Signaling Flux Redistribution at Toll-Like Receptor Pathway Junctions

(A) removal of MyD88 results in enhancement of TRAM-dependant pathway, (B) removal of TRAF6 results in enhancement of TRAM-dependant pathway downstream of TRIF, (C) overexpression of MyD88 downregulates TRAM-dependant pathway, (D) removal of TRAM does not enhance the MyD88-dependant pathway due to upstream intermediates. * signaling molecules/events upstream of TRAM , , .
Signaling Flux Redistribution at Toll-Like Receptor Pathway Junctions
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Publication

Signaling Flux Redistribution at Toll-Like Receptor Pathway Junctions. (2008) Kumar Selvarajoo, et al. PLoS One. 2008;3(10):e3430. Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates MYD88, MYD88 ncbigene_symbol MYD88 4615
Homo sapiens Primates TRAM TRAM ncbigene_synonym TRAM1 23471
Homo sapiens Primates TRAM TRAM ncbigene_synonym TICAM2 353376
Homo sapiens Primates TRAM TRAM ncbigene_synonym TMED7-TICAM2 100302736
Homo sapiens Primates TRIF TRIF ncbigene_synonym TRIM69 140691
Homo sapiens Primates TRIF TRIF ncbigene_synonym TICAM1 148022
Homo sapiens Primates TBK1 TBK1 ncbigene_symbol TBK1 29110
Homo sapiens Primates TRAF6 TRAF6 ncbigene_symbol TRAF6 7189
Danio rerio Vertebrates MYD88, MYD88 ncbigene_symbol myd88 403145
Danio rerio Vertebrates TRAM TRAM ncbigene_synonym tram1 266757
Danio rerio Vertebrates TRIF TRIF ncbigene_synonym ticam1 403147
Danio rerio Vertebrates TBK1 TBK1 ncbigene_symbol tbk1 692289
Danio rerio Vertebrates TRAF6 TRAF6 ncbigene_symbol traf6 554561
Drosophila melanogaster Invertebrates MYD88, MYD88 ncbigene_symbol Myd88 35956
Drosophila melanogaster Invertebrates TRAM TRAM ncbigene_symbol TRAM 31042
Drosophila melanogaster Invertebrates TRAF6 TRAF6 ncbigene_symbol Traf6 31746
Drosophila melanogaster Invertebrates D88 D88 ncbigene_synonym chic 33834

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID