NFKB canonical signaling pathway from IPA

The NFκB canonical signaling pathway from IPA. Dark red > 3-fold increase in gene expression; light red < 3-fold increase in gene expression; dark green – > 3-fold decrease in gene expression; light green – < 3-fold decrease in gene expression; gray – unchanged gene expression; no color – gene not in array. Gene symbols with a single border represent single genes. Double border represent a complex of genes or the possibility that alternative genes might act in the pathway.
NFKB canonical signaling pathway from IPA
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Publication

From microarray to biology: an integrated experimental, statistical and in silico analysis of how the extracellular matrix modulates the phenotype of cancer cells. (2008) Mikhail G Dozmorov, et al. BMC Bioinformatics. 2008;9(Suppl 9):S4-S4. Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates RANKL RANKL ncbigene_synonym TNFSF11 8600
Homo sapiens Primates EGF EGF ncbigene_symbol EGF 1950
Homo sapiens Primates IL-1 IL-1 ncbigene_synonym IL1B 3553
Homo sapiens Primates BAFF BAFF ncbigene_synonym TNFSF13B 10673
Homo sapiens Primates NGF NGF ncbigene_symbol NGF 4803
Homo sapiens Primates TGF-a TGFA ncbigene_symbol TGFA 7039
Homo sapiens Primates CD40L CD40L ncbigene_synonym CD40LG 959
Homo sapiens Primates LTA LTA ncbigene_symbol LTA 4049
Homo sapiens Primates TIRAP TIRAP ncbigene_symbol TIRAP 114609
Homo sapiens Primates TRAF2 TRAF2 ncbigene_symbol TRAF2 7186
Homo sapiens Primates TRAF2 TRAF2 ncbigene_synonym TANK 10010
Homo sapiens Primates TRAF TRAF famplex_relations TRAF1 7185
Homo sapiens Primates TRAF TRAF famplex_relations TRAF3 7187
Homo sapiens Primates TRAF TRAF famplex_relations TRAF4 9618
Homo sapiens Primates TRAF TRAF famplex_relations TRAF5 7188
Homo sapiens Primates TRAF TRAF famplex_relations TRAF6 7189
Homo sapiens Primates TRAF TRAF famplex_relations TRAF7 84231
Homo sapiens Primates LCK LCK ncbigene_symbol LCK 3932
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates RIP RIP ncbigene_synonym AGFG1 3267
Homo sapiens Primates RIP RIP ncbigene_synonym RIPK1 8737
Homo sapiens Primates RIP RIP ncbigene_synonym DCAF1 9730
Homo sapiens Primates RIP RIP ncbigene_synonym RPAIN 84268
Homo sapiens Primates Zap70 ZAP70 ncbigene_symbol ZAP70 7535
Homo sapiens Primates A20 A20 ncbigene_synonym TNFAIP3 7128
Homo sapiens Primates A20 A20 ncbigene_synonym IGKV1-27 28935
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates PLCY2 PLCG2 ncbigene_symbol PLCG2 5336
Homo sapiens Primates NIK NIK ncbigene_synonym MAP3K14 9020
Homo sapiens Primates NIK NIK ncbigene_synonym MAP4K4 9448
Homo sapiens Primates IKKA IKKA ncbigene_synonym CHUK 1147
Homo sapiens Primates IKKY IKKG ncbigene_synonym IKBKG 8517
Homo sapiens Primates NF-KB1 NF-KB1 ncbigene_synonym NFKB1 4790
Homo sapiens Primates p50 P50 ncbigene_synonym CD40 958
Homo sapiens Primates p50 P50 ncbigene_synonym ARHGEF7 8874
Homo sapiens Primates p50 P50 ncbigene_synonym ASCC1 51008
Homo sapiens Primates p50 P50 ncbigene_synonym H3P40 115482723
Homo sapiens Primates RelA RELA ncbigene_symbol RELA 5970
Homo sapiens Primates p65 P65 ncbigene_synonym SYT1 6857
Homo sapiens Primates p65 P65 ncbigene_synonym GORASP1 64689
Homo sapiens Primates p65 P65 ncbigene_synonym WNK1 65125
Homo sapiens Primates acts ACT ncbigene_synonym SERPINA3 12
Homo sapiens Primates acts ACT ncbigene_synonym ACTG1 71
Homo sapiens Primates acts ACT ncbigene_synonym ACTG2 72
Homo sapiens Primates acts ACT ncbigene_synonym FHL5 9457
Homo sapiens Primates acts ACT ncbigene_synonym ACOT7 11332
Homo sapiens Primates acts ACT ncbigene_synonym ACTBL2 345651
Homo sapiens Primates acts ACT ncbigene_synonym POTEKP 440915
Homo sapiens Primates acts ACT ncbigene_synonym POTEM 641455
Homo sapiens Primates hb HB ncbigene_synonym GSTM1 2944
Homo sapiens Primates ert ERT ncbigene_synonym ELF3 1999
Homo sapiens Primates RelB RELB ncbigene_symbol RELB 5971
Homo sapiens Primates NFKB NFKB famplex_relations REL 5966
Homo sapiens Primates NFKB NFKB famplex_relations NFKB2 4791
Danio rerio Vertebrates BMP24 BMP24 ncbigene_synonym bmp2b 30632
Danio rerio Vertebrates EGF EGF ncbigene_symbol egf 403045
Danio rerio Vertebrates EGF EGF ncbigene_synonym celsr1a 368436
Danio rerio Vertebrates NGF NGF ncbigene_synonym ngfb 58133
Danio rerio Vertebrates TGF-a TGFA ncbigene_symbol tgfa 100034402
Danio rerio Vertebrates LTA LTA ncbigene_symbol lta 554305
Danio rerio Vertebrates TIRAP TIRAP ncbigene_symbol tirap 403148
Danio rerio Vertebrates LCK LCK ncbigene_symbol lck 414333
Danio rerio Vertebrates Ras RAS ncbigene_synonym rab1ab 368883
Danio rerio Vertebrates Zap70 ZAP70 ncbigene_symbol zap70 553615
Danio rerio Vertebrates PLCY2 PLCG2 ncbigene_symbol plcg2 561747
Danio rerio Vertebrates NF-KB1 NFKB1 ncbigene_symbol nfkb1 565756
Danio rerio Vertebrates RelA RELA ncbigene_symbol rela 415099
Danio rerio Vertebrates RelB RELB ncbigene_symbol relb 795414
Danio rerio Vertebrates HDAC12 HDAC12 ncbigene_symbol hdac12 100148903

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA