Time ordered sequential events control cellular decision of migration

Time ordered sequential events control cellular decision of migration. Schematic representation of events regulating the initiation, maintenance, modulation and stopping of cell migration. (A) The migratory response depends on a certain threshold of gene activity, as indicated by the dashed line, and proceeds as long as no context information is provided via a stop signal or the sustained activation is depleted. (B) Summary scheme of the model for migration. A first pulse-like HGF stimulus is required to transform the cell into a sensitive state for migration. To initiate and sustain migration, a second input preferably through the EGF-R signaling pathway is required. This second input can be modulated by a number of genes. Context information is integrated through the PKA pathway, which can stop migration at any point in time.
Time ordered sequential events control cellular decision of migration
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Publication

Gene network dynamics controlling keratinocyte migration. (2008) Hauke Busch, et al. Mol Syst Biol. 2008;4:199-199. Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Bos taurus Mammals cll CL1 ncbigene_synonym TMEM176A 404082
Bos taurus Mammals Errfi1, ERRFI1 ncbigene_symbol ERRFI1 516303
Bos taurus Mammals Dhrs9 DHRS9 ncbigene_symbol DHRS9 282851
Bos taurus Mammals HGF HGF ncbigene_symbol HGF 282879
Bos taurus Mammals (PLAU- PLAU ncbigene_symbol PLAU 281408
Bos taurus Mammals EGFR EGFR ncbigene_symbol EGFR 407217
Bos taurus Mammals (AKAP-12 AKAP12 ncbigene_symbol AKAP12 513774
Bos taurus Mammals EGR-1 EGR1 ncbigene_symbol EGR1 407125
Bos taurus Mammals EGR-3 EGR3 ncbigene_symbol EGR3 526233
Bos taurus Mammals PTGS-2 PTGS2 ncbigene_symbol PTGS2 282023
Bos taurus Mammals Fos FOS ncbigene_symbol FOS 280795
Homo sapiens Primates cll CL1 ncbigene_synonym DCLK1 9201
Homo sapiens Primates cll CL1 ncbigene_synonym ADGRL1 22859
Homo sapiens Primates cll CLI ncbigene_synonym CLU 1191
Homo sapiens Primates cll C11 ncbigene_synonym AKR1C4 1109
Homo sapiens Primates cll C11 ncbigene_synonym GZMB 3002
Homo sapiens Primates cll C11 ncbigene_synonym POLR3K 51728
Homo sapiens Primates ErbB ERBB ncbigene_synonym EGFR 1956
Homo sapiens Primates ErbB ERBB famplex_relations ERBB2 2064
Homo sapiens Primates ErbB ERBB famplex_relations ERBB3 2065
Homo sapiens Primates ErbB ERBB famplex_relations ERBB4 2066
Homo sapiens Primates PKA PKA famplex_relations PRKAR1A 5573
Homo sapiens Primates PKA PKA famplex_relations PRKAR1B 5575
Homo sapiens Primates PKA PKA famplex_relations PRKAR2A 5576
Homo sapiens Primates PKA PKA famplex_relations PRKAR2B 5577
Homo sapiens Primates PKA PKA famplex_relations PRKACA 5566
Homo sapiens Primates PKA PKA famplex_relations PRKACB 5567
Homo sapiens Primates PKA PKA famplex_relations PRKACG 5568
Homo sapiens Primates via VIA ncbigene_synonym SEMA6A 57556
Homo sapiens Primates Errfi1, ERRFI1 ncbigene_symbol ERRFI1 54206
Homo sapiens Primates Dhrs9 DHRS9 ncbigene_symbol DHRS9 10170
Homo sapiens Primates HGF HGF ncbigene_symbol HGF 3082
Homo sapiens Primates HGF HGF ncbigene_synonym IL6 3569
Homo sapiens Primates HGF HGF ncbigene_synonym SOS1 6654
Homo sapiens Primates (PLAU- PLAU ncbigene_symbol PLAU 5328
Homo sapiens Primates (AKAP-12 AKAP12 ncbigene_symbol AKAP12 9590
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates stop STOP ncbigene_synonym MAP6 4135
Homo sapiens Primates EGR-1 EGR1 ncbigene_symbol EGR1 1958
Homo sapiens Primates EGR-3 EGR-3 ncbigene_synonym EGR3 1960
Homo sapiens Primates PTGS-2 PTGS2 ncbigene_symbol PTGS2 5743
Homo sapiens Primates Fos FOS ncbigene_symbol FOS 2353
Homo sapiens Primates Fos FOS famplex_relations FOSB 2354
Homo sapiens Primates Fos FOS famplex_relations FOSL1 8061
Homo sapiens Primates Fos FOS famplex_relations FOSL2 2355
Mus musculus Rodents cll CLI ncbigene_synonym Clu 12759
Mus musculus Rodents cll C11 ncbigene_synonym Polr3k 67005
Mus musculus Rodents cll C11 ncbigene_synonym Pip4k2b 108083
Mus musculus Rodents ErbB ERBB ncbigene_synonym Egfr 13649
Mus musculus Rodents via VIA ncbigene_synonym Sema6a 20358
Mus musculus Rodents Errfi1, ERRFI1 ncbigene_symbol Errfi1 74155
Mus musculus Rodents Dhrs9 DHRS9 ncbigene_symbol Dhrs9 241452
Mus musculus Rodents HGF HGF ncbigene_symbol Hgf 15234
Mus musculus Rodents HGF HGF ncbigene_synonym Met 17295
Mus musculus Rodents (PLAU- PLAU ncbigene_symbol Plau 18792
Mus musculus Rodents (AKAP-12 AKAP12 ncbigene_symbol Akap12 83397
Mus musculus Rodents stop STOP ncbigene_synonym Map6 17760
Mus musculus Rodents EGR-1 EGR-1 ncbigene_synonym Egr1 13653
Mus musculus Rodents EGR-3 EGR-3 ncbigene_synonym Egr3 13655
Mus musculus Rodents PTGS-2 PTGS2 ncbigene_symbol Ptgs2 19225
Mus musculus Rodents Fos FOS ncbigene_symbol Fos 14281
Drosophila melanogaster Invertebrates cll CLL ncbigene_synonym C15 42544
Drosophila melanogaster Invertebrates cll CLI ncbigene_symbol Cli 5657022
Drosophila melanogaster Invertebrates cll CLI ncbigene_synonym eya 33916
Drosophila melanogaster Invertebrates and AND ncbigene_synonym CkIIbeta 32132
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Andorra 32798
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Anp 43595
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Acam 44913
Drosophila melanogaster Invertebrates PKA PKA ncbigene_synonym Pka-C1 34284
Drosophila melanogaster Invertebrates PKA PKA ncbigene_synonym Pka-R2 36041
Drosophila melanogaster Invertebrates PKA PKA ncbigene_synonym Pka-C3 39733
Drosophila melanogaster Invertebrates PKA PKA ncbigene_synonym Pka-R1 40305
Drosophila melanogaster Invertebrates PKA PKA ncbigene_synonym Pka-C2 43644
Drosophila melanogaster Invertebrates via VIA ncbigene_synonym levy 37728
Drosophila melanogaster Invertebrates via VIA ncbigene_synonym COX6AL2 40066
Drosophila melanogaster Invertebrates off OFF ncbigene_symbol Off 249997
Drosophila melanogaster Invertebrates EGFR EGFR ncbigene_symbol Egfr 37455
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym MKP-4 32963
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym p38b 34780
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates Start,maintain, START ncbigene_synonym Start1 37927
Drosophila melanogaster Invertebrates stop STOP ncbigene_symbol stop 252732
Drosophila melanogaster Invertebrates Fos FOS ncbigene_synonym kay 3772082

Chemical mentions

Word Match MeSH Name ChEBI
DHAS dehydroacetic acid mesh:C027493 dehydroacetic acid chebi:137426
Met NA mesh:D008715

Disease mentions

Word Match MeSH Name DOID