Androgen synthesis pathway and therapeutic targets

Androgen synthesis pathway and therapeutic targets. Cholesterol is synthesized from Acetyl-CoA and enzymes in this pathway were found to be upregulated by Holzbeierlein et. al. (red) []. Subsequently, the weak androgen androstenedione, testosterone, and the potent DHT are synthesized from cholesterol and enzymes in this pathway were found to be upregulated by Stanbrough et. al. (blue) and Montgomery et. al. (orange) [,]. Abiraterone blocks CYP17 which contain both 17α-hydroxylase/C17,20-lyase activities (boxed orange). Dutasteride blocks both SRD5A1 and SRD5A2 (boxed green).
Androgen synthesis pathway and therapeutic targets
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Publication

Targeting the androgen receptor pathway in prostate cancer. () Yu Chen, et al. Curr Opin Pharmacol. ;8(4):440-448. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents HSD3B1 HSD3B1 ncbigene_symbol Hsd3b1 15492
Mus musculus Rodents HSD3B2 HSD3B2 ncbigene_symbol Hsd3b2 15493
Mus musculus Rodents HSD3B3 HSD3B3 ncbigene_symbol Hsd3b3 15494
Mus musculus Rodents SRD5A1 SRD5A1 ncbigene_symbol Srd5a1 78925
Mus musculus Rodents SRD5A2 SRD5A2 ncbigene_symbol Srd5a2 94224
Rattus norvegicus Rodents HSD3B1 HSD3B1 ncbigene_symbol Hsd3b1 360348
Rattus norvegicus Rodents HSD3B1 HSD3B1 ncbigene_synonym Hsd3b2 29632
Rattus norvegicus Rodents HSD3B3 HSD3B3 ncbigene_symbol Hsd3b3 682974
Rattus norvegicus Rodents SRD5A1 SRD5A1 ncbigene_symbol Srd5a1 24950
Rattus norvegicus Rodents SRD5A2 SRD5A2 ncbigene_symbol Srd5a2 64677
Homo sapiens Primates HSD3B1 HSD3B1 ncbigene_symbol HSD3B1 3283
Homo sapiens Primates HSD3B2 HSD3B2 ncbigene_symbol HSD3B2 3284
Homo sapiens Primates SRD5A1 SRD5A1 ncbigene_symbol SRD5A1 6715
Homo sapiens Primates SRD5A2 SRD5A2 ncbigene_symbol SRD5A2 6716
Ovis aries Mammals HSD3B1 HSD3B1 ncbigene_symbol HSD3B1 100190978
Ovis aries Mammals SRD5A1 SRD5A1 ncbigene_symbol SRD5A1 100642181
Ovis aries Mammals SRD5A2 SRD5A2 ncbigene_symbol SRD5A2 100820756

Chemical mentions

Word Match MeSH Name ChEBI
Squalene-2,3 Epoxide NA mesh:C002821
Farnesyl pyrophosphate 2-trans,6-trans-farnesyl diphosphate mesh:C004808 farnesyl pyrophosphate chebi:17407
Aldosterone Aldosterone mesh:D000450 aldosterone chebi:27584
Androstenedione Androstenedione mesh:D000735 androst-4-ene-3,17-dione chebi:16422
Cholesterol Cholesterol mesh:D002784 cholesterol chebi:16113
DHEA Dehydroepiandrosterone mesh:D003687 dehydroepiandrosterone chebi:28689
Cortisol Hydrocortisone mesh:D006854 cortisol chebi:17650
Lanosterol Lanosterol mesh:D007810 lanosterol chebi:16521
17a-OH Pregnenolone Pregnenolone mesh:D011284 pregnenolone chebi:16581
Pregnenolone Pregnenolone mesh:D011284 pregnenolone chebi:16581
17a-OH Progesterone Progesterone mesh:D011374 progesterone chebi:17026
Progesterone Progesterone mesh:D011374 progesterone chebi:17026
Squalene Squalene mesh:D013185 squalene chebi:15440
Testosterone Testosterone mesh:D013739 testosterone chebi:17347

Disease mentions

Word Match MeSH Name DOID