The Shh signaling pathway

The Shh signaling pathway. In the absence of Sonic hedgehog (Shh), Patched 1 (Ptc1) represses the activation of Smoothened (Smo) and the downstream transduction cascade (Inactivation). Binding of Shh to the Ptc 1 activates Smo and this complex regulates Gli activity in nucleus.
The Shh signaling pathway
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Publication

Ischemic stroke and Neurogenesis in the Subventricular Zone. () Rui Lan Zhang, et al. Neuropharmacology. ;55(3):345-352. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates PTC PTC ncbigene_symbol ptc 35851
Drosophila melanogaster Invertebrates Smo SMO ncbigene_symbol smo 33196
Drosophila melanogaster Invertebrates Smo SMO ncbigene_synonym sm 37254
Drosophila melanogaster Invertebrates Sme SME ncbigene_symbol SmE 34080
Drosophila melanogaster Invertebrates Gli GLI ncbigene_symbol Gli 34927
Drosophila melanogaster Invertebrates Gli GLI ncbigene_synonym ci 43767
Homo sapiens Primates Shh SHH ncbigene_symbol SHH 6469
Homo sapiens Primates PTC PTC ncbigene_synonym F9 2158
Homo sapiens Primates PTC PTC ncbigene_synonym TAS2R38 5726
Homo sapiens Primates PTC PTC ncbigene_synonym PTCH1 5727
Homo sapiens Primates PTC PTC ncbigene_synonym RET 5979
Homo sapiens Primates PTC PTC ncbigene_synonym CCDC6 8030
Homo sapiens Primates Smo SMO ncbigene_symbol SMO 6608
Homo sapiens Primates Smo SMO ncbigene_synonym SMOX 54498
Homo sapiens Primates Sme SME ncbigene_synonym SNRPE 6635
Homo sapiens Primates Gli GLI ncbigene_synonym GLI1 2735

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID