Insulin-like growth factor-I signaling pathway involved in breast cancer

Overview of the insulin-like growth factor-I signaling pathway involved in breast cancer. Insulin-like growth factor I (IGF-I) activates both the Ras/mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/serine–threonine kinase (AKT) pathways, and causes cell growth and proliferation. ERK1/2, extracellular signal-regulated kinase 1/2; GSK, glycogen synthase kinase; IGF-IR, insulin-like growth factor-I receptor; IRS-1, insulin receptor substrate; MEK1/2, mitogen-activated protein/extracellular signal-regulated kinase kinase; mTOR, mammalian target of rapamycin; PTEN, phosphatase and tensin homologue; Shc, GRB2, SOS1, adaptor proteins.
Insulin-like growth factor-I signaling pathway involved in breast cancer
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Publication

Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer. (2008) Mustafa Akkiprik, et al. Breast Cancer Res. 2008;10(4):212-212. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates IGF-1 IGF1 ncbigene_symbol IGF1 3479
Homo sapiens Primates IGF-IR IGFIR ncbigene_synonym IGF1R 3480
Homo sapiens Primates IRS-1 IRS1 ncbigene_symbol IRS1 3667
Homo sapiens Primates Shc SHC ncbigene_synonym SHC1 6464
Homo sapiens Primates Shc SHC famplex_relations SHC2 25759
Homo sapiens Primates Shc SHC famplex_relations SHC3 53358
Homo sapiens Primates Shc SHC famplex_relations SHC4 399694
Homo sapiens Primates sos1 SOS1 ncbigene_symbol SOS1 6654
Homo sapiens Primates GRB2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates PI3-K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3-K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3-K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3-K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3-K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3-K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3-K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3-K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3-K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3-K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates Raf RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates Raf RAF famplex_relations ARAF 369
Homo sapiens Primates Raf RAF famplex_relations BRAF 673
Homo sapiens Primates Raf RAF famplex_relations RAF1 5894
Homo sapiens Primates MEK1 MEK1 ncbigene_synonym MAP2K1 5604
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations ANGPT1 284
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations ANGPT2 285
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations ANGPT4 51378
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations AREG 374
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations BDNF 627
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations CSF1 1435
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations EFNA1 1942
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations EFNA2 1943
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations EFNA3 1944
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations EFNA4 1945
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations EFNA5 1946
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations EGF 1950
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations EREG 2069
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FGF1 2246
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FGF10 2255
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FGF16 8823
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FGF17 8822
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FGF18 8817
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FGF19 9965
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FGF2 2247
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FGF20 26281
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FGF21 26291
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FGF22 27006
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FGF23 8074
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FGF3 2248
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FGF4 2249
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FGF5 2250
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FGF6 2251
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FGF7 2252
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FGF8 2253
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FGF9 2254
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations FLT3LG 2323
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations HGF 3082
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations IGF2 3481
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations INS 3630
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations KITLG 4254
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations NGF 4803
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations NTF3 4908
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations NTF4 4909
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations PDGFA 5154
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations PDGFB 5155
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations PDGFC 56034
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations PDGFD 80310
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations PGF 5228
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations TGFA 7039
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations VEGFA 7422
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations VEGFB 7423
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations VEGFC 7424
Homo sapiens Primates Growthfactor, GROWTHFACTOR famplex_relations VEGFD 2277
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates Bad BAD ncbigene_symbol BAD 572
Homo sapiens Primates Bcl-2 BCL-2 ncbigene_synonym BCL2 596
Homo sapiens Primates GSK-3B GSK3B ncbigene_symbol GSK3B 2932
Homo sapiens Primates Bcl-x BCL-X ncbigene_synonym BCL2L1 598
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates c-fos C-FOS ncbigene_synonym FOS 2353
Homo sapiens Primates c-jun C-JUN ncbigene_synonym JUN 3725

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Cardiomyopathy NA
Lung cancer NA
Noonan syndrome NA