Proposed mechanism of the HOG pathway in fungal pathogens

Proposed mechanism of the HOG pathway in fungal pathogens. The upper panel describes the C. albicans HOG pathway, and the lower panel illustrates the C. neoformans HOG pathway. In each panel, the left side shows unstressed conditions while the right side illustrates stressed conditions. temp., temperature; MG, methylglyoxal.
Proposed mechanism of the HOG pathway in fungal pathogens
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Publication

Master and Commander in Fungal Pathogens: the Two-Component System and the HOG Signaling Pathway . (2008) Yong-Sun Bahn. Eukaryot Cell. 2008 Dec;7(12):2017-2036. Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Saccharomyces cerevisiae S288C Plants and Fungi Nik1 NIK1 ncbigene_synonym HSL1 853760
Saccharomyces cerevisiae S288C Plants and Fungi Sin1 SIN1 ncbigene_synonym SPT2 856908
Saccharomyces cerevisiae S288C Plants and Fungi Chk1 CHK1 ncbigene_symbol CHK1 852577
Saccharomyces cerevisiae S288C Plants and Fungi Ypd1? YPD1 ncbigene_symbol YPD1 851363
Saccharomyces cerevisiae S288C Plants and Fungi Ssk1 SSK1 ncbigene_symbol SSK1 850692
Saccharomyces cerevisiae S288C Plants and Fungi Ssk2 SSK2 ncbigene_symbol SSK2 855765
Saccharomyces cerevisiae S288C Plants and Fungi Hog1 HOG1 ncbigene_symbol HOG1 850803
Saccharomyces cerevisiae S288C Plants and Fungi Skn7 SKN7 ncbigene_symbol SKN7 856613
Saccharomyces cerevisiae S288C Plants and Fungi Pbs2 PBS2 ncbigene_symbol PBS2 853313
Homo sapiens Primates temp. TEMP ncbigene_synonym C1orf210 149466
Homo sapiens Primates Sin1 SIN1 ncbigene_synonym MAPKAP1 79109
Homo sapiens Primates Chk1 CHK1 ncbigene_synonym CHEK1 1111
Homo sapiens Primates Ssk1 SSK1 ncbigene_synonym BUB1B 701
Homo sapiens Primates PP2C,PTP? PTP ncbigene_synonym SLC25A3 5250
Homo sapiens Primates PP2C,PTP? PTP ncbigene_synonym REG1A 5967
Homo sapiens Primates PP2C,PTP? PTP ncbigene_synonym PTPRU 10076

Chemical mentions

Word Match MeSH Name ChEBI
Fludioxonil fludioxonil mesh:C108339 fludioxonil chebi:81763
Pheromone Pheromones mesh:D010675 pheromone chebi:26013

Disease mentions

Word Match MeSH Name DOID