Prostaglandin synthesis pathway
Prostaglandin synthesis pathway. A: cyclooxygenase is a heme-containing glycoprotein and is a key enzyme in prostanoid biosynthesis by catalyzing the conversion of arachidonic acid to PGH2. Subsequently, PGH2 is converted to active prostanoids via secondary prostanoid synthases. Prostacyclin has a half-life of ∼1 h before inactivation via a nonenzymatic hydration to form 6-keto-PGF1α. B: 6-keto-PGF1α is further metabolized in urine to form the 2,3-dinor derivative 2,3-dinor-6-keto-PGF1α.
Publication
Role of cyclooxygenase isoforms in prostacyclin biosynthesis and murine prehepatic portal hypertension. (2008) N. J. Skill, et al. Am J Physiol Gastrointest Liver Physiol. 2008 Nov;295(5):G953-G964. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | COX) | COX | ncbigene_synonym | COX8A | 1351 |
| Homo sapiens | Primates | COX) | COX | ncbigene_synonym | CPOX | 1371 |
| Homo sapiens | Primates | COX) | COX | ncbigene_synonym | COX5A | 9377 |
| Homo sapiens | Primates | COX) | COX | famplex_relations | COX5B | 1329 |
| Homo sapiens | Primates | COX) | COX | famplex_relations | COX6C | 1345 |
| Homo sapiens | Primates | COX) | COX | famplex_relations | COX7C | 1350 |
| Homo sapiens | Primates | COX) | COX | famplex_relations | NA | NaN |
| Homo sapiens | Primates | COX) | COX | famplex_relations | COX4I1 | 1327 |
| Homo sapiens | Primates | COX) | COX | famplex_relations | COX4I2 | 84701 |
| Homo sapiens | Primates | COX) | COX | famplex_relations | COX6A1 | 1337 |
| Homo sapiens | Primates | COX) | COX | famplex_relations | COX6A2 | 1339 |
| Homo sapiens | Primates | COX) | COX | famplex_relations | COX6B1 | 1340 |
| Homo sapiens | Primates | COX) | COX | famplex_relations | COX6B2 | 125965 |
| Homo sapiens | Primates | COX) | COX | famplex_relations | COX7A1 | 1346 |
| Homo sapiens | Primates | COX) | COX | famplex_relations | COX7A2 | 1347 |
| Homo sapiens | Primates | COX) | COX | famplex_relations | COX7B | 1349 |
| Homo sapiens | Primates | COX) | COX | famplex_relations | COX7B2 | 170712 |
| Homo sapiens | Primates | COX) | COX | famplex_relations | COX8C | 341947 |
| Homo sapiens | Primates | PGD2 | PGD2 | ncbigene_synonym | PTGDS | 5730 |
| Homo sapiens | Primates | PGD2 | PGD2 | ncbigene_synonym | HPGDS | 27306 |
| Homo sapiens | Primates | PGI, | PGI | ncbigene_synonym | BGN | 633 |
| Homo sapiens | Primates | PGI, | PGI | ncbigene_synonym | GPI | 2821 |
| Homo sapiens | Primates | PGI, | PGI | ncbigene_synonym | PGPEP1 | 54858 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| PGG2 | prostaglandin G2 | mesh:C038291 | prostaglandin G2 | chebi:27647 |
| Arachidonic acid | NA | mesh:D001095 | ||
| Prostaglandin Endoperoxyde | prostaglandin | mesh:D011453 | Prostaglandins | chebi:26333 |
| Prostacyclin | Epoprostenol | mesh:D011464 | prostaglandin I2 | chebi:15552 |
| Thromboxane | Thromboxanes | mesh:D013931 | thromboxane | chebi:26995 |
| PGE2 | Dinoprostone | mesh:D015232 | prostaglandin E2 | chebi:15551 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|