Network of differentially expressed genes in the cell cycle control pathway in sorted R1/R2 Eklf−/− E13.5 fetal liver cells

Network of differentially expressed genes in the cell cycle control pathway in sorted R1/R2 Eklf−/− E13.5 fetal liver cells. IPA was performed on microarray data comparing R1 and R2 mRNA isolated from wild-type and Eklf−/− E13.5 fetal liver cells. Using 3,199 differentially expressed genes as the focus gene set, the highest-scoring pathway was cell cycle and DNA replication (score = 27; scores >3 indicate a significant chance that a biologically relevant network has been identified). Red nodes indicate upregulation in Eklf−/− cells; green nodes indicate downregulation in Eklf−/− cells. Arrows and lines denote interactions between specific genes within the network. A, activation; E, expression regulation; P, phosphorylation; PP, protein-protein interaction; PD, protein-DNA interaction; PR, protein-RNA interaction; RB, regulation of binding; L, proteolysis.

Publication

Failure of Terminal Erythroid Differentiation in EKLF-Deficient Mice Is Associated with Cell Cycle Perturbation and Reduced Expression of E2F2 . (2008) Andre M. Pilon, et al. Mol Cell Biol. 2008 Dec;28(24):7394-7401. Figure: F3. All organisms Mus musculus Homo sapiens Danio rerio

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