbigene_symbol shc1 323818
Danio rerio Vertebrates CREB1 CREB1 ncbigene_synonym creb1a 573207
Danio rerio Vertebrates CDK4 CDK4 ncbigene_symbol cdk4 777730
Danio rerio Vertebrates CDK2 CDK2 ncbigene_symbol cdk2 406715
Danio rerio Vertebrates CDK6 CDK6 ncbigene_symbol cdk6 100034507
Danio rerio Vertebrates MAPK8 MAPK8 ncbigene_synonym mapk8b 65236
Danio rerio Vertebrates MAPK14 MAPK14 ncbigene_synonym mapk14a 65237
Danio rerio Vertebrates MAPK14 MAPK14 ncbigene_synonym mapk14b 266756
Danio rerio Vertebrates PIK3R2 PIK3R2 ncbigene_symbol pik3r2 404211
Danio rerio Vertebrates RB1 RB1 ncbigene_symbol rb1 777733
Danio rerio Vertebrates PPP3CA PPP3CA ncbigene_symbol ppp3ca 794574
Danio rerio Vertebrates PPP3R1 PPP3R1 ncbigene_synonym ppp3r1a 564337
Danio rerio Vertebrates AKT1 AKT1 ncbigene_symbol akt1 101910198
Danio rerio Vertebrates MAPK1 MAPK1 ncbigene_symbol mapk1 360144
Danio rerio Vertebrates RPS6KB1 RPS6KB1 ncbigene_synonym rps6kb1b 406349
Danio rerio Vertebrates NFATC1 NFATC1 ncbigene_symbol nfatc1 568315
Danio rerio Vertebrates NFATC3 NFATC3 ncbigene_synonym nfatc3a 561772
Danio rerio Vertebrates NFATC2 NFATC2 ncbigene_synonym nfatc2a 100333254
Danio rerio Vertebrates ELK1 ELK1 ncbigene_symbol elk1 567895
Danio rerio Vertebrates GSK3B GSK3B ncbigene_synonym gsk3ba 30654
Danio rerio Vertebrates RPS6 RPS6 ncbigene_symbol rps6 445028
Danio rerio Vertebrates BCL6 BCL6 ncbigene_synonym bcl6aa 393707
Danio rerio Vertebrates BRAF BRAF ncbigene_symbol braf 403065
Danio rerio Vertebrates BRAF BRAF ncbigene_synonym si:dkey-222f8.3 561722
Danio rerio Vertebrates GSK3A GSK3A ncbigene_synonym gsk3ab 30664

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA