Signaling pathway for proceeding from FosB toward thrombospondin 1/TGFB1
Signaling pathway for proceeding from FosB or ΔFosB/Δ2ΔFosB toward thrombospondin 1/TGF-β1, which regulates cell-matrix adhesion. Thrombospondin 1/TGF-β1 signaling, which may be negatively regulated by Jun/Fos complexes (active AP-1), enhances cell-matrix adhesion and up-regulates genes for basement membrane proteins through fosB gene expression. ΔFosB and Δ2ΔFosB antagonize not only FosB but also other Fos family members (Fos) constituting the major AP-1 complexes with the three Jun proteins (Jun), and they may up-regulate the TGF-β1 signaling pathway independent of intrinsic AP-1 activity. See details in the text and Supplemental Figure S2. Red represents up-regulated genes and blue indicates down-regulated genes.
Publication
Antagonistic Regulation of Cell-Matrix Adhesion by FosB and ΔFosB/Δ2ΔFosB Encoded by Alternatively Spliced Forms of fosB Transcripts. (2008) Yoshinori N. Ohnishi, et al. Mol Biol Cell. 2008 Nov;19(11):4717-4729. Figure: F8.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | d/d | DD | ncbigene_symbol | Dd | 33107 |
| Drosophila melanogaster | Invertebrates | Null | NULL | ncbigene_synonym | Hr4 | 31162 |
| Drosophila melanogaster | Invertebrates | Null | NULL | ncbigene_synonym | PsGEF | 31224 |
| Drosophila melanogaster | Invertebrates | AP-1 | AP-1 | ncbigene_synonym | AP-1gamma | 31842 |
| Drosophila melanogaster | Invertebrates | AP-1 | AP-1 | ncbigene_synonym | Jra | 36057 |
| Drosophila melanogaster | Invertebrates | AP-1 | AP-1 | ncbigene_synonym | kay | 3772082 |
| Drosophila melanogaster | Invertebrates | an | AN | ncbigene_symbol | an | 247752 |
| Drosophila melanogaster | Invertebrates | Ju | JU | ncbigene_symbol | ju | 5657012 |
| Drosophila melanogaster | Invertebrates | Jan | JAN | ncbigene_synonym | janB | 43568 |
| Drosophila melanogaster | Invertebrates | Jan | JAN | ncbigene_synonym | janA | 43569 |
| Drosophila melanogaster | Invertebrates | Fes | FES | ncbigene_synonym | Rbp9 | 33498 |
| Drosophila melanogaster | Invertebrates | LIE.- | LIE | ncbigene_synonym | EcR | 35540 |
| Drosophila melanogaster | Invertebrates | un | UN | ncbigene_symbol | un | 45370 |
| Drosophila melanogaster | Invertebrates | Pos | POS | ncbigene_symbol | Pos | 43762 |
| Drosophila melanogaster | Invertebrates | las | LAS | ncbigene_symbol | Las | 40259 |
| Homo sapiens | Primates | AP-1 | AP-1 | ncbigene_synonym | FOS | 2353 |
| Homo sapiens | Primates | AP-1 | AP-1 | ncbigene_synonym | FOSB | 2354 |
| Homo sapiens | Primates | AP-1 | AP-1 | ncbigene_synonym | JUN | 3725 |
| Homo sapiens | Primates | AP-1 | AP-1 | ncbigene_synonym | JUNB | 3726 |
| Homo sapiens | Primates | AP-1 | AP-1 | ncbigene_synonym | JUND | 3727 |
| Homo sapiens | Primates | AP1 | AP1 | famplex_relations | FOSL1 | 8061 |
| Homo sapiens | Primates | AP1 | AP1 | famplex_relations | FOSL2 | 2355 |
| Homo sapiens | Primates | an | AN | ncbigene_symbol | AN | 100187761 |
| Homo sapiens | Primates | Fes | FES | ncbigene_symbol | FES | 2242 |
| Homo sapiens | Primates | Foe | FOE | ncbigene_synonym | WAPL | 23063 |
| Homo sapiens | Primates | las | LAS | ncbigene_synonym | LIAS | 11019 |
| Homo sapiens | Primates | TGF-B1 | TGF-B1 | ncbigene_synonym | TGFB1 | 7040 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|