Representation of the two NFKB signaling pathways

Representation of the two NF-κB signaling pathways. Classical signaling (depicted left) is activated by TNFα, IL1β or LPS. Activation of canonical signaling depends on the IKK holocomplex (IKKα, IKKβ, IKKγ/NEMO). Activated IKK phosphorylates IκBs, leading to the proteasomal degradation and subsequent nuclear translocation of classical NF-κB. An alternative signaling pathway (depicted right) is activated by lymphotoxin, CD40L or BAFF. Signaling depends on IKKα and leads to the nuclear translocation of a p52/RelB dimer.
Representation of the two NFKB signaling pathways
Download JPG
View figure at PMC Read paper at PMC Open at NDEx
PMC
NDEx

Publication

Apoptotic pathways in pancreatic ductal adenocarcinoma. (2008) Rainer Hamacher, et al. Mol Cancer. 2008;7:64-64. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates LPS, LPS ncbigene_synonym IRF6 3664
Homo sapiens Primates IL1) IL1 ncbigene_synonym IL1A 3552
Homo sapiens Primates IL1) IL1 ncbigene_synonym IL1B 3553
Homo sapiens Primates (TNFa, TNFA ncbigene_synonym TNF 7124
Homo sapiens Primates CD40) CD40 ncbigene_symbol CD40 958
Homo sapiens Primates (LTB,BAFF,CD40) BAFF ncbigene_synonym TNFSF13B 10673
Homo sapiens Primates (LTB, LTB ncbigene_symbol LTB 4050
Homo sapiens Primates NIK NIK ncbigene_synonym MAP3K14 9020
Homo sapiens Primates NIK NIK ncbigene_synonym MAP4K4 9448
Homo sapiens Primates (NEMO) NEMO ncbigene_synonym IKBKG 8517
Homo sapiens Primates IKKB IKKB ncbigene_synonym IKBKB 3551
Homo sapiens Primates IKK« IKK famplex_relations CHUK 1147
Homo sapiens Primates IKK« IKK famplex_relations IKBKE 9641
Homo sapiens Primates IKK« IKK famplex_relations TBK1 29110
Homo sapiens Primates p100 P100 ncbigene_synonym CUX1 1523
Homo sapiens Primates p100 P100 ncbigene_synonym NFKB2 4791
Homo sapiens Primates p100 P100 ncbigene_synonym OAS3 4940
Homo sapiens Primates p100 P100 ncbigene_synonym PMEL 6490
Homo sapiens Primates p100 P100 ncbigene_synonym SART3 9733
Homo sapiens Primates p100 P100 ncbigene_synonym TPX2 22974
Homo sapiens Primates p100 P100 ncbigene_synonym SND1 27044
Homo sapiens Primates p100 P100 ncbigene_synonym ASCC2 84164
Homo sapiens Primates IKBa IKBA ncbigene_synonym NFKBIA 4792
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMA1 5682
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMA2 5683
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMA3 5684
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMA4 5685
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMA5 5686
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMA6 5687
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMA7 5688
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMA8 143471
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB1 5689
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB10 5699
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB2 5690
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB3 5691
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB4 5692
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB5 5693
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB6 5694
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB7 5695
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB8 5696
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB9 5698
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMC1 5700
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMC2 5701
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMC3 5702
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMC4 5704
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMC5 5705
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMC6 5706
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD1 5707
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD10 5716
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD11 5717
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD12 5718
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD13 5719
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD14 10213
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD2 5708
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD3 5709
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD4 5710
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD5 5711
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD6 9861
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD7 5713
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD8 5714
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD9 5715
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSME1 5720
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSME2 5721
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSME3 10197
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMF1 9491
Homo sapiens Primates proteasome PROTEASOME famplex_relations SEM1 7979
Homo sapiens Primates proteasome PROTEASOME famplex_relations USP5 8078
Homo sapiens Primates RelB RELB ncbigene_symbol RELB 5971
Homo sapiens Primates RelA RELA ncbigene_symbol RELA 5970
Homo sapiens Primates p50 P50 ncbigene_synonym ARHGEF7 8874
Homo sapiens Primates p50 P50 ncbigene_synonym ASCC1 51008
Homo sapiens Primates p50 P50 ncbigene_synonym H3P40 115482723
Homo sapiens Primates p52 P52 ncbigene_synonym FKBP4 2288
Homo sapiens Primates p52 P52 ncbigene_synonym GTF2H4 2968
Homo sapiens Primates p52 P52 ncbigene_synonym PMPCB 9512
Homo sapiens Primates p52 P52 ncbigene_synonym PSIP1 11168
Homo sapiens Primates p52 P52 ncbigene_synonym H3P42 115482704
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Danio rerio Vertebrates (TNFa,LPS,IL1) TNFA ncbigene_symbol tnfa 405785
Danio rerio Vertebrates (TNFa,LPS,IL1) TNFA ncbigene_synonym tnfb 554167
Danio rerio Vertebrates CD40) CD40 ncbigene_symbol cd40 100270764
Danio rerio Vertebrates (NEMO) NEMO ncbigene_synonym ikbkg 541530
Danio rerio Vertebrates p100 P100 ncbigene_synonym nfkb2 415100
Danio rerio Vertebrates RelB RELB ncbigene_symbol relb 795414
Danio rerio Vertebrates RelA RELA ncbigene_symbol rela 415099
Danio rerio Vertebrates p50 P50 ncbigene_synonym nfkb1 565756

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID